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Human NCOA3 ELISA Kit für Sandwich ELISA - ABIN420407
Zhou, Wei, Chen, Dong, Lai, Fang, Jiang, Lu, Zhou, Xie, Luo, Chen: Identification and validation of AIB1 and EIF5A2 for noninvasive detection of bladder cancer in urine samples. in Oncotarget 2016
Data indicate that phosphorylated cortactin recruits Vav2 to activate Rac3 and promote invadopodial maturation in invasive breast cancer cells.
Estrogen receptor (zeige ESR1 ELISA Kits) recruits steroid receptor coactivator (zeige SRA1 ELISA Kits)-3 primary coactivator and secondary coactivators, p300/CBP (zeige CREBBP ELISA Kits) and CARM1 (zeige CARM1 ELISA Kits) to regulate genetic transcription.
we identify a positive feedback regulatory loop consisting of XBP1 (zeige XBP1 ELISA Kits) and NCOA3 that maintains high levels of NCOA3 and XBP1 (zeige XBP1 ELISA Kits) expression in breast cancer tissues.
loss of miR-17 and miR (zeige MLXIP ELISA Kits)-20b enhanced breast cancer resistance to taxol by upregulating NCOA3 levels.
Data (including data from studies of hydrogen-deuterium exchange coupled to mass spectrometry in presence of denaturants) suggest that, for peptide fragments of human ACTR and mouse Crebbp (zeige CREBBP ELISA Kits) representing disordered interaction domains, exchange rates are changed dramatically by high concentrations of denaturants guanidinium chloride or urea. (ACTR = activator of thyroid and retinoid receptor; Crebbp (zeige CREBBP ELISA Kits) = CREB binding protein (zeige CREBBP ELISA Kits))
Data suggest that steroid receptor (zeige ESR2 ELISA Kits) coactivators (NCOA1 (zeige NCOA1 ELISA Kits), NCOA2 (zeige NCOA2 ELISA Kits), NCOA3) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (zeige ESR2 ELISA Kits) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
Here, we reported the novel finding that depletion of SRC-3 enhanced sensitivity of breast and lung cancer cells to HDAC (zeige HDAC3 ELISA Kits) inhibitors (SAHA and romidepsin). In contrast, overexpression of SRC-3 decreased SAHA-induced cancer cell apoptosis. Furthermore, we found that SRC-3 inhibitor bufalin increased cancer cell apoptosis induced by HDAC (zeige HDAC3 ELISA Kits) inhibitors. The combination of bufalin and SAHA was particular efficient in attenuating
Altered expression of AIB1 may play a role in adenomyosis development and treatment outcome with levonorgestrel-releasing intrauterine system.
The oncogenic transcription factor AIB1 has a novel role in the regulation of polyribosome recruitment and formation of the translational complex. Combinatorial therapies targeting IGF signaling and mRNA translation in AIB1 expressing breast cancers may have clinical benefit and warrants further investigation
Total SRC3 is selectively found at enhancer regions.
findings show that SRC-3 contributes to host defense against enteric bacteria, at least in part via upregulating CXCL2 (zeige CXCL2 ELISA Kits) expression to recruit neutrophils
Findings indicate that the Gata6 (zeige GATA6 ELISA Kits) promoter is activated by Esrrb (zeige ESRRB ELISA Kits) in association with Ncoa3, and Dax1 (zeige NR0B1 ELISA Kits) inhibited activities of Esrrb (zeige ESRRB ELISA Kits) and Ncoa3, resulting maintenance of the undifferentiated status of embryonic stem (ES) cells.
SRC-1 (zeige NCOA1 ELISA Kits)/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC (zeige SLC12A3 ELISA Kits)-like abnormalities in the hearts of newborn and adult mice.
AIB1 promotes gastric cancer cell proliferation, survival and invasiveness through modulating major signaling pathways such as ErbB (zeige EGFR ELISA Kits) and Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) pathways. Findings suggest that AIB1 plays an important role in the pathogenesis of gastric cancer.
SRC-3 is a target for inhibiting aggressive prostate cancer containing neuroendocrine tumor cells.
Impaired hematopoiesis and delayed thrombopoietic recovery following sublethal irradiation in SRC3 knockout mice.
The p/CIP gene regulatory network identifies various feed-forward modules including one in which p/CIP activates members of the extended pluripotency network, demonstrating that p/CIP is a component of this extended network.
Loss of SRC3 also shows sex differences in anxiety and exploratory behaviors.
IRS1 (zeige IRS1 ELISA Kits) levels are significantly increased in mouse cell lines representing fat and muscle lineages with p/CIP and SRC-1 (zeige NCOA1 ELISA Kits) deletions and in white adipose tissue and skeletal muscle of knockout mice.
Data show that knockdown of nuclear receptor coactivator 3 (Ncoa3) not only compromises the expression of pluripotency markers but also impairs in vitro and in vivo differentiation potential of embryonic stem cells.
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.
nuclear receptor coactivator 3
, CBP-interacting protein
, amplified in breast cancer 1 protein
, class E basic helix-loop-helix protein 42
, receptor-associated coactivator 3
, steroid receptor coactivator protein 3
, thyroid hormone receptor activator molecule 1
, steroid receptor coactivator 3
, amplified in breast cancer-1 protein homolog
, retinoid X receptor-interacting coactivator xSRC-3