Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN988042
Suzuki, McCall, Choi, Sicklick, Huang, Qi, Zdanowicz, Camp, Li, Diehl: Interleukin-15 increases hepatic regenerative activity. in Journal of hepatology 2006
Show all 4 Pubmed References
T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (zeige CD3 Proteine)(-) CD8 (zeige CD8A Proteine)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (zeige IFNG Proteine), and that IL-15 elicits IFN-gamma (zeige IFNG Proteine) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (zeige CD8A Proteine) antigen, IFN-gamma (zeige IFNG Proteine)]
Our new compelling findings have established the critical roles of both IL-7 (zeige IL7 Proteine) and IL-15 in the maintenance of memory Th17 cells, and the previously undescribed therapeutic advantages of targeting IL-7 (zeige IL7 Proteine) and IL-15 further support a promising clinical translation in Th17 cell-mediated autoimmune and inflammatory disorders.
results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease
homeostasis of IL-15-dependent lymphocyte subsets is also regulated by trans-presentation of IL-15 by non-hematopoietic cells in the tissue environment.
Recombinant IL-15 is a promising agent for cancer immunotherapy both in humans and animals.
Taken together, these data suggest that CCR7 (zeige CCR7 Proteine) biases memory CD8 (zeige CD8A Proteine) T cells toward IL-7 (zeige IL7 Proteine)-dependent niches over IL-15-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets.
results demonstrate that IL-15 and RANKL (zeige TNFSF11 Proteine) induce osteoclastogenesis synergistically, and IL-15 might play a novel and major role in destructive inflammatory bone diseases
This study provides mechanistic insight into how IL-15 controls the generation of memory CD8 (zeige CD8A Proteine) T cells and influences their trafficking and ability to take up residence within peripheral tissues.
findings extend understanding of the differential modes of action between IL-2 (zeige IL2 Proteine) and IL-15, and highlight how, although sharing the CD122 (zeige IL2RB Proteine)/CD132 (zeige IL2RG Proteine) receptor, they elicit such different immune actions
IL-15 induced by inflammatory signals in response to lymphodepletion drives lymphocyte responses, as memory CD8 (zeige CD8A Proteine) T cells proliferated in an IL-15-dependent manner.
these findings unveil a role for IL-15 as a critical mediator in defense against systemic candidiasis and hold promise for the design of IL-15-based antifungal immunotherapies.
the critical role played by IL-7 and IL-15 in T cell homeostasis and how these cytokines could be used to improve immune reconstitution after allogeneic SCT.
Downregulation of Hsc70 (zeige HSPA8 Proteine), Hsp70 (zeige HSP70 Proteine), and IL-15 expression at gene and/or protein levels might support the retention of fertilization products in cases of missed abortion and blighted ovum.
The presence of IL15 rs10833 AA genotype in HIV-/HCV-co-infected patients was associated with advanced liver fibrosis, inflammation-related biomarkers and increased rates of sustained virological response to pegIFN-alpha/RBV therapy.
High IL15 expression is associated with endometriosis.
IL-15 drives bystander activation of CD8 (zeige CD8A Proteine)+ T cells, which predicts disease progression in untreated HIV-1-infected patients and suggests that elevated IL-15 may also drive CD8 (zeige CD8A Proteine)+ T cell expansion that is linked to increased morbidity and mortality in treated patients
Sustained virologic response was significantly associated with IL15 rs10833 in chronic hepatitis C patients, treated with pegylated interferon-alpha (zeige IFNA Proteine) and ribavirin.
IL-15 mRNA and protein levels significantly increased in rhHBcAg stimulation group compared with non-stimulated group.
this work provides evidence that the sushi-IL-15Ralpha/IL-15 fusion protein RLI (zeige ABCE1 Proteine) enhances antitumor activity of anti-PD-1 (zeige PDCD1 Proteine) treatment and is a promising approach to stimulate host immunity
These results reveal a novel role of IL-7 (zeige IL7 Proteine) and IL-15 in maintaining human T cell function, provide an explanation for T cell dysfunction in humanized mice, and have significant implications for in vitro studies with human T cells.
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (zeige FYN Proteine) and NF-kappaB (zeige NFKB1 Proteine) pathways
IFN-gamma (zeige IFNG Proteine) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (zeige IFNG Proteine) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (zeige BCL2 Proteine).
IL 15 generates a dramatic expansion of short-lived memory CD8 (zeige CD8A Proteine) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (zeige CD4 Proteine)(+) and CD8 (zeige CD8A Proteine)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (zeige CD4 Proteine) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (zeige CD4 Proteine) on memory CD4 (zeige CD4 Proteine) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.