GNAQ Proteine (GNAQ)

Bezeichnung:
Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide Proteine (GNAQ)
Auf www.antikoerper-online.de finden Sie aktuell 13 Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen GNAQ Antikörper (85) und GNAQ Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 108 GNAQ Produkte verfügbar.
Synonyme:
1110005L02Rik, 6230401I02Rik, AA408290, AW060788, CMC1, Dsk1, Dsk10, g-alpha-q, Galphaq, gaq, Gnaq, gnaqb, Gq, GqI, si:ch73-270f14.2, SWS
alle Proteine anzeigen Gen GeneID UniProt
GNAQ 2776 P50148
GNAQ 81666 P82471
GNAQ 14682 P21279

Weitere Synonyme anzeigen

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Weitere Proteine zu GNAQ Interaktionspartnern

Human Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) Interaktionspartner

  1. Data (including data from studies using cells from knockout mice) suggest that CLEC2 (zeige CLEC1B Proteine)/CLEC2R signaling is dependent on thromboxane A2 generation and is potentiated by co-stimulation with different GNAQ agonists. (CLEC2 (zeige CLEC1B Proteine) = C-type lectin (zeige MBL2 Proteine) CLEC2 (zeige CLEC1B Proteine); CLEC2R = CLEC2 (zeige CLEC1B Proteine) receptor; GNAQ = guanine nucleotide-binding protein (zeige COASY Proteine) G[q] subunit alpha)

  2. The findings of the work indicate a role for Galphaq and/or Galpha14 and in CCR2a/CCR2b (zeige CCR2 Proteine)-stimulated Rho A (zeige RHOA Proteine) GTPase (zeige RACGAP1 Proteine)-mediated serum response factor activation.

  3. GNAQ/11 mutant clones make up a fraction of the cells in choroidal nevi. Nevus cells are furthermore characterised by heterogeneous YAP (zeige YAP1 Proteine) expression. Combined GNAQ/11 and YAP (zeige YAP1 Proteine) may constitute a putative precursor tumour pathway with an activated oncogene (zeige RAB1A Proteine) (GNAQ/11) and downstream effector (YAP (zeige YAP1 Proteine)).

  4. RasGRP3 (zeige RASGRP3 Proteine) mediates ERK MAPK (zeige MAPK1 Proteine) pathway activation in GNAQ mutant uveal melanoma.

  5. Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (zeige TH1L Proteine) differentiation

  6. The GC/GC (zeige GC Proteine) genotype of the TT(-695/-694)GC polymorphism is associated with increased Gq protein expression, augmented angiotensin II receptor type 1 (zeige AGTR1 Proteine)-related vasoconstriction, and increased myocardial injury after coronary artery bypass grafting.

  7. we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ, GNA11 (zeige GNA11 Proteine), and EIF1AX (zeige EIF1AX Proteine) mutations.

  8. Data suggest that allosteric communication between heterodimeric AT1R and PTGFR is mediated through GNAQ and may also involve proximal phospholipase C but not distal protein kinase C signaling partners; PTGFR activation has negligible effects on AT1R-based conformational biosensors. (AT1R = angiotensin II receptor, type 1; PTGFR = prostaglandin F2alpha receptor; GNAQ = GTP-binding protein G[q] subunit alpha)

  9. GNAQ and GNA11 mutations occur frequently in mucosal melanoma and may be a prognostic factor for MM. Our data implicate that GNAQ/11 may be potential targets for targeted therapy of mucosal melanoma.

  10. Results found that GNAQ was highly expressed in gastric cancer (GC) patient samples and suggest that GNAQ plays a critical role in regulating GC cell growth and survival via canonical oncogenic signaling pathways including MAPK (zeige MAPK1 Proteine) and p53 (zeige TP53 Proteine).

Pig (Porcine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) Interaktionspartner

  1. The Galphas (zeige GNAS Proteine) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (zeige AVPR1A Proteine), respectively. The beta2-AR/Galphas (zeige GNAS Proteine) peptide interface is dominated by electrostatic interactions, whereas the V1AR (zeige AVPR1A Proteine)/Galphaq peptide interactions are predominantly hydrophobic.

