anti-Maus IFNA Antikörper für Immunoassay

Recommended IFNA Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interferon alpha (IFNA) Antikörper
  • IFL
  • IFN
  • IFN-ALPHA
  • IFN-alphaD
  • IFNA13
  • IFNA@
  • IFN-ALPHA-1
  • IFN1@
  • Ifa
  • Ifa8
  • IFN-a
  • IFN-alpha1
  • interferon alpha 1
  • interferon, alpha 1
  • interferon alpha
  • interferon alpha-A
  • interferon-alpha 1
  • interferon-alpha
  • IFNA1
  • Ifna
  • IFNAA
  • Ifna1
  • IFNA
Reaktivität
Maus
130
22
13
13
10
7
7
5
2
2
2
1
Wirt
Ratte
114
69
13
6
3
2
1
Klonalität
Monoklonal
Konjugat
Dieser IFNA Antikörper ist unkonjugiert
11
10
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Applikation
Functional Studies (Func), Immunoassay (IA), Flow Cytometry (FACS), Western Blotting (WB)
148
147
44
39
34
33
28
28
21
15
10
9
6
3
2
2
1
1
1
1
1
Optionen
Hersteller
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Produktnummer ABIN2191742
$ 362.70
Zzgl. Versandkosten $45.00

General

Antigen Interferon alpha (IFNA) Antikörper
Reaktivität Maus
(130), (22), (13), (13), (10), (7), (7), (5), (2), (2), (2), (1)
Wirt Ratte
(114), (69), (13), (6), (3), (2), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser IFNA Antikörper ist unkonjugiert
(11), (10), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Applikation Functional Studies (Func), Immunoassay (IA), Flow Cytometry (FACS), Western Blotting (WB)
(148), (147), (44), (39), (34), (33), (28), (28), (21), (15), (10), (9), (6), (3), (2), (2), (1), (1), (1), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IFNA Antikörper

Target Details IFNA Anwendungsinformationen Handhabung Referenzen für anti-IFNA Antikörper (ABIN2191742) Bilder
Kreuzreaktivität (Details) Cross reactivity: Human IFN : No, Mouse IFN-β : No, : No, Mouse IFN-: No
Sterilität 0.2 μm filtered
Klon F18
Isotyp IgG1

Target Details IFNA

Produktdetails anti-IFNA Antikörper Anwendungsinformationen Handhabung Referenzen für anti-IFNA Antikörper (ABIN2191742) Bilder zurück nach oben
Antigen
Andere Bezeichnung Interferon-alpha (IFNA Antibody Abstract)
Hintergrund The monoclonal antibody F18 recognizes and neutralizes both natural and recombinant mouse alpha Interferon (IFN-α). IFN-α is a cytokine that belongs to the type I interferons (IFN-I). IFN-α is secreted by many cell types including lymphocytes (NK cells, B-cells and T-cells), macrophages, fibroblasts, endothelial cells, osteoblasts, microglia and others. Interferons stimulate both macrophages and NK cells to elicit an anti-viral response, and are also active against tumors. Although all cells can produce IFN-I, plasmacytoid dendritic cells (pDCs) produce 1,000-fold higher levels than other cell types, and are responsible for systemic IFN-I responses to many viruses. They are coined as the natural IFN- producing cells. However, under deprived pDC condition, other dendritic cells are capable of producing high levels of IFN-I. Interferons were initially characterized for their ability to 'interfere' with viral replication, slow cell proliferation, and profoundly alter immunity. IFN-α has several regulatory roles and diverse biological activities, including control of cellular and humoral immune responses, inflammation, and tumor regression. In addition, IFN-α participates in the regulation of various cellular and humoral processes such as the endocrine system modulates behavior, brain activity, temperature, glucose sensitive neurons, feeding pattern and opiate activity. With the availability of monoclonal antibodies directed against IFN-α, it is possible to interpret results obtained from crude materials containing both IFN-α and IFN-β. The difficulties in studying in vitro and in vivo effects of 'type 1' Interferons arise from the fact that both alpha and beta Interferons are produced in response to the same stimuli and also seem to act via the same receptor. These Interferon activities can only be distinguished from one another by use of specific neutralizing antibodies. Aliases IFN-α
Pathways JAK-STAT Signalweg, Hepatitis C

Anwendungsinformationen

Produktdetails anti-IFNA Antikörper Target Details IFNA Handhabung Referenzen für anti-IFNA Antikörper (ABIN2191742) Bilder zurück nach oben
Applikationshinweise For flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. 1
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IFNA Antikörper Target Details IFNA Anwendungsinformationen Referenzen für anti-IFNA Antikörper (ABIN2191742) Bilder zurück nach oben
Buffer PBS, containing 0.1 % bovine serum albumin.
Lagerung 4 °C
Informationen zur Lagerung Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Referenzen für anti-IFNA Antikörper (ABIN2191742)

Produktdetails anti-IFNA Antikörper Target Details IFNA Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Joshi, Kalvakolanu, Chen, Zhang, Kang, Thomas, Vogel, Cross: "A role for Stat1 in the regulation of lipopolysaccharide-induced interleukin-1beta expression." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 26, Issue 10, pp. 739-47, 2006

Diebold, Montoya, Unger, Alexopoulou, Roy, Haswell, Al-Shamkhani, Flavell, Borrow, Reis e Sousa: "Viral infection switches non-plasmacytoid dendritic cells into high interferon producers." in: Nature, Vol. 424, Issue 6946, pp. 324-8, 2003