anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Antikörper

Auf www.antikoerper-online.de finden Sie aktuell 35 Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Antikörper von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Kits (10) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 47 Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Produkte verfügbar.
Synonyme:
AAD10, ALR, BC032281, BC058659, C430014K11Rik, CAGL114, GSTO1, HRX2, im:7157663, KABUK1, KMS, KMT2B, MLL1B, Mll2, Mll4, TNRC21, TRX2, WBP7
Alle Antikörper anzeigen Gen GeneID UniProt
MLL2 27100 Q63042
MLL2 9757 Q9UMN6
MLL2 381022  

Meistgesuchte Reaktivitäten zu anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Antikörper

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Human Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Interaktionspartner

  1. Three of four cases of histiocytic sarcoma had alterations in the KMT2D gene.

  2. Study shows the contribution of MLL2's methyltransferase and CXXC domain in the trimethylation of H3K4 in embryonic stem cells and find that while it trimethylates H3K4 at both bivalent gene promoters and non-TSS (zeige RPL38 Antikörper) elements, it regulates transcription at a limited number of genes including those required for primordial germ cell specification.

  3. KMT2D Mutation is associated with esophageal squamous cell carcinoma.

  4. The crucial role of KMT2B in the physiological control of voluntary movement.

  5. MLL1 and MLL2 collaborate to regulate gene expression and leukemia maintenance not through redundancy, but through distinct pathways.

  6. Our findings provide evidence that CHARGE and Kabuki syndromes result from dysregulatrion of CHD7 (zeige CHD7 Antikörper) and KMT2D genes involved embryonal development that are expressed in a tissue-specific manner.

  7. we demonstrate that low KMT2C and KMT2D expression in biopsies defines better outcome groups in pancreatic ductal adenocarcinoma

  8. MLL4 mutation along with BRCA1 mutation confers chemoresistance in breast cancer.

  9. Pathogenic variants in KMT2D resulting in protein truncation in 43% (6/14; of which 3 are novel) of all cases were detected, while analysis of KDM6A (zeige KDM6A Antikörper) was negative. MLPA analysis was negative in all instances.

  10. Results show that KMT2B interacts with ERalpha (zeige ESR1 Antikörper) to bind the ERalpha (zeige ESR1 Antikörper)-binding sites of IL-20 (zeige IL20 Antikörper) and other ERalpha (zeige ESR1 Antikörper) target genes with H3K4 modifications suggesting an important role for KMT2B in the epigenetic transcriptional regulation of cytokine IL-20 (zeige IL20 Antikörper), and other ERalpha (zeige ESR1 Antikörper)-responsive genes, in breast cancer cells.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Interaktionspartner

  1. UTX (zeige KDM6A Antikörper)-MLL4 (zeige MLL4 Antikörper)-p300 (zeige NOTCH1 Antikörper) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.

  2. MLL4 (zeige MLL4 Antikörper) deficiency compromised the development of regulatory T cells (Treg cells) and resulted in a substantial decrease in monomethylated H3K4 (H3K4me1) and chromatin interaction at putative gene enhancers, a considerable portion of which were not direct targets of MLL4 (zeige MLL4 Antikörper) but were enhancers that interacted with MLL4 (zeige MLL4 Antikörper)-bound sites.

  3. Study shows the contribution of MLL2 (zeige MLL4 Antikörper)'s methyltransferase and CXXC domain in the trimethylation of H3K4 in embryonic stem cells and find that while it trimethylates H3K4 at both bivalent gene promoters and non-TSS (zeige RPL38 Antikörper) elements, it regulates transcription at a limited number of genes including those required for primordial germ cell specification.

  4. While H3K4me1 partially supports H3K27ac at active enhancers, it is largely dispensable for transcription. By contrast, Mll3/4 proteins themselves are required for enhancer Pol II loading, eRNA synthesis, and gene expression.

  5. Data from MLL4/KMT2D enzyme-dead knockin ES cells and mice indicate that the enzymatic activity of H3K4 methyltransferase MLL4 (zeige MLL4 Antikörper) is required for its protein stability.

