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Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN803868
Pacheco, Oliva, Martinez-Navío, Climent, Ciruela, Gatell, Gallart, Mallol, Lluis, Franco: Glutamate released by dendritic cells as a novel modulator of T cell activation. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Rat (Rattus) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305130
McKnight, Barclay, Mason: Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells. in European journal of immunology 1991
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Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305127
Noma, Sideras, Naito, Bergstedt-Lindquist, Azuma, Severinson, Tanabe, Kinashi, Matsuda, Yaoita: Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. in Nature 1986
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Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305126
Paul: Interleukin-4: a prototypic immunoregulatory lymphokine. in Blood 1991
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Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN804054
Pacheco, Martinez-Navio, Lejeune, Climent, Oliva, Gatell, Gallart, Mallol, Lluis, Franco: CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. in Proceedings of the National Academy of Sciences of the United States of America 2005
Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1888633
Osusky, Teschke, Wang, Wong, Buckley: A chimera of interleukin 2 and a binding variant of aerolysin is selectively toxic to cells displaying the interleukin 2 receptor. in The Journal of biological chemistry 2008
Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN2004839
Tao, Yang, Jia, Wan, Cheng, Lu: Molecular cloning, recombinant expression and characterization of GMCSF from the rhesus monkey, Macaca mulatta. in Developmental and comparative immunology 2013
upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 (zeige CXCR4 Proteine) via phosphorylation of S339-CXCR4 (zeige CXCR4 Proteine) in order to activate a PREX1-Rac1-signaling pathway that stabilizes interleukin-2(IL-2 (zeige IL2 Proteine)), IL-4, and IL-10 (zeige IL10 Proteine) messenger RNA (mRNA) transcripts.
IL-4 signaling up-regulates the IL-25 (zeige IL25 Proteine) axis in human monocytic cells, and IL-25 (zeige IL25 Proteine) may provide autocrine signals in monocytes and macrophages to sustain IL-17Rb expression and predispose to alternative activation.
IL4 VNTR B2 allele was only significantly associated with overall adiposity status before adjusting for ethnicity.
Our results showed the role of IL4 in promoting breast cancer aggressiveness
These data identified the IL-4/CXCL12 (zeige CXCL12 Proteine) loop as a previously unrecognized pathway involved in lymphoid stroma polarization and as a potential therapeutic target in Follicular lymphoma patients.
IL-4 genetic variations associated with susceptibility to or protection against chronic periodontitis are directly associated with influencing the response of immune cells to periodontopathogens
in HIV/AIDS patients under antiretroviral therapy, IL-4 and IL-10 (zeige IL10 Proteine) levels were significantly lower in lipodystrophy vs. non-lipodystrophy
autologous CD4 (zeige CD4 Proteine)(+) T cells that are exposed to EVs from CD40 (zeige CD40 Proteine)/IL-4-stimulated CLL cells exhibit enhanced migration, immunological synapse signaling, and interactions with tumor cells.
IL-4 substantially restores CD79b (zeige CD79B Proteine) protein expression, sIgM expression, and BCR (zeige BCR Proteine) signaling.
Tandem repeat polymorphisms of IL4 is associated with the severity of chronic periodontitis.
These observations suggest that IL-4 and IL-13 (zeige IL13 Proteine) likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (zeige HAND1 Proteine) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
this study shows that eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2(-/-) mice
findings show that during intestinal helminth infection, IL-4 derived from T follicular helper cells is required for IgE class switching and plasmablast formation
Data suggest that Il4 (usually released from helper T-cells) induces Cox1 in macrophages at post-transcriptional level; activation of Ampk (zeige PRKAA1 Proteine) (catalytic subunit Prkaa1 (zeige PRKAA1 Proteine)) by metformin blocks Il4-dependent induction of Cox1 and blocks macrophage polarization/activation. (Il4 = interleukin-4; Cox1 = cyclooxygenase 1 (zeige PTGS1 Proteine); Ampk (zeige PRKAA1 Proteine) = AMP-activated protein kinase (zeige PRKAA2 Proteine))
IL-4 is required for the development of ex-Foxp3 (zeige FOXP3 Proteine) T helper 2 cells.
conclude that a state of haploinsufficiency for the Il4 gene locus is specifically relevant for IL-4-dependent IgE responses to allergens with the amount of IL-4 produced in the hemizygous condition falling close to the threshold required for switching to IgE production
priming of T helper cells by IL-6 (zeige IL6 Proteine)-deficient antigen-presenting dendritic cells preferentially leads to accumulation of a subset of Follicular helper T cells characterized by high expression of GATA3 (zeige GATA3 Proteine) and IL-4.
eosinophils drive progression of myocarditis to Inflammatory dilated cardiomyopathy (DCMi), cause severe DCMi when present in large numbers, and mediate this process through IL-4.
These data suggest that although IL-4-stimulated alternatively activated macrophages upregulate fatty acid oxidation, fatty acid oxidation is dispensable for macrophage polarization and high-fat diet-induced metabolic dysfunction. Macrophage fatty acid oxidation likely plays a correlative, rather than causative, role in systemic metabolic dysfunction.
Excessive IL-4 levels in the mesenteric lymph nodes (MLNs) directly inhibited the induction of aiTregs and caused enteropathy. The aiTregs generated in the attenuation of T cell-dependent food allergic enteropathy may function differently than aiTregs induced in a tolerance model.
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma (zeige IFNG Proteine) occurring after parturition and an increase in IL-4 production before calving.
IL-4 may play a role in coordinating the adrenal response to inflammatory stress.
T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 (zeige MMP1 Proteine) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
IL-4- and IL-10 (zeige IL10 Proteine)-producing invariant NKT (zeige SLC22A6 Proteine) cells inhibit the Th1 (zeige TH1L Proteine) cell response, but not the Th17 cell response
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.
The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.
unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 (zeige IL6 Proteine) secretion and suppresses antigen-stimulated proliferation of B cells
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.
IL-4 and STAT6 (zeige STAT6 Proteine) are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (zeige TH1L Proteine) biased, interferon-gamma (zeige IFNG Proteine) production is qualitatively similar to adult horses, and regulatory IL-10 (zeige IL10 Proteine) production by T cells is mature.
This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5 (zeige IL5 Proteine).
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.
Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
, B cell growth factor 1
, B_cell stimulatory factor 1
, lymphocyte stimulatory factor 1
, B-cell IgG differentiation factor
, B-cell growth factor 1
, B-cell stimulatory factor 1
, IGG1 induction factor
, B-cell IGG differentiation factor
, Lymphocyte stimulatory factor 1