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anti-Human ube3a Antikörper:
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Human Polyclonal ube3a Primary Antibody für IP, WB - ABIN153040
Jiang, Sahoo, Michaelis, Bercovich, Bressler, Kashork, Liu, Shaffer, Schroer, Stockton, Spielman, Stevenson, Beaudet: A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. in American journal of medical genetics. Part A 2004
Show all 8 Pubmed References
Human Monoclonal ube3a Primary Antibody für IF, WB - ABIN968525
Matsuura, Sutcliffe, Fang, Galjaard, Jiang, Benton, Rommens, Beaudet: De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. in Nature genetics 1997
Show all 2 Pubmed References
Human Polyclonal ube3a Primary Antibody für WB - ABIN153039
Sato, Stryker: Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a. in Proceedings of the National Academy of Sciences of the United States of America 2010
Human Monoclonal ube3a Primary Antibody für IF, IHC (p) - ABIN563326
Underbrink, Howie, Bedard, Koop, Galloway: E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. in Journal of virology 2008
Human Monoclonal ube3a Primary Antibody für IF, IHC (p) - ABIN2477024
Wolyniec, Shortt, de Stanchina, Levav-Cohen, Alsheich-Bartok, Louria-Hayon, Corneille, Kumar, Woods, Opat, Johnstone, Scott, Segal, Pandolfi, Fox, Strasser, Jiang, Lowe, Haupt, Haupt: E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis. in Blood 2012
our data demonstrates that E6AP facilitates ubiquitination and subsequent degradation of G-CSFR (zeige CSF3R Antikörper) leading to attenuation of its downstream signaling and inhibition of granulocytic differentiation.
Novel intragenic deletions within the UBE3A gene have been reported in two unrelated patients with Angelman syndrome.
Data suggest ordered binding of UBCH7 (zeige UBE2L3 Antikörper)-ubiquitin to E6AP Site 1 (for E6AP-Cys820/ubiquitin thioester formation) and E6AP Site 2 (for subsequent chain elongation); proximal indexation accounts for symmetric structure of E6AP, requirement for oligomerization in polyubiquitin (zeige UBB Antikörper) chain formation, and mechanistic rationale for Cys820-ubiquitin thioester as platform in chain assembly. (UBCH7 (zeige UBE2L3 Antikörper) = ubiquitin-conjugating enzyme UBCH7 (zeige UBE2L3 Antikörper))
E6AP (UBE3A) abundance is down-regulated in a proportion of NSCLC (non (zeige CDKN2A Antikörper)-small cell lung (zeige CDKN2B Antikörper)cancer) pati (zeige CDKN2A Antikörper)ents, and this (zeige CDKN2A Antikörper) correlates with low p16INK4a in tumors and worse overall survival.
study has broad implications for human disorders associated with UBE3A gain or loss of function and suggests that dysfunctional UBE3A might affect additional proteins and pathways that are sensitive to proteasome activity
We found that KD of E6AP attenuates cancer cell growth by promoting cellular senescence in vivo, which correlates with restoration of tumor suppression by PML (zeige PML Antikörper).
HCV core protein inhibits E6AP expression via DNA methylation to protect itself from ubiquitin-dependent proteasomal degradation and stimulate virus propagation.
E6AP suppresses breast cancer metastasis by regulating actin cytoskeleton remodeling through the control of ECT2 (zeige ECT2 Antikörper) and Rho GTPase (zeige RACGAP1 Antikörper) activity.
Dube3a is neither imprinted nor preferentially expressed from the maternal allele in fly neurons.
The ubiquitylation of beta-catenin (zeige CTNNB1 Antikörper) by E6AP was dependent on its E3 ubiquitin ligase (zeige MUL1 Antikörper) activity, but it was proteasome-independent and did not require HPV16-E6.
Encephalomyocarditis virus (EMCV) 3C protease accumulates to higher levels in EMCV-infected E6AP knockdown cells than in control cells, indicating a role for E6AP in in vivo 3C protease concentration regulation.
The expression of three tumor suppressor genes encoded in the INK4/ARF (zeige CDKN2A Antikörper) locus (p15(INK4b (zeige CDKN2B Antikörper)), p16(INK4a (zeige CDKN2A Antikörper)), and p19(ARF (zeige CDKN2A Antikörper))) was decreased in E6AP(-/-) embryo fibroblasts.
Maternal loss of Ube3a affects nociception via a central, but not peripheral mechanism.
Our findings suggest that UBE3A may act locally to regulate individual synapses while also mediating global, neuronwide influences through the regulation of gene transcription
treatment of topotecan, a brain-penetrating topoisomerase 1 (zeige TOP1 Antikörper) inhibitor, to HD transgenic mouse considerably improved its motor behavioural abnormalities. Finally, we show that topotecan treatment to HD mouse not only inhibits the expression of transgenic mutant huntingtin (zeige HTT Antikörper), but also at the same time induces the expression of Ube3a
We report that mice with maternally-inherited deletions of Ube3a that models Angelman syndrome show an increased social preference/interaction.
increasing UBE3A in the nucleus downregulates the glutamatergic synapse organizer Cbln1 (zeige CBLN1 Antikörper), which is needed for sociability in mice
Based on our findings, we propose that imprinting of UBE3A does not function to reduce the dosage of UBE3A in neurons but rather to regulate some other, as yet unknown, aspect of gene expression or protein function
the role of UBE3A is investigated in neurite contact guidance during neuronal development, is reported.
Results substantiate GABAergic Ube3a loss as the principal cause of circuit hyperexcitability in Angelman syndrome mice, lending insight into ictogenic mechanisms in AS.
Negative regulation of Tkv by Ube3a was conserved in mammalian cells. These results reveal a critical role for Ube3a in regulating NMJ synapse development by repressing BMP (zeige TGFb Antikörper) signaling. This study sheds new light onto the neuronal functions of UBE3A and provides novel perspectives for understanding the pathogenesis of UBE3A-associated disorders.
Data indicate that E3 ligase called ube3 (dube3a) is required for brain development as mutants have defective mushroom bodies.
Rpn10 is targeted for degradation by Ube3a.
In Drosophila melanogaster the human homologue ube3a regulates the actin cytoskeleton and neuronal homeostasis.
MeCP2 and E6AP play a role in the transcriptional control of common target gene expression.
Ube3a regulates serotonin and dopamine synthesis in the fly brain by increasing GTP cyclohydrolase I (zeige GCH1 Antikörper) activity.
dube3a null mutants appear normal externally, but display abnormal locomotive behavior and circadian rhythms, and defective long-term memory; overexpression in the nervous system caused locomotion defects, dependent on the ubiquitin ligase activity
Overexpression of dUBE3A decreased dendritic branching.
In the skeletal muscle of neonate pigs, both NECD (zeige NDN Antikörper) and SNRPN (zeige SNRPN Antikörper) were maternally imprinted, while UBE3A was not imprinted.
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
CTCL tumor antigen se37-2
, E6AP ubiquitin-protein ligase
, human papilloma virus E6-associated protein
, human papillomavirus E6-associated protein
, oncogenic protein-associated protein E6-AP
, renal carcinoma antigen NY-REN-54
, ubiquitin-protein ligase E3A
, ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)
, ubiquitin protein ligase E3A
, E6-AP ubiquitin protein ligase
, ubiquitin conjugating enzyme E3A
, drosophila angelman syndrome
, angelman syndrome
, ubiquitin-protein ligase E3A-like