anti-MED12 (MED12) Antikörper

Auf www.antikoerper-online.de finden Sie aktuell 52 Mediator Complex Subunit 12 (MED12) Antikörper von 12 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MED12 Kits (11) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 67 MED12 Produkte verfügbar.
Synonyme:
230kDa, ARC240, CAGH45, FGS1, HOPA, MED12S, Mopa, OHDOX, OKS, OPA-1, OPA1, Tnrc11, Trap230
Alle Antikörper anzeigen Gen GeneID UniProt
MED12 9968 Q93074
MED12 679693  
MED12 59024 A2AGH6

Meistgesuchte Reaktivitäten zu anti-MED12 (MED12) Antikörper

anti-Human MED12 Antikörper:

anti-Rat (Rattus) MED12 Antikörper:

anti-Mouse (Murine) MED12 Antikörper:

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Weitere Antikörper gegen MED12 Interaktionspartner

Human Mediator Complex Subunit 12 (MED12) Interaktionspartner

  1. Current study findings may help to narrow down the number of MED12 mutations to be screened for mediator complex dysfunction associated genetic diseases. This study supports computational methods as a primary filter to verify the plausible impact of pathogenic mutations based on the perspective of evolution, expression and phenotype of proteins.

  2. MED12-mutated adenosarcoma-like tumours might represent a distinct entity that requires more studies for its identification. MED12 exon 2 mutations seemed to have no significant role in other uncommon gynaecological mesenchymal tumours.

  3. role in the regulation of uterine fibroid cell proliferation through the modulation of Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper), cell cycle-associated, and fibrosis-associated protein expression

  4. Somatic MED12 mutations and biallelic FH inactivation are mutually exclusive in both HLRCC (zeige FH Antikörper) syndrome-associated and sporadic uterine leiomyomas. The great majority of HLRCC (zeige FH Antikörper) patients' uterine leiomyomas are caused by FH inactivation, but incidental tumours driven by somatic MED12 mutations also occur.

  5. 4.6% of leiomyosarcomas harbored MED12 exon 2 mutations, but the relevance of this association with molecular pathogenesis of leiomyosarcoma remains unknown.

  6. The high frequency and similar patterns of MED12 mutations in fibroadenomas and various grades of phyllodes tumours implies that the MED12 mutation is a common and early pathological event in these fibroepithelial tumours.

  7. Positive associations observed between MED12 and ERalpha (zeige ESR1 Antikörper), ERbeta (zeige ESR2 Antikörper) immunohistochemical expression suggest a biological interplay between the proteins.

  8. increased MED12 exon 2 mutation frequency in the multiple Uterine Leiomyomas was not accompanied by significant alterations in the spectrum of mutation categories

  9. Patients with malignant PTs (zeige PTS Antikörper) that harbored MED12 mutations demonstrated improved disease-free survival (DFS (zeige FST Antikörper)) compared with those without MED12 mutation

  10. MED12 mutations are associated with fibroid pathogenesis in a series of 103 uterine leiomyomas samples

Zebrafish Mediator Complex Subunit 12 (MED12) Interaktionspartner

  1. med12 mutants exhibit multiple defects in the development of the epithalamus, including failure of parapineal specification and disruption of cell differentiation and/or maintenance of specific cell types in the pineal organ and the habenula.

  2. The kto/med12 mutation results in specific defects of boundary cell formation in the zebrafish hindbrain

  3. critical targets of TRAP230 function may include proteins important for cell mobility, cell sorting, and tissue assembly

  4. A critical function of the Trap230 subunit is shown for Sox9 (zeige SOX9 Antikörper) as a coactivator; Trap230 also participates in Sox9 (zeige SOX9 Antikörper)-independent transcriptional regulation.

  5. reveal a regulatory role of motionless/Med12 in vertebrate neuronal development

  6. Med12 modulates the ability of Casanova/Sox32 to induce sox17 expression in endodermal development.

Mouse (Murine) Mediator Complex Subunit 12 (MED12) Interaktionspartner

  1. Study provide evidence that Med12 regulates neural stem cell gene expression programs linked to adhesion and cell cycle progression but suppresses its adhesion by repressing the expression of cell adhesion molecules.

  2. alterations in MED12-dependent enhancer regulation may control both physiological and malignant hematopoiesis.

  3. The data reveal how the interplay between PRC1 (zeige PRC1 Antikörper), ncRNA and Mediator complexes controls pluripotency and cellular differentiation.

  4. Med1 and Med12, two subunits of the mediator complex implicated in transcription initiation and long-range enhancer/promoter loop formation, are dynamically recruited to the IgH locus enhancers.

  5. leiomyomatous, Med12 c.131G>A variant-expressing uteri developed chromosomal rearrangements.

  6. this work points to Med12 being an essential coregulator of transcription factors controlling neural tube closure.

  7. show that in Med12 hypomorphic embryos, the Wnt (zeige WNT2 Antikörper)/planar cell polarity pathway is disrupted and that canonical Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling is impaired.

  8. Nanog (zeige NANOG Antikörper) and Med12 function in concert to regulate Nanog (zeige NANOG Antikörper) target genes and identify a novel role for Med12 in embryonic stem cell regulation.

MED12 Antigen-Profil

Beschreibung des Gens

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.

Alternative names and synonyms associated with MED12

  • mediator complex subunit 12 (MED12) Antikörper
  • mediator complex subunit 12 (Med12) Antikörper
  • mediator of RNA polymerase II transcription, subunit 12 homolog (med12) Antikörper
  • mediator of RNA polymerase II transcription, subunit 12 homolog (yeast) (Med12) Antikörper
  • 230kDa Antikörper
  • ARC240 Antikörper
  • CAGH45 Antikörper
  • FGS1 Antikörper
  • HOPA Antikörper
  • MED12S Antikörper
  • Mopa Antikörper
  • OHDOX Antikörper
  • OKS Antikörper
  • OPA-1 Antikörper
  • OPA1 Antikörper
  • Tnrc11 Antikörper
  • Trap230 Antikörper

Bezeichner auf Proteinebene für MED12

mediator of RNA polymerase II transcription, subunit 12 homolog , CAG repeat protein 45 , OPA-containing protein , activator-recruited cofactor 240 kDa component , human opposite paired , mediator of RNA polymerase II transcription subunit 12 , putative mediator subunit 12 , thyroid hormone receptor-associated protein complex 230 kDa component , thyroid hormone receptor-associated protein, 230 kDa subunit , trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit) , trinucleotide repeat-containing gene 11 protein , trinucleotide repeat containing 11 , kohtalo , kto , mediator complex subunit 12 , mot_m807 , motionless , protein kohtalo , protein motionless , shiri , shr , thyroid hormone receptor-associated protein 230 , thyroid hormone receptor-associated protein complex component TRAP230 , trap230 , OPA-containing protein 1 , trinucleotide repeat containing 11 (THR-associated protein)

GENE ID SPEZIES
480952 Canis lupus familiaris
9968 Homo sapiens
679693 Rattus norvegicus
449626 Pan troglodytes
566632 Danio rerio
59024 Mus musculus
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