Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Rat (Rattus) Antikörper:
anti-Mouse (Murine) Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal SMARCA4 Primary Antibody für ChIP, ICC - ABIN4285245
Miyamoto, Pasque, Jullien, Gurdon: Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. in Genes & development 2011
Show all 4 Pubmed References
Human Polyclonal SMARCA4 Primary Antibody für WB - ABIN686122
Chen, Han, Wei, Zhang, Shi, Duan, Li, Zhou, Pu, Zhang, Kang: SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma. in Scientific reports 2015
Human Monoclonal SMARCA4 Primary Antibody für ICC, IF - ABIN2668499
Ohkawa, Harada, Nakamura, Yoshimura, Tachibana: Production of a rat monoclonal antibody against Brg1. in Hybridoma (2005) 2009
Human Monoclonal SMARCA4 Primary Antibody für ICC, IF - ABIN2668498
de la Serna, Ohkawa, Higashi, Dutta, Osias, Kommajosyula, Tachibana, Imbalzano: The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes. in The Journal of biological chemistry 2006
The vast majority of SCCOHT demonstrate genomic SMARCA4 loss with only rare co-occurring alterations. Data support a role for CGP in the diagnosis and management of SCCOHT and of other lesions with overlapping histological and clinical features, since identifying the former by genomic profile suggests benefit from an appropriate regimen and treatment decisions.
BRG1 can promote VEGF-A (zeige VEGFA Antikörper) expression and angiogenesis in colorectal cancer and BRG1 may be a novel drug target for the treatment of colorectal cancer.
The BRG1/SIRT1 (zeige SIRT1 Antikörper)/p53 (zeige TP53 Antikörper) signal axis is a novel mechanism of cell senescence in CRC (zeige CALR Antikörper).
BRG1 and SMARCAL1 (zeige SMARCAL1 Antikörper), members of the ATP-dependent chromatin remodelling family, are shown to co-regulate the transcription of DROSHA (zeige DROSHA Antikörper), DGCR8 (zeige DGCR8 Antikörper), and DICER (zeige DICER1 Antikörper) in response to double-strand DNA breaks.
BRG1 was significantly increased in hepatocellular carcinoma. Overexpression of BRG1 increases cell growth and invasiveness in HCC (zeige FAM126A Antikörper).
Case Report: SMARCA4 nonsense/frameshift mutations responsible for concomitant Coffin-Siris syndrome, microphthalmia and small-cell carcinoma of the ovary hypercalcaemic type.
i-motif structures in long cytosine-rich sequences found upstream of the promoter region of the SMARCA4 gene
Brg1 coordinates a genetic and epigenetic network that regulates the transcriptional program underlying the Shh (zeige SHH Antikörper)-type medulloblastoma development.
whole-genome transcriptome analysis revealed that BRG1 controls the expression of key elements of oncogenic pathways such as PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) and BCL2 (zeige BCL2 Antikörper), which offers a promising new combination therapy for high-risk Neuroblastoma (zeige ARHGEF16 Antikörper) (NB).
A breakdown in a BRCA/FANCD2 (zeige FANCD2 Antikörper)/BRG1/SNF (zeige SNRPA Antikörper)-DeltaNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells may contribute to sporadic breast cancer development.
BRG1 is a SOX10 (zeige SOX10 Antikörper) co-activator, required to establish the melanocyte lineage and promote expression of genes important for melanocyte function.
n keratinocytes, the promoter-enhancer anchoring regions in the gene-rich transcriptionally active TADs are enriched for the binding of chromatin architectural proteins CTCF (zeige CTCF Antikörper), Rad21 (zeige RAD21 Antikörper) and chromatin remodeler Brg1. In contrast to gene-rich TADs, gene-poor TADs show preferential spatial contacts with each other, do not contain active enhancers and show decreased binding of CTCF (zeige CTCF Antikörper), Rad21 (zeige RAD21 Antikörper) and Brg1 in keratinocytes
Data demonstrate that Brg1 plays an essential role in development and homeostasis, including morphogenesis, stem cell differentiation and cell survival in the duodenum.
Point mutations in SMARCA4 (also known as BRG1) mapping to the ATPase (zeige DNAH8 Antikörper) domain cause loss of direct binding between BAF (zeige BANF1 Antikörper) and PRC1 (zeige PRC1 Antikörper).
BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.
RB is necessary for the recruitment of the BRG1 ATPase (zeige DNAH8 Antikörper) to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination
Cdx (zeige CDX1 Antikörper) members interact with the SWI (zeige SMARCA1 Antikörper)-SNF (zeige SNRPA Antikörper) complex and make direct contact with Brg1, a catalytic member of SWI (zeige SMARCA1 Antikörper)-SNF (zeige SNRPA Antikörper). Both Cdx2 (zeige CDX2 Antikörper) and Brg1 co-occupy a number of Cdx (zeige CDX1 Antikörper) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 (zeige CDX2 Antikörper) and Brg1 occupancy occurs coincident with chromatin remodeling at some of these loci.
BRG1/BRM (zeige SMARCA2 Antikörper) and c-MYC (zeige MYC Antikörper) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (zeige RAB1A Antikörper) in cancer.
Results provide insights into the mechanisms by which Brg1 functions, which is in part via the p53 (zeige TP53 Antikörper) program, to constrain gene expression and facilitate rapid embryonic growth.
Brg1 promotes neurogenic radial glial progenitor cell specification but is dispensable for neuronal differentiation
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4
, transcription activator BRG1-like
, ATP-dependent helicase SMARCA4
, BRG1-associated factor 190A
, BRM/SWI2-related gene 1
, SNF2-like 4
, brahma protein-like 1
, global transcription activator homologous sequence
, homeotic gene regulator
, mitotic growth and transcription activator
, nuclear protein GRB1
, protein BRG-1
, protein brahma homolog 1
, sucrose nonfermenting-like 4
, transcription activator BRG1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
, SWI/SNF related transcriptional activator
, WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4