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Endoplasmic reticulum resident chaperone GRP78 (zeige HSPA5 ELISA Kits), mitochondrial protein (zeige COX6B2 ELISA Kits) Prohibitin and heterogeneous nuclear ribonucleoprotein (zeige PCBP2 ELISA Kits) hnRNPC (zeige HNRNPC ELISA Kits) (C1/C2) have been shown to interact with viral RNA. Hence it is proposed that these are the principle candidates governing endoplasmic reticulum stress-induced apoptosis in JEV infection.
PHB1 down regulation suppresses liver cancer and bile duct cancer tumorigenesis.
PHB has an unexpected nuclear role in human embryonic stem cells that is required for self-renewal and that it acts with HIRA (zeige HIRA ELISA Kits) in chromatin organization to link epigenetic organization to a metabolic circuit.
results demonstrate that the H19 (zeige NCKAP1 ELISA Kits)-Igf2 axis is negatively regulated by CTCF (zeige CTCF ELISA Kits)-PHB1 cooperation and that H19 (zeige NCKAP1 ELISA Kits) is involved in modulating the growth-suppressive effect of PHB1 in the liver.
PHB promotes AR activation in ER-positive breast cancer.
High PHB expression is associated with breast cancer.
Data shows that PHB protein was overexpressed in gallbladder cancer tissues and significantly associated with histological grade, tumor stage and perineural invasion.
The present review focus is on recent developments in prohibitin (PHB) research in relation to ovarian granulosa cells physiological functions. [review]
We propose a model whereby in analogy to previous findings (e.g., the RAS-RAF (zeige RAF1 ELISA Kits) signalling pathway), PHB can act as a signalling scaffold protein (zeige HOMER1 ELISA Kits) to assist in KDELR-dependent Src (zeige SRC ELISA Kits) activation
a majority of patients with IgG4-related disease have antibodies against prohibitin.
obesity-associated hyperinsulinemia promotes tumor development by facilitating dormant mutant to manifest and reveals a sex-dimorphic role of PHB in adipose-immune interaction or immunometabolism.
Study shows that PHB is highly expressed in white adipose tissue and liver which expression is regulated by estrogen.
This study identifies a novel signaling pathway composed of miR (zeige MLXIP ELISA Kits)-361 and PHB1 that regulates mitochondrial fission program and apoptosis.
Both c-Myc (zeige MYC ELISA Kits) and PHB1 directly interact with Nrf2 (zeige NFE2L2 ELISA Kits) but c-Myc (zeige MYC ELISA Kits) lowers Nrf2 (zeige NFE2L2 ELISA Kits) binding to antioxidant response elemens while PHB1 enhances it.
A role for PHB in GnRH-induced cell death in mature gonadotropes, which is crucial for the normal development and function of the reproductive axis.
Data indicate that phosphorylation of Tyr114 and Tyr259 of prohibitin (PHB) is critical for the association of PHB with FcRI (zeige FCGR1A ELISA Kits) and Syk (zeige SYK ELISA Kits).
maintaining expression of intestinal epithelial cell prohibitin reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 (zeige HMOX1 ELISA Kits) and NQO-1 (zeige NQO1 ELISA Kits) via a mechanism independent of Nfe2 (zeige NFE2 ELISA Kits)
Phb1/2 and the CD86 (zeige CD86 ELISA Kits) cytoplasmic domain cooperate to mediate CD86 (zeige CD86 ELISA Kits) signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IgG1.
Findings suggest that PHB protects against colitis-associated cancer by modulating p53 (zeige TP53 ELISA Kits)- and STAT3 (zeige STAT3 ELISA Kits)-mediated apoptosis.
Data show that protein-tyrosine phosphatase (zeige ACP1 ELISA Kits) PRP4A3 (prl3 (zeige PTP4A3 ELISA Kits)) and van gogh like1 (vangl1 (zeige Vangl1 ELISA Kits)) are Necessary Components in prohibitin1 (phb1) dependent neural crest specification.
Xphb1 represses E2F1 (zeige E2F1 ELISA Kits) activity.
Prohibitin is involved in oxidative stress signaling in the retina and retinal pigment epithelium.
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
, prohibitin protein Wph
, B-cell receptor-associated protein 32