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NCOA4 acts as a regulator of DNA replication origins that helps prevent inappropriate DNA synthesis and replication stress.
Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.
Studies indicate nuclear receptor coactivator 4 (NcoA4) as a coactivator for a variety of nuclear receptors.
provide a new mechanism for selective autophagy of ferritin (zeige FTL Proteine) and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo
RET (zeige RET Proteine)/PTC3 gene rearrangements are the most prevalent form of rearrangements in papillary thyroid carcinomas of Chennai population.
identification of NCOA4 as a selective cargo receptor for autophagic turnover of ferritin (zeige FTL Proteine) (ferritinophagy), which is critical for iron homeostasis, and provides a resource for further dissection of autophagosomal cargo-receptor connectivity
mechanism dissection shows that KLK2 (zeige KLK2 Proteine) may cooperate with the AR coregulator, ARA70, to enhance AR transactivation that may result in alteration of prostate cancer formation
Data indicate that the increase in prostate cancer (PC) risk associated with rs10993994:C>T is likely mediated by the variant's effect of MSMB (zeige MSMB Proteine)-encoded protein PSP94 (zeige MSMB Proteine) expression; however, this effect does not extend to NCOA4 in the data.
Computational network analysis reveals that the MSMB (zeige MSMB Proteine) gene is functionally connected to NCOA4 and the androgen receptor (zeige AR Proteine) signaling pathway. The data provide an example of how GWAS-associated variants may have multiple genetic and epigenetic effects
Suppression of MSMB (zeige MSMB Proteine) expression or NCOA4 overexpression promotes anchorage-independent growth of prostate epithelial cells.
These studies demonstrate the importance of ferritin (zeige FTL Proteine) for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 (zeige PCBP1 Proteine) and NCOA4 in mediating iron flux through ferritin (zeige FTL Proteine).
NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo.
Results demonstrate ubiquitous NcoA4 expression throughout development and suggest that this coactivator may play a role in modulating nuclear receptor activity, particularly that of the aryl hydrocarbon receptor (zeige AHR Proteine), during development.
Data suggest that myostatin (zeige MSTN Proteine) decreases the activity of androgen receptors (AR) by down-regulating the expression of ARA70, a known stimulating co-factor of AR
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
nuclear receptor coactivator 4
, Nuclear receptor coactivator 4
, 70 kDa AR-activator
, 70 kDa androgen receptor coactivator
, RET-activating gene ELE1
, androgen receptor-associated protein of 70 kDa
, ret fused