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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN2017902
Djalilian, Caicedo, Lessan, Grami, Le, Spellman, Pambuccian, Hall, Low, Ondrey: Efficacy of an osmotic pump delivered, GM-CSF-based tumor vaccine in the treatment of upper aerodigestive squamous cell carcinoma in rats. in Cancer immunology, immunotherapy : CII 2007
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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN803898
Carreño, Pacheco, Gutierrez, Jacobelli, Kalergis: Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells. in Immunology 2010
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Mouse (Murine) CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN803901
Bråve, Ljungberg, Boberg, Rollman, Isaguliants, Lundgren, Blomberg, Hinkula, Wahren: Multigene/multisubtype HIV-1 vaccine induces potent cellular and humoral immune responses by needle-free intradermal delivery. in Molecular therapy : the journal of the American Society of Gene Therapy 2005
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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN934919
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
TRAF6 (zeige TRAF6 Proteine) is also required for GM-CSF-induced ubiquitination and activation of Akt (zeige AKT1 Proteine).
Upregulation of GM-CSF and M-CSF (zeige CSF1 Proteine) production by endothelial cells, an effect that appears to be mediated by NF-kappaB (zeige NFKB1 Proteine) and to be independent of IL-1 (zeige IL1A Proteine), may be an additional mechanism through which IL-33 (zeige IL33 Proteine) contributes to inflammatory activation of the vessel wall.
Oral and periodontal innate immunity is affected by HIV viremia and ART. GCF (zeige GUCY2F Proteine) IL-8 (zeige IL8 Proteine), G-CSF (zeige CSF3 Proteine), as well as serum IL-8 (zeige IL8 Proteine), MCP-1 (zeige CCL2 Proteine) and GM-CSF may be useful biomarkers for the detection of disease presence and/or its severity due to HIV infection and ART use.
Data suggest that the intratumoral GM-CSF expression, as a potentially independent prognostic biomarker for recurrence, might improve conventional clinical and pathologic analysis to refine outcome prediction for clinically localized clear-cell renal cell carcinoma (zeige MOK Proteine) (ccRCC) patients after surgery.
High GM-CSF expression is associated with breast Cancer.
In gastric cancer (GC), tumour-derived GM-CSF activated neutrophils and induced neutrophil PD-L1 (zeige CD274 Proteine) expression via Janus kinase (JAK (zeige JAK3 Proteine))-signal transducer and activator of transcription 3 (STAT3 (zeige STAT3 Proteine)) signalling pathway. The activated PD-L1 (zeige CD274 Proteine)(+) neutrophils effectively suppressed normal T-cell immunity in vitro and contributed to the growth and progression of human GC in vivo.
The IL-3 (zeige IL-3 Proteine)/ GM-CSF effected on the myofibroblastic differentiation of human adipose derive stromal cells (hASCs) as well as it did on human dermal fibroblasts (HDFs).
Obesity alters the lung neutrophil infiltration to enhance breast cancer metastasis through IL5 (zeige IL5 Proteine) and GM-CSF.
Data suggest that the methylotrophic yeast Pichia pastoris is an effective recombinant host for heterologous granulocyte-macrophage colony-stimulating factor (rhGM-CSF) production.
Letter: Knockdown of either filaggrin (zeige FLG Proteine) or loricrin (zeige LOR Proteine) increases the productions of interleukin (IL)-1alpha, IL-8 (zeige IL8 Proteine), IL-18 (zeige IL18 Proteine) and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes.
Impaired RASGRF1 (zeige RASGRF1 Proteine)/ERK (zeige EPHB2 Proteine)-mediated GM-CSF response characterizes CARD9 (zeige CARD9 Proteine) deficiency in French-Canadians.
These results demonstrated that bovine colonic cells seem capable to respond to E. bovis merozoite I infection by the upregulation of CXCL10 (zeige CXCL10 Proteine) and GM-CSF gene transcription.
Data suggest exposure to maternal CSF2 from D5-D7 of development is fundamentally different for female/male blastocysts with respect to embryo elongation, characteristics of transcriptome/methylome, and endometrial interferon tau secretion at D15 (zeige MRPL16 Proteine).
