DAB2 Proteine (DAB2)

Bezeichnung:
Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) Proteine (DAB2)
Auf www.antikoerper-online.de finden Sie aktuell 7 Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen DAB2 Antikörper (91) und DAB2 Kits (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 111 DAB2 Produkte verfügbar.
Synonyme:
5730435J12Rik, AA960054, AI957090, D15Wsu122e, D630005B22Rik, Doc-2, Doc2, p96
alle Proteine anzeigen Gen GeneID UniProt
DAB2 1601 P98082
DAB2 13132 P98078
DAB2 79128 O88797

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Human Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) Interaktionspartner

  1. In conclusion, DAB2 and Intelectin-1 (zeige ITLN1 Proteine) are newly identified positive markers of mesothelioma and have potential to be included in future immunohistochemical marker panels for differentiation of epithelioid mesothelioma from pulmonary adenocarcinoma

  2. cathepsin B (CTSB (zeige CTSB Proteine)) inhibition or expression of a CTSB (zeige CTSB Proteine)-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-beta (zeige TGFB1 Proteine)-treated cells from autophagy to apoptosis

  3. abundances of megalin (zeige LRP2 Proteine) and Dab2 (p = 0.046) were reduced in infected placentas from women with LBW deliveries

  4. Data show that miR106b was frequently up-regulated in human cervical carcinoma tumors and cell lines and inversely correlated with DAB2 expression. Its regulation in under TGF-beta1 (zeige TGFB1 Proteine) which contributes to cell migration by targeting DAB2 in cervical carcinoma.

  5. these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages

  6. inhibition of WNT (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling by DAB2 is essential for establishing the correct number of cardiomyocytes in the developing heart.

  7. DAB2 regulated the cell migration associated genes in PC3 (zeige PCSK1 Proteine) cells, and the differential DAB2 expression between LNCaP and PC3 (zeige PCSK1 Proteine) cells was partly regulated by histone 4 acetylation.

  8. Dab2 depletion also increases the rescued protein half-life of DeltaF508 CFTR (zeige CFTR Proteine) by ~18% and ~91%, respectively

  9. These results indicated that miR (zeige MLXIP Proteine)-93 plays an important role in the initiation and progression of NPC (zeige NPC1 Proteine) by targeting Dab2 and the miR (zeige MLXIP Proteine)-93/Dab2 pathway may contribute to the development of novel therapeutic strategies for NPC (zeige NPC1 Proteine) in the future.

  10. DAB2 expression is decreased in Non-Small Cell Lung Cancer , and the frequent methylation event at sites -86 to 226 of the DAB2 gene could contribute to the downregulation of DAB2.

Mouse (Murine) Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) Interaktionspartner

  1. The combination of Arh (zeige LDLRAP1 Proteine) and Dab2 is responsible for the majority of adaptor function in LDLR (zeige LDLR Proteine) endocytosis and LDLR (zeige LDLR Proteine)-mediated cholesterol homeostasis.

  2. cathepsin B (CTSB (zeige CTSB Proteine)) inhibition or expression of a CTSB (zeige CTSB Proteine)-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-beta (zeige TGFB1 Proteine)-treated cells from autophagy to apoptosis

  3. Results identified a novel activation marker, DAB2, which expression is significantly different between microglia activation stages M2a and either M1 or M2b.

  4. these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages

  5. Dab2 expression is induced by hormones

  6. Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis

  7. Disabled-2 is required for efficient hemostasis and platelet activation by thrombin (zeige F2 Proteine) in mice.

  8. Akt1 (zeige AKT1 Proteine) and Akt2 (zeige AKT2 Proteine) are involved in albumin (zeige ALB Proteine) endocytosis, and phosphorylation of Dab2 by Akt (zeige AKT1 Proteine) induces albumin (zeige ALB Proteine) endocytosis in proximal tubule epithelial cells.

  9. Study of dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. Also, Dab2 has a physiological role in the endocytosis of lipoproteins and cholesterol metabolism.

  10. miR (zeige MLXIP Proteine)-145 regulates the migration and invasion of highly invasive prostate cancer cells through targeting DAB2 gene

Cow (Bovine) Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) Interaktionspartner

  1. Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2, and NR3C1 (zeige NR3C1 Proteine). TNF (zeige TNF Proteine) and IL6 (zeige IL6 Proteine) levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.

DAB2 Protein Überblick

Protein Überblick

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with DAB2

  • disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2)
  • disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (dab2)
  • Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) (dab2)
  • Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) (DAB2)
  • Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) (Dab2)
  • disabled 2, mitogen-responsive phosphoprotein (Dab2)
  • 5730435J12Rik Protein
  • AA960054 Protein
  • AI957090 Protein
  • D15Wsu122e Protein
  • D630005B22Rik Protein
  • Doc-2 Protein
  • Doc2 Protein
  • p96 Protein

Bezeichner auf Proteinebene für DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) , disabled homolog 2 , disabled homolog 2, mitogen-responsive phosphoprotein , disabled homolog 2-like , differentially-expressed protein 2 , mitogen-responsive phosphoprotein , C9 , DOC-2 p82 isoform , disabled homolog 2 mitogen-responsive phosphoprotein

GENE ID SPEZIES
461905 Pan troglodytes
694349 Macaca mulatta
100019082 Monodelphis domestica
100066655 Equus caballus
100075899 Ornithorhynchus anatinus
100171587 Pongo abelii
100337568 Xenopus laevis
100411016 Callithrix jacchus
100484738 Ailuropoda melanoleuca
100485591 Xenopus (Silurana) tropicalis
100593149 Nomascus leucogenys
1601 Homo sapiens
100734816 Cavia porcellus
13132 Mus musculus
79128 Rattus norvegicus
427449 Gallus gallus
479353 Canis lupus familiaris
100519746 Sus scrofa
509221 Bos taurus
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