anti-Human HTR1D Antikörper für Western Blotting

Recommended HTR1D Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Serotonin Receptor 1D (HTR1D) Antikörper
  • AI853647
  • Gpcr14
  • Htr1db
  • 5-HT1D
  • HT1DA
  • HTR1DA
  • HTRL
  • RDC4
  • 5HT1D
  • 5-HT-1D
  • 5-hydroxytryptamine (serotonin) receptor 1D
  • 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
  • Htr1d
  • HTR1D
Epitop
N-Term, AA 14-27, Extracellular Loop
14
10
7
6
5
4
2
2
2
1
1
1
1
1
Reaktivität
Human, Ratte (Rattus)
35
31
17
3
2
2
Wirt
Kaninchen
54
Klonalität
Polyklonal
Konjugat
Dieser HTR1D Antikörper ist unkonjugiert
2
2
2
2
2
2
Applikation
Western Blotting (WB)
31
23
14
3
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN1741997
$ 821.43
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
3.2182703 ABIN1741998 WB Rabbit N-Term, AA 14-27, Extracellular Loop Anmelden zum Anzeigen Polyclonal 2
3.2182703 ABIN252329 SimWes WB Rabbit Anmelden zum Anzeigen Polyclonal 2
3.2182703 ABIN2705358 WB Rabbit Center Anmelden zum Anzeigen Polyclonal
1 ABIN290355 IHC (p) WB Rabbit IgG AA 1-18 Anmelden zum Anzeigen Polyclonal
1 ABIN372425 IHC (p) WB Rabbit IgG AA 1-18, AA 251-267, N-Term Anmelden zum Anzeigen Polyclonal
1 ABIN2470118 IHC WB Rabbit IgG AA 1-18 Anmelden zum Anzeigen Polyclonal
1 ABIN354160 WB Rabbit IgG AA 1-18 Anmelden zum Anzeigen Polyclonal
1 ABIN2622217 ELISA WB Rabbit IgG AA 271-301 Anmelden zum Anzeigen Polyclonal
1 ABIN2622218 WB Rabbit Internal Region Anmelden zum Anzeigen Polyclonal
1 ABIN2886795 WB Rabbit Anmelden zum Anzeigen Polyclonal
1 ABIN1808514 WB Rabbit AA 272-301 Anmelden zum Anzeigen Polyclonal
1 ABIN5618655 WB Rabbit Center Anmelden zum Anzeigen Polyclonal
1 ABIN4276867 SimWes WB Rabbit Anmelden zum Anzeigen Polyclonal

General

Antigen Serotonin Receptor 1D (HTR1D) Antikörper
Epitop N-Term, AA 14-27, Extracellular Loop
(14), (10), (7), (6), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Reaktivität Human, Ratte (Rattus)
(35), (31), (17), (3), (2), (2)
Wirt Kaninchen
(54)
Klonalität
Polyklonal
Konjugat Dieser HTR1D Antikörper ist unkonjugiert
(2), (2), (2), (2), (2), (2)
Applikation Western Blotting (WB)
(31), (23), (14), (3), (2)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-HTR1D Antikörper

Target Details HTR1D Anwendungsinformationen Handhabung Referenzen für anti-HTR1D Antikörper (ABIN1741997) Bilder
Sequenz (C)EASNRSLNAT GAWD
Kreuzreaktivität (Details) Mouse - identical, human - AA 13-14 residues identical.
Produktmerkmale Peptide Confirmation:
Confirmed by amino acid analysis.

Buffer after reconstitution:
Phosphate buffered saline (PBS), pH 7.4, 1 % BSA, 0.05 % NaN3.

Antibody concentration after reconstitution:
0.8 mg/mL

Preadsorption Control:
1 µg peptide per 1 µg antibody.

GPCR
Reinigung Affinity purified on immobilized antigen
Immunogen Peptide corresponding to amino acid residues 14-27 of rat 5-hydroxytryptamine receptor 1D. Extracellular, N-terminus.

