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Taken together, this work suggests that IFNa (zeige IFNA Proteine) provides protection of salmon against SAV3 locally in an infected area while IFNb (zeige IFNB1 Proteine) and IFNc provides systemic protection against the virus.
IFNa (zeige IFNA Proteine) is the main IFN subtype induced through salmon RIG-I (zeige DDX58 Proteine)/viral RNA receptor MDA5 (zeige IFIH1 Proteine) pathway in lymphoid tissues.
These findings also identify STAT3 (zeige STAT3 Proteine) as a therapeutic target against viral infection and highlight it as an essential pathway component for endogenous and therapeutic IFN-alpha (zeige IFNA Proteine) responsiveness.
the close association between the increased proportion of CD180 (zeige CD180 Proteine)-negative B cells and the activation of IFN-alpha (zeige IFNA Proteine) signaling in Systemic lupus erythematosus, is reported.
IL-12 (zeige IL12A Proteine) and IFN-alpha (zeige IFNA Proteine) differentially program CD8 (zeige CD8A Proteine) T cells to re-express distinct levels of PD-1 (zeige PDCD1 Proteine) upon re-encountering Ag, resulting in IL-12 (zeige IL12A Proteine)-stimulated cells being less susceptible to exhaustion in the face of sustained tumor Ag.
The expansion of CD8 (zeige CD8A Proteine) T cells depends on type I IFN, type I IFN and IL-12 (zeige IL12A Proteine) or is largely independent of the two cytokines.
A spontaneous genomic duplication and frameshift mutation in the guanine exchange factor dedicator of cytokinesis 2 (Dock2) that has arisen in at least a subset of circulating Irf5(-/-) mice and inadvertently been bred to homozygosity.
Knockdown of endogenous guanylate binding protein (GBP)4 (zeige GBP4 Proteine) increases IRF7 (zeige IRF7 Proteine)-mediated IFN-alpha (zeige IFNA Proteine) production, whereas overexpression of GBP4 (zeige GBP4 Proteine) has the opposite effect.
Data show that similar T cell expansion and serum IgG responses were observed in adenovirus (Adv (zeige AVIL Proteine))-IFN-treated WT and BAFF (zeige TNFSF13B Proteine)-deficient mice despite their disparate pathological and clinical responses.
Studies in both mice and humans have demonstrated a role for IFN-alpha (zeige IFNA Proteine)/beta in directly influencing the fate of both CD4 (zeige CD4 Proteine)(+) and CD8 (zeige CD8A Proteine)(+) T cells during the initial phases of antigen recognition.
IFN-alpha (zeige IFNA Proteine) enhances both the induction and maintenance of programmed cell death (PD)-1 (zeige PDCD1 Proteine) expression on T cell receptor-engaged primary mouse T cells through association of IFN-responsive factor 9 (IRF9 (zeige IRF9 Proteine)) with the IFN stimulation response element.
This article reports the production of interferon alpha (zeige IFNA Proteine)/beta (IFN-alpha (zeige IFNA Proteine)/beta) by SJL/J mouse brain astrocyte cultures infected with Theiler's murine encephalomyelitis virus (TMEV).
results demonstrate that Sphingosine 1-phosphate lyase (SPL (zeige SGPL1 Proteine)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon (zeige IKBKE Proteine) and SPL (zeige SGPL1 Proteine), which provides a mechanistic understanding of the pro-IFN activity of SPL (zeige SGPL1 Proteine)
These data suggest that plasmacytoid dendritic cells producing IFN-alpha (zeige IFNA Proteine) and IL-33 (zeige IL33 Proteine) play a pivotal role in the chronic fibro-inflammatory responses underlying murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis.
Mothers of children affected by autoimmune congenital heart block had a significantly higher expression IFN-alpha (zeige IFNA Proteine).
Suppression of the exogenous Type I IFN-induced Jak (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling by NSs might be one of the mechanisms of Severe fever with thrombocytopenia syndrome (SFTS) to evade host immune surveillance.
High Type I Interferon (zeige IFNA Proteine) expression due to hypomethylation is associated with Systemic Lupus Erythematosus.
these studies identify phosphorylation of S734-STAT2 (zeige STAT2 Proteine) as a new regulatory mechanism that negatively controls the type I IFN-antiviral response.
The synthetic IFNP molecule exerted its antitumor activity by upregulating the downstream genes involved in the STAT1 (zeige STAT1 Proteine) pathway and in apoptosis. Using a cell receptor binding assay, we showed that this Jurkat-binding peptide (zeige HP Proteine) facilitated the binding affinity of IFNalpha to the cell surface type I IFN receptor
KSHV-encoded viral IRF4 (zeige IRF4 Proteine) interacts with the host IRF7 (zeige IRF7 Proteine) and inhibits interferon-alpha (zeige IFNA Proteine) production.
Data indicate ARID3a (zeige ARID3A Proteine)(+) B cells as a type of effector B cell, and link ARID3a (zeige ARID3A Proteine) expression in B lymphocytes to interferon alpha (IFNa (zeige IFNA Proteine))-associated inflammatory responses in systemic lupus erythematosus (SLE).
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (zeige IFNA Proteine) response by inducing STAT1 (zeige STAT1 Proteine) degradation.
Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 (zeige IRF3 Proteine) and subsequent degradation of IRF-3 (zeige IRF3 Proteine), leading to downregulation of IFN-alpha (zeige IFNA Proteine)/beta production.
Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.
Overall, data provide evidence for the possible role of PI3K in the activation of the transcription of IFN-alpha (zeige IFNA Proteine)/beta by PRRSV; study concludes that PRRSV inhibits the induction of IFN-alpha (zeige IFNA Proteine) in monocyte-derived dendritic cells by as yet undefined post-transcriptional mechanisms.
Nsp1beta inhibits interferon-activated (zeige MNDA Proteine) STAT1 (zeige STAT1 Proteine)/STAT2 (zeige STAT2 Proteine) signal transduction by inducing karyopherin-alpha1 degradation.
Expression of Mx protein (zeige MX2 Proteine) and interferon-alpha (IFN-alpha (zeige IFNA Proteine)) was examined by immunohistochemistry in pigs experimentally infected with swine influenza virus.
Foot-and-Mouth Disease Virus inhibits IFN-alpha (zeige IFNA Proteine) expression in infected cells by blocking cap-dependent translation.
The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted.
, interferon alpha 1
, interferon alpha 13
, interferon alpha family gene 1
, interferon alpha-1
, IFN-alpha 1
, interferon-alpha 1
, IFN-alpha 1b
, interferon alpha 1b
, interferon alpha-D
, leIF D