The increase in calving rate caused by CSF2 treatment involves, in part, more extensive development of extraembryonic membranes and capacity of the conceptus to secrete IFNT2 at day 15 of pregnancy.
immunolocalization studies confirmed the presence of granulocyte-macrophage colony stimulating factor(GM-CSF) in the germ cell line in bovine and human testes and addition of GM-CSF enhances several parameters of sperm motility
the conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 (zeige PTGS2 Proteine) and GM-CSF during the peri (zeige PLIN1 Proteine)-attachment period in the cow.
CSF2 affect embryonic development and enhance embryo competence for posttransfer survival.
These impaired macrophage functions in leukemic mice were significantly corrected by IL-3 (zeige IL-3 Proteine) and GM-CSF treatment indicating the therapeutic benefit of these two cytokines in leukemia.
Both IL-6 (zeige IL6 Proteine) protein production and transcript levels were downregulated by RA in respiratory tract epithelial cells (LETs) , but upregulated in macrophages (MACs). RA also increased transcript levels of MCP-1 (zeige CPT1B Proteine), GMCSF, and IL-10 (zeige IL10 Proteine) in MACs, but not in LETs. Conversely, when LETs, but not MACs, were exposed to RA
T-GM-CSF and -IL-3 (zeige IL-3 Proteine) significantly, and reciprocally, blunted receptor binding and myeloid progenitor cell proliferation activity of both FL-GM-CSF and -IL-3 (zeige IL-3 Proteine) in vitro and in vivo
Results indicate GM-CSF as both a key contributor to the pathogenesis of MI and a potential therapeutic target.
GM-CSF is required for the normal balance of leukocyte subsets, including granulocytes, B cells, and naive vs. effector T cells. There was an approximately 3-fold increase in the percentages of granulocytes in Csf2-/- PBMCs. The presence of maximal experimental autoimmune encephalomyelitis in the complete absence of GM-CSF revealed that GM-CSF is not an obligate effector molecule in all forms of EAE.
chemerin (zeige RARRES2 Proteine) inhibited nuclear factor-kappaB activation and the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (zeige IL2 Proteine) (IL-6 (zeige IL6 Proteine)) by tumor cells and tumor-associated endothelial cell, respectively, via its receptors, and consequently, MDSC induction was impaired, leading to restoration of antitumor T-cell response and decreased tumor angiogenesis.
These findings describe a novel role for GM-CSF as an essential initiating cytokine in cardiac inflammation.
Data reviewed establish that any damage to brain tissue tends to cause an increase in G-CSF (zeige CSF3 Proteine) and/or GM-CSF (G(M)-CSF (zeige CSF1R Proteine)) synthesized by the brain. Glioblastoma cells themselves also synthesize G(M)-CSF (zeige CSF1R Proteine). G(M)-CSF (zeige CSF1R Proteine) synthesized by brain due to damage by a growing tumor and by the tumor itself stimulates bone marrow to shift hematopoiesis toward granulocytic lineages away from lymphocytic lineages.
Evi1 (zeige MECOM Proteine)(+)DA-3 cells modified to express an intracellular form of GM-CSF, acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF levels.
CSF2 stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (zeige MAPK1 Proteine)-dependent MTOR (zeige FRAP1 Proteine) signal transduction cascades.
Data indicate that differentially expressed IL-17 (zeige IL17A Proteine), IL-22 (zeige IL22 Proteine), and IL-23 (zeige IL23A Proteine) levels are associated with K-ras (zeige HRAS Proteine) in a stage-specific fashion along colorectal cancer progression and an association was established between mutant K-ras (zeige HRAS Proteine) and GM-CSF and IFN-gamma (zeige IFNG Proteine).
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.
granulocyte-macrophage colony-stimulating factor
, colony stimulating factor 2 (granulocyte-macrophage)
, colony-stimulating factor
, granulocyte-macrophage colony stimulating factor 2
, put. GM-CSF
, granulate-macrophage stimulating factor
, granulocyte-macrophage stimulation factor