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MLL3 binding was dependent on FOXA1, indicating that FOXA1 recruits MLL3 to chromatin. MLL3 silencing decreased H3K4me1 at enhancer elements but had no appreciable impact on H3K4me3 at enhancer elements. We propose a mechanism whereby the pioneer factor FOXA1 recruits the chromatin modifier MLL3 to facilitate the deposition of H3K4me1 histone marks, subsequently demarcating active enhancer elements
FoxA1 discriminates between medullary thyroid carcinoma and tumors of follicular derivation with sensitivity and specificity greater than calcitonin (zeige CALCA ELISA Kits) and carcinoembryonic antigen (zeige CEACAM5 ELISA Kits).
FOXA1 loss may play a significant role in enabling prostate cancer progression to neuroendocrine prostate cancer, whereas IL-8 (zeige IL8 ELISA Kits) and MAPK/ERK (zeige MAPK1 ELISA Kits) pathways may be promising targets for therapeutic intervention.
Low FOXA1 expression is associated with breast cancer invasion and metastasis.
the distinct mechanisms by which GATA2 (zeige GATA2 ELISA Kits) and FOXA1 regulate AR cistrome and suggest that FOXA1 acts upstream of GATA2 (zeige GATA2 ELISA Kits) and AR in determining hormone-dependent gene expression in prostate cancer.
Study implicates enhancer reprogramming, FOXA1 upregulation, and a retrograde developmental transition in pancreatic ductal adenocarcinoma metastasis.
Studies indicate that microRNA miR (zeige MLXIP ELISA Kits)-212 exerts its inhibitory effect on hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) by inhibiting forkhead transcription factor FOXA1 expression.
FOXA1 is expressed by basal cells of squamous epithelium, pre-invasion lesions of the uterine cervix and the head/neck and almost half invasive cervical and head/neck carcinomas, supporting its possible implication in HPV associated carcinomas.
CREB1 (zeige CREB1 ELISA Kits)/FoxA1 signaling is a targetable driver of prostate cancer progression and serves as a biomarker of poor clinical outcomes.
miR (zeige MLXIP ELISA Kits)-93 may promote the process of epithelial-mesenchymal transition in endometrial carcinoma cells by targeting FOXA1.
this model system will facilitate further in vivo functional studies of Foxa1 or other factors in mammary gland development and tumor formation and progression
Loss of Interdependent Binding by the FoxO1 (zeige FOXO1 ELISA Kits) and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin (zeige INS ELISA Kits)-sensitive Genes.
FoxA1, FoxA2 (zeige FOXA2 ELISA Kits), and LIPG (zeige LIPG ELISA Kits) control the uptake of extracellular lipids for breast cancer growth.
genome-wide binding sites of the forkhead/winged helix transcription factor (zeige FOXP2 ELISA Kits) Foxa1, which functions redundantly with Foxa2 (zeige FOXA2 ELISA Kits) to regulate the differentiation of midbrain dopamine neurons, were characterized.
Disruption of Shp (zeige LAMC1 ELISA Kits) in mice alters timing of expression of genes that regulate homocysteine metabolism and the liver responses to ethanol and homocysteine. SHP (zeige LAMC1 ELISA Kits) inhibits the transcriptional activation of Bhmt (zeige BHMT ELISA Kits) and cystathionine gamma-lyase (zeige CTH ELISA Kits) by FOXA1.
ChIP-exonuclease of the ER pioneer factor FoxA1 identifies protected DNA with a predictable 8 bp overhang from the Forkhead motif, which authors term mesas; showed that mesas occur in multiple cellular contexts and exist as single or overlapping motifs.
TIP30 (zeige HTATIP2 ELISA Kits) is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage via FoxA1.
Mechanistically, JARID1B was required for GATA3 (zeige GATA3 ELISA Kits) recruitment to the Foxa1 promoter to activate Foxa1 expression.
Foxa1 recruited Grg3 to the Nanog (zeige NANOG ELISA Kits) promoter -2kb upstream region and switched the promoter to an inactive chromatin status represented by typical modifications in histone H3 (zeige HIST3H3 ELISA Kits).
Results indicate Foxa1 expression is required for the maintenance of prostatic cellular differentiation.
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
forkhead box A1
, forkhead box protein A4
, HNF-3 alpha
, HNF3 alpha
, forkhead box protein A1
, forkhead transcription factor FoxA1
, forkhead homolog
, hepatocyte nuclear factor 3-alpha-like
, fork head domain protein 7
, hepatocyte nuclear factor 3-alpha
, HNF3alpha homolog B
, fork head domain-related protein 7'
, forkhead box protein A1-B
, forkhead protein 2
, hepatocyte nuclear factor 3-alpha homolog B
, transcription factor 3A
, hepatocyte nuclear factor 3 alpha
, fork head domain
, hepatocyte nuclear factor 3 alpha (winged helix transcription factor)
, hepatocyte nuclear factor 3, alpha