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Isolated Hic-5(-/-);PyMT CAFs (zeige TBX1 ELISA Kits) were defective in stress fiber organization and exhibited reduced contractility. These cells also failed to efficiently deposit and organize the ECM (zeige MMRN1 ELISA Kits) in two and three dimensions. This, in turn, impacted three-dimensional MDA-MB-231 tumor cell migration behavior
Hic-5 regulates GR binding site selection by a novel mechanism, exploiting gene-specific requirements for chromatin remodeling enzymes to selectively influence DNA occupancy and gene regulation by a transcription factor.
As aging increased, more ARA55 were expressed in PZ stromal cells, leading to more sensitive androgen/androgen receptor (AR (zeige AR ELISA Kits)) signal pathway, then constituting a more feasible environment to cancer cells.
Hic-5 appears to enhance complex formation between MT1-MMP (zeige MMP14 ELISA Kits) and FAK (zeige PTK2 ELISA Kits) in activated endothelial cells, which likely coordinates matrix proteolysis and cell motility.
Hic-5 plays a central role in the positive feedback ROS (zeige ROS1 ELISA Kits)-JNK (zeige MAPK8 ELISA Kits) signaling cascade that regulates hepatocellular carcinoma progression.
Hic-5 influences the genomic occupancy of multiple steroid receptors and thereby blocks some aspects of hormonal regulation.
Endothelial Hic-5 plays an important role in the formation of microvilli-like structures and in the interaction between ECs and monocytes, leading to monocyte recruitment and subsequent development of atherosclerosis.
Studies in vitro and in vivo using TGF-beta1 (zeige TGFB1 ELISA Kits) and TGFB1I1 shRNA demonstrated that TGFB1I1 is required for TGF-beta (zeige TGFB1 ELISA Kits) stimulated EMT (zeige ITK ELISA Kits) that contributes to malignant progression of astrocytomas.
Hic-5 siRNA also suppressed TGF-beta2 (zeige TGFB2 ELISA Kits)-induced fibrogenic activity and dexamethasone-induced myocilin (zeige MYOC ELISA Kits) expression in HTM cells.
Hic5 coordinates AR signaling with adhesion and extracellular matrix contacts to regulate cell behavior in the tumor microenvironment.
Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 (zeige PAX6 ELISA Kits) and the LIM protein (zeige PDLIM1 ELISA Kits) complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation.
paxillin (zeige PXN ELISA Kits) and Hic-5 have both redundant and distinctive functions in invadosome formation.
Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis though reducing the TGF-beta (zeige TGFB1 ELISA Kits)/Smad2 (zeige SMAD2 ELISA Kits) signaling by upregulation of Smad7 (zeige SMAD7 ELISA Kits)
Hic-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice.
Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor (zeige NR3C1 ELISA Kits) genome occupancy in a gene-selective manner.
Hic-5 is expressed in B16-F1 murine melanoma cells.
identified Hic-5 as a novel and specific regulatory factor for thrombin (zeige F2 ELISA Kits)-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.
the HIC-5- and KLF4 (zeige KLF4 ELISA Kits)-dependent mechanism transactivates p21(Cip1 (zeige CDKN1A ELISA Kits)) in response to anchorage loss
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
transforming growth factor beta 1 induced transcript 1
, androgen receptor coactivator ARA55
, transforming growth factor beta-1-induced transcript 1 protein-like
, androgen receptor coactivator 55 kDa protein
, androgen receptor-associated protein of 55 kDa
, hydrogen peroxide-inducible clone 5 protein
, transforming growth factor beta-1-induced transcript 1 protein
, TGF beta-stimulated clone 5
, androgen receptor activator of 55 kDa