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Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN803868
Pacheco, Oliva, Martinez-Navío, Climent, Ciruela, Gatell, Gallart, Mallol, Lluis, Franco: Glutamate released by dendritic cells as a novel modulator of T cell activation. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Rat (Rattus) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305130
McKnight, Barclay, Mason: Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells. in European journal of immunology 1991
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Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305127
Noma, Sideras, Naito, Bergstedt-Lindquist, Azuma, Severinson, Tanabe, Kinashi, Matsuda, Yaoita: Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. in Nature 1986
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Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305126
Paul: Interleukin-4: a prototypic immunoregulatory lymphokine. in Blood 1991
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Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN804054
Pacheco, Martinez-Navio, Lejeune, Climent, Oliva, Gatell, Gallart, Mallol, Lluis, Franco: CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. in Proceedings of the National Academy of Sciences of the United States of America 2005
Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1888633
Osusky, Teschke, Wang, Wong, Buckley: A chimera of interleukin 2 and a binding variant of aerolysin is selectively toxic to cells displaying the interleukin 2 receptor. in The Journal of biological chemistry 2008
Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN2004839
Tao, Yang, Jia, Wan, Cheng, Lu: Molecular cloning, recombinant expression and characterization of GMCSF from the rhesus monkey, Macaca mulatta. in Developmental and comparative immunology 2013
Cytokines (IFNg (zeige IFNG Proteine) and IL-4) estimation was done in the blood and NPA samples of cases and blood samples of controls.The mean levels of interleukin-4 in controls (blood), and cases (NPA and blood) were 1280.77, 956.08 and 692.37 pg/ml, respectively (P<0.05).
In this review, we discuss the molecular mechanisms driving IL-4 production in Th2 and Tfh cells.
In this review, we discuss the structural details of IL-4 and IL-4Ralpha subunit and the structural similarities between IL-4 and IL-13 (zeige IL13 Proteine). We also describe detailed chemistry of type-I and type-II receptor complexes and their signaling pathways. Furthermore, we elaborate the strength of type-II hetero dimer signals in response to IL-4 and IL-13 (zeige IL13 Proteine).
The obtained data demonstrate that the high level of production of IL-1b (zeige IL1B Proteine) and IL-4 in GN patients causes hypothyroidism resulting in the formation of nephrotic syndrome.
IL-4 and IL-17 (zeige IL17A Proteine) modulate the functional activity of phagocytes in the maternal blood, cord blood, and colostrum of diabetic mother.
Results showed that plasma and mRNA levels of IL-2 (zeige IL2 Proteine), IFN-gamma (zeige IFNG Proteine), IL-4, and IL-17A (zeige IL17A Proteine) in primary immune thrombocytopenia patients did not change significantly after TPO (zeige THPO Proteine)-RA treatment, whereas TGF-beta1 (zeige TGFB1 Proteine) levels increased remarkably.
Modulation of IL-2 (zeige IL2 Proteine), IL-4, IFN-gamma (zeige IFNG Proteine) and/or TNF-alpha (zeige TNF Proteine) levels, or inhibitors of Erk1/2 or S6K1 (zeige RPS6KB1 Proteine) may be a new approach to prevent BAFF (zeige TNFSF13B Proteine)-induced aggressive B-cell malignancies.
There was no significant difference in serum level of IL-4 between children with MPP (Mycoplasma pneumoniae pneumonia)and those with non-MPP. Among children with MPP, we found similar level of IL-4 regardless of the personal and family history of allergy and asthma or the presence of wheezing.
The functional promoter polymorphisms IL4-590C/T and IL6 (zeige IL6 Proteine)-174G/C, which affect the IL-4 and IL-6 (zeige IL6 Proteine) levels in north Indian subjects, were associated with kidney dysfunction and CKD
Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.
we defined a molecular mechanism for IL-4 downregulation of involucrin (zeige IVL Proteine) in keratinocytes, which may play an important role in the pathogenesis of AD.
In this study, the effect of continuous IL-4 delivery or bioactive implant coating that constitutively releases a protein inhibitor of CCL2 (zeige CCL2 Proteine) signaling (7ND) on particle induced osteolysis were studied in the murine continuous femoral intramedullary particle infusion model
T follicular helper (Tfh) cells arise in tumor-draining lymph nodes where they produce an abundance of IL4. Deletion of IL4-expressing Tfh cells improves antitumor immunity, delays tumor growth, and reduces the generation of immunosuppressive myeloid cells in the lymph nodes.
Findings suggest that interleukin 4 (IL-4) affects anti-tumor immunity and constitutes an attractive therapeutic target to reduce immune suppression in the tumor microenvironment.
this study shows that environmental IL-4 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 and IL-13 (zeige IL13 Proteine) are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
These observations suggest that IL-4 and IL-13 (zeige IL13 Proteine) likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (zeige HAND1 Proteine) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
this study shows that eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2(-/-) mice
findings show that during intestinal helminth infection, IL-4 derived from T follicular helper cells is required for IgE class switching and plasmablast formation
Data suggest that Il4 (usually released from helper T-cells) induces Cox1 in macrophages at post-transcriptional level; activation of Ampk (zeige PRKAA1 Proteine) (catalytic subunit Prkaa1 (zeige PRKAA1 Proteine)) by metformin blocks Il4-dependent induction of Cox1 and blocks macrophage polarization/activation. (Il4 = interleukin-4; Cox1 = cyclooxygenase 1 (zeige PTGS1 Proteine); Ampk (zeige PRKAA1 Proteine) = AMP-activated protein kinase (zeige PRKAA2 Proteine))
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma (zeige IFNG Proteine) occurring after parturition and an increase in IL-4 production before calving.
IL-4 may play a role in coordinating the adrenal response to inflammatory stress.
T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 (zeige MMP1 Proteine) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
IL-4- and IL-10 (zeige IL10 Proteine)-producing invariant NKT (zeige SLC22A6 Proteine) cells inhibit the Th1 (zeige TH1L Proteine) cell response, but not the Th17 cell response
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.
The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.
unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 (zeige IL6 Proteine) secretion and suppresses antigen-stimulated proliferation of B cells
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.
IL-4 and STAT6 (zeige STAT6 Proteine) are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (zeige TH1L Proteine) biased, interferon-gamma (zeige IFNG Proteine) production is qualitatively similar to adult horses, and regulatory IL-10 (zeige IL10 Proteine) production by T cells is mature.
This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5 (zeige IL5 Proteine).
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.
Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
, B cell growth factor 1
, B_cell stimulatory factor 1
, lymphocyte stimulatory factor 1
, B-cell IgG differentiation factor
, B-cell growth factor 1
, B-cell stimulatory factor 1
, IGG1 induction factor
, B-cell IGG differentiation factor
, Lymphocyte stimulatory factor 1