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The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
Data show that the let-7c/miR (zeige MLXIP Proteine)-99a/miR (zeige MLXIP Proteine)-125b cluster controlled tumorigenesis by targeting IL-6 (zeige IL6 Proteine), IL-6R and IGF1R (zeige IGF1R Proteine).
Our results argued that increased expression of sIL6R from myeloid cells and subsequent c-Maf (zeige MAF Proteine) induction were adverse events for counteracting tumor-specific Th1 (zeige TH1L Proteine) generation. Overall, this work provides a mechanistic rationale for sIL6R targeting to improve the efficacy of T-cell-mediated cancer immunotherapy
These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 (zeige ADAM17 Proteine) in regulating murine IL-6 (zeige IL6 Proteine) signals during inflammatory processes.
this study show that soluble IL-6R is infiltrating from the circulation in an ADAM17 (zeige ADAM17 Proteine)-independent process and is involved in the controlled resolution of an acute inflammatory episode
the sIL (zeige PMEL Proteine)-6R/p28 (zeige PSMD10 Proteine) fusion protein (FP) upregulated IFN-lambda1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 (zeige AFT1 Proteine) to the IFN-lambda1 promoter via the p38 MAPK (zeige MAPK14 Proteine) signaling pathway; results demonstrate the important role of sIL (zeige PMEL Proteine)-6R/p28 (zeige PSMD10 Proteine) FP in mediating virus-induced type III IFN production
Thus, trans-signaling of IL-6 can only occur via sIL-6R, but not sCD5.
The here presented data demonstrate that miR (zeige MLXIP Proteine)-451 may function as a potential suppressor of tumor growth, migration and angiogenesis in osteosarcoma via down-regulating IL 6R.
DNA hypomethylation of IL-6 (zeige IL6 Proteine) gene measured in blood leukocytes was associated with increased risk of ischemic heart disease.
minor allele, with the difference eliminated upon addition of tocilizumab. In conclusion, there is evidence that neutrophils may be an important source of sIL-6R in the lungs, and the Asp358Ala variant may have pro-inflammatory effects in lung cells.d However, we were unable to identify evidence for aisease
IL-6sR and gp130 (zeige ANPEP Proteine), but not IL-6R alpha, play important roles in regulation of granulosa cell survival
Mechanical injury potentiates the catabolic effects of TNFalpha (zeige TNF Proteine) and IL-6 (zeige IL6 Proteine)/sIL-6R in causing proteoglycan (zeige Vcan Proteine) degradation in human and bovine cartilage.
TNF (zeige TNF Proteine)/IL-6 (zeige IL6 Proteine) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (zeige NFATC1 Proteine), DNAX-activation protein 12 (zeige TYROBP Proteine), and cell proliferation
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Interleukin-6 receptor alpha may have a role in skin lesions in a murine model of systemic lupus erythematosus
findings identify TRAF3 (zeige TRAF3 Proteine) and PTPN22 (zeige PTPN22 Proteine) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (zeige TRAF3 Proteine) in the regulation of plasma cell differentiation
Data show that blockade of interleukin-6 receptor by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (zeige UGCG Proteine)) and inhibit the bone loss they cause.
established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (zeige ADAM17 Proteine) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (zeige ADAM10 Proteine)
Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
When endogenously released IL-6 (zeige IL6 Proteine) binds to Il-6Ralpha in brain the effect is pyrogenic.
metastasizing cancer cells induced higher MDSCs infiltration and prompted them to secret exaggerated IL-6 (zeige IL6 Proteine) as well as soluble IL-6Ra, which, in turn, triggered a persistent increase of pSTAT3 in tumor cells.
Cellular senescence or EGFR (zeige EGFR Proteine) signaling induces Interleukin 6 receptor expression controlled by mTOR (zeige FRAP1 Proteine).
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
interleukin 6 receptor
, interleukin 6 receptor alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, IL-6 receptor subunit alpha
, IL-6R 1
, membrane glycoprotein 80
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, IL-6 receptor alpha chain