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The various novel mechanisms are described by which Dab2 mediates an array of signaling events with vast physiological consequences.
In conclusion, DAB2 and Intelectin-1 (zeige ITLN1 Proteine) are newly identified positive markers of mesothelioma and have potential to be included in future immunohistochemical marker panels for differentiation of epithelioid mesothelioma from pulmonary adenocarcinoma
cathepsin B (CTSB (zeige CTSB Proteine)) inhibition or expression of a CTSB (zeige CTSB Proteine)-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-beta (zeige TGFB1 Proteine)-treated cells from autophagy to apoptosis
abundances of megalin (zeige LRP2 Proteine) and Dab2 (p = 0.046) were reduced in infected placentas from women with LBW deliveries
Data show that miR106b was frequently up-regulated in human cervical carcinoma tumors and cell lines and inversely correlated with DAB2 expression. Its regulation in under TGF-beta1 (zeige TGFB1 Proteine) which contributes to cell migration by targeting DAB2 in cervical carcinoma.
these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages
inhibition of WNT (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling by DAB2 is essential for establishing the correct number of cardiomyocytes in the developing heart.
DAB2 regulated the cell migration associated genes in PC3 (zeige PCSK1 Proteine) cells, and the differential DAB2 expression between LNCaP and PC3 (zeige PCSK1 Proteine) cells was partly regulated by histone 4 acetylation.
Dab2 depletion also increases the rescued protein half-life of DeltaF508 CFTR (zeige CFTR Proteine) by ~18% and ~91%, respectively
These results indicated that miR (zeige MLXIP Proteine)-93 plays an important role in the initiation and progression of NPC (zeige NPC1 Proteine) by targeting Dab2 and the miR (zeige MLXIP Proteine)-93/Dab2 pathway may contribute to the development of novel therapeutic strategies for NPC (zeige NPC1 Proteine) in the future.
The combination of Arh (zeige LDLRAP1 Proteine) and Dab2 is responsible for the majority of adaptor function in LDLR (zeige LDLR Proteine) endocytosis and LDLR (zeige LDLR Proteine)-mediated cholesterol homeostasis.
Results identified a novel activation marker, DAB2, which expression is significantly different between microglia activation stages M2a and either M1 or M2b.
Dab2 expression is induced by hormones
Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis
Disabled-2 is required for efficient hemostasis and platelet activation by thrombin (zeige F2 Proteine) in mice.
Akt1 (zeige AKT1 Proteine) and Akt2 (zeige AKT2 Proteine) are involved in albumin (zeige ALB Proteine) endocytosis, and phosphorylation of Dab2 by Akt (zeige AKT1 Proteine) induces albumin (zeige ALB Proteine) endocytosis in proximal tubule epithelial cells.
Study of dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. Also, Dab2 has a physiological role in the endocytosis of lipoproteins and cholesterol metabolism.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2, and NR3C1 (zeige NR3C1 Proteine). TNF (zeige TNF Proteine) and IL6 (zeige IL6 Proteine) levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
, disabled homolog 2
, disabled homolog 2, mitogen-responsive phosphoprotein
, disabled homolog 2-like
, differentially-expressed protein 2
, mitogen-responsive phosphoprotein
, DOC-2 p82 isoform
, disabled homolog 2 mitogen-responsive phosphoprotein