Target Details HTR1D

Produktdetails anti-HTR1D Antikörper Anwendungsinformationen Handhabung Referenzen für anti-HTR1D Antikörper (ABIN1741997) Bilder zurück nach oben
Antigen
Andere Bezeichnung 5-Hydroxytryptamine Receptor 1D (HTR1D Antibody Abstract)
Hintergrund Synonyms:
5-HT1D, Serotonin receptor 1D

Serotonin (5-hydroxytryptamine, 5-HT) plays unequivocally a most important role in the normal physiology amongst higher eukaryotes, as do most neurotransmitters. The physiological roles of serotonin and its receptors range from appetite, regulation of the circadian rhythm, sexual behavior, memory and nociception. Serotonin is also involved in migraine and some psychiatric diseases such as depression anxiety and aggression1. Serotonin and its receptors also have an influence on the cardiovascular, pulmonary, gastrointestinal (GI) and genitourinary systems2. To date, some fifteen serotonin receptors have been cloned and grouped into seven families (5-HT1-5-HT7) based on their signaling mechanisms. The 5-HT1 receptor class comprises 5 different receptors with ranging homology. Apart from 5-HT3, all serotonin receptors belong to the G-Protein Coupled Receptor superfamily and therefore span the membrane seven times3. Members of 5-HT1 receptor class all couple Gi/0 thereby inhibiting adenylate cyclase. In the central nervous system, 5-HT1D is expressed in the basal ganglia, hippocampus and cortex in rat and in the basal ganglia, midbrain and spinal cord in human. In serotonin neurons, 5-HT1D receptors are autoreceptors thereby inhibiting the release of 5-HT. In GABA, ACh, and glutamate neurons they are heteroreceptors where they control the release of these neurotransmitters4,5. As mentioned above, the serotonin system plays an undeniable role in the perception and processing of pain. Indeed, many migraine sufferers are prescribed triptan-based drugs which activate 5-HT1B and 5-HT1D receptors2. It has been designed to recognize 5-Hydroxytryptamine Receptor 1D from human, rat and mouse samples.
Gen-ID 25323
UniProt P28565
Pathways JAK-STAT Signalweg

Anwendungsinformationen

Produktdetails anti-HTR1D Antikörper Target Details HTR1D Handhabung Referenzen für anti-HTR1D Antikörper (ABIN1741997) Bilder zurück nach oben
Applikationshinweise Recommended Dilution:
WB: approx. 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-HTR1D Antikörper Target Details HTR1D Anwendungsinformationen Referenzen für anti-HTR1D Antikörper (ABIN1741997) Bilder zurück nach oben
Format Lyophilized
Rekonstitution 0.2 mL deionized water.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid multiple freezing and thawing.
Centrifuge all antibody preparations before use (10000 x g 5 min).
Lagerung 4 °C/-20 °C
Informationen zur Lagerung The reconstituted solution can be stored at 4 °C for up to 2 weeks. For longer periods, small aliquots should be stored at -20 °C or below. The further dilutions should be made using a carrier protein such as BSA (1 %).

Referenzen für anti-HTR1D Antikörper (ABIN1741997)

Produktdetails anti-HTR1D Antikörper Target Details HTR1D Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Filip, Bader: "Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system." in: Pharmacological reports : PR, Vol. 61, Issue 5, pp. 761-77, 2009

Fink, Göthert: "5-HT receptor regulation of neurotransmitter release." in: Pharmacological reviews, Vol. 59, Issue 4, pp. 360-417, 2007

Bilder

Produktdetails anti-HTR1D Antikörper Target Details HTR1D Anwendungsinformationen Handhabung Referenzen für anti-HTR1D Antikörper (ABIN1741997) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Serotonin Receptor 1D (HTR1D) (AA 14-27), (Extracellular Loop), (N-Term) antibody (ABIN1741997) Western blot analysis of rat prostate (lanes 1 and 3) and PC-3 cell (lanes 2 and 4) l...