  2. The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog.

Cow (Bovine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) Interaktionspartner

  1. atomic structure of GRK2 (zeige ADRBK1 Proteine) in complex with Galphaq and Gbetagamma, in which the activated Galpha (zeige SUCLG1 Proteine) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [g alphaq]

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) Interaktionspartner

  1. Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (zeige HAND1 Proteine) differentiation

  2. Fluid shear stress acts on the Galphaq-ERK5 (zeige MAPK7 Proteine) signaling pathway to upregulate Cyclin B1 (zeige CCNB1 Proteine) and CDK1 (zeige CDK1 Proteine) expression, thereby resulting in MC3T3-E1 cell proliferation.

  3. activation of the Gq-membrane-associated estrogen receptors rapidly stimulates hypothalamic paraventricular nucleus CRH (zeige CRH Proteine) neurons by suppressing the M-current and potentiating glutamatergic neurotransmission

  4. cell-penetrating peptides should effectively inhibit active Galphaq in cells and that these and genetically encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor the spatiotemporal activation of Galphaq in cells.

  5. The Galphas (zeige GNAS Proteine) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (zeige AVPR1A Proteine), respectively. The beta2-AR/Galphas (zeige GNAS Proteine) peptide interface is dominated by electrostatic interactions, whereas the V1AR (zeige AVPR1A Proteine)/Galphaq peptide interactions are predominantly hydrophobic.

  6. the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.

  7. The betaARKrgs peptide, but not endogenous GRK2 (zeige ADRBK1 Proteine), interacted with Galpha(q) and interfered with signaling through this G protein. These data support the development of GRK2 (zeige ADRBK1 Proteine)-based therapeutic approaches to prevent hypertrophy and heart failure.

  8. Galphaq/Galpha11 signaling pathways play a pivotal role in gene activity patterns during cardiac remodeling.

  9. Developmental AHR activation by pollutants, and other exogenous ligands, increases the likelihood that Gnaq knockout mice will develop autoimmune diseases later in life.

  10. demonstrate that the ability of an MC4R (zeige MC4R Proteine) agonist delivered to PVN to inhibit food intake is lost in mice lacking G(q/11)alpha in the paraventricular nucleus of the hypothalamus but not in animals deficient for G(s)alpha

GNAQ Protein Überblick

Protein Überblick

This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.

Alternative names and synonyms associated with GNAQ

  • guanine nucleotide binding protein (G protein), q polypeptide (gnaq)
  • guanine nucleotide binding protein (G protein), q polypeptide (GNAQ)
  • guanine nucleotide binding protein (G protein), q polypeptide (Gnaq)
  • guanine nucleotide binding protein (G protein), q polypeptide (gnaq-b)
  • guanine nucleotide binding protein, alpha q polypeptide (Gnaq)
  • 1110005L02Rik Protein
  • 6230401I02Rik Protein
  • AA408290 Protein
  • AW060788 Protein
  • CMC1 Protein
  • Dsk1 Protein
  • Dsk10 Protein
  • g-alpha-q Protein
  • Galphaq Protein
  • gaq Protein
  • Gnaq Protein
  • gnaqb Protein
  • Gq Protein
  • GqI Protein
  • si:ch73-270f14.2 Protein
  • SWS Protein

Bezeichner auf Proteinebene für GNAQ

Galpha q , gnaqa , guanine nucleotide-binding protein G(q) subunit alpha , guanine nucleotide-binding protein alpha-q , G alpha q , guanine nucleotide binding protein alpha q subunit , guanine nucleotide binding protein, alpha q polypeptide , guanine nucleotide regulatory protein G alpha q , heterotrimeric guanine nucleotide-binding protein alpha q subunit , guanine nucleotide-binding protein G(q) alpha subunit

GENE ID SPEZIES
570108 Danio rerio
2776 Homo sapiens
403928 Canis lupus familiaris
81666 Rattus norvegicus
427262 Gallus gallus
654405 Sus scrofa
536654 Bos taurus
399261 Xenopus laevis
14682 Mus musculus
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