  6. Although enhancer priming by H3K4me1/2 methyltransferase MLL4/KMT2D is dispensable for cell-identity maintenance, it controls cell fate transition by orchestrating p300 (zeige NOTCH1 Antikörper)-mediated enhancer activation

  7. KMT2D is essential for regulating cardiac gene expression during heart development primarily via H3K4 di-methylation

  8. MLL2 interacts with RNA polymerase II (RNAPII) and RECQL5, and, although MLL2 mutated cells have normal overall H3K4me levels in genes, nucleosomes in the immediate vicinity of RNAPII are hypomethylated.

  9. MLL4 (KMT2D) is a major H3K4 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C) in mouse and human cells. MLL4 is enriched on enhancers and is required for enhancer activation, cell-type-specific gene expression and cell differentiation.

  10. Both MLL3 and MLL4 (zeige MLL4 Antikörper) complexes act as major epigenetic regulators of diverse metabolic processes (including circadian control of bile acid homeostasis).

Pig (Porcine) Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Interaktionspartner

  1. MLL2 is essential for porcine embryo development by the regulation of methylation of H3K4 in vitro.

Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome.

Alternative names and synonyms associated with Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2)

  • lysine (K)-specific methyltransferase 2D (kmt2d) Antikörper
  • glutathione S-transferase omega-1-like (LOC785216) Antikörper
  • growth factor, augmenter of liver regeneration (Gfer) Antikörper
  • lysine (K)-specific methyltransferase 2B (KMT2B) Antikörper
  • lysine (K)-specific methyltransferase 2D (Kmt2d) Antikörper
  • lysine (K)-specific methyltransferase 2D (KMT2D) Antikörper
  • myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2) Antikörper
  • myeloid/lymphoid or mixed-lineage leukemia 2-like (Mll2l) Antikörper
  • AAD10 Antikörper
  • ALR Antikörper
  • BC032281 Antikörper
  • BC058659 Antikörper
  • C430014K11Rik Antikörper
  • CAGL114 Antikörper
  • GSTO1 Antikörper
  • HRX2 Antikörper
  • im:7157663 Antikörper
  • KABUK1 Antikörper
  • KMS Antikörper
  • KMT2B Antikörper
  • MLL1B Antikörper
  • Mll2 Antikörper
  • Mll4 Antikörper
  • TNRC21 Antikörper
  • TRX2 Antikörper
  • WBP7 Antikörper

Bezeichner auf Proteinebene für MLL2

myeloid/lymphoid or mixed-lineage leukemia 2 , glutathione S-transferase omega 1 , FAD-linked sulfhydryl oxidase ALR , augmenter of liver regeneration , growth factor, erv1 homolog , growth factor, erv1-like (augmenter of liver regeneration) , KMT2D , WBP-7 , WW domain binding protein 7 , WW domain-binding protein 7 , histone-lysine N-methyltransferase 2B , histone-lysine N-methyltransferase MLL4 , lysine N-methyltransferase 2B , lysine N-methyltransferase 2D , mixed lineage leukemia gene homolog 2 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4 , myeloid/lymphoid or mixed-lineage leukemia 4 , myeloid/lymphoid or mixed-lineage leukemia protein 4 , trithorax homolog 2 , trithorax homologue 2 , ALL1-related protein , histone-lysine N-methyltransferase 2D , histone-lysine N-methyltransferase MLL2 , myeloid/lymphoid or mixed-lineage leukemia protein 2 , Kabuki make-up syndrome , Kabuki mental retardation syndrome , trinucleotide repeat containing 21

GENE ID SPEZIES
100158249 Danio rerio
785216 Bos taurus
27100 Rattus norvegicus
9757 Homo sapiens
381022 Mus musculus
8085 Homo sapiens
506805 Bos taurus
100512962 Sus scrofa
486558 Canis lupus familiaris
425846 Gallus gallus
362996 Rattus norvegicus
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