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ITGA2b expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b levels reflect variation in exposure to activation signals.
Thrombopoietin (zeige THPO Proteine)/MPL (zeige MPL Proteine) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (zeige MECOM Proteine) leukemia.
Direct binding of kindlin-3 (zeige FERMT3 Proteine) to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.
ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.
reduction of talin-beta3 integrin (zeige ITGB3 Proteine) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding
deficiency of Dok-2 leads to dysregulated integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulation.
Platelets lacking ERp57 (zeige PDIA3 Proteine) have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57 (zeige PDIA3 Proteine), implicating surface ERp57 (zeige PDIA3 Proteine) in platelet aggregation.
Data indicate that Pyk2 (zeige PTK2B Proteine) is a common signaling effector downstream of both G12 (zeige TCF3 Proteine)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.
These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen.
identified Hic-5 (zeige TGFB1I1 Proteine) as a novel and specific regulatory factor for thrombin (zeige F2 Proteine)-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.
Case Report: Reduced binding of mutant FLNa (zeige FLNA Proteine) to beta3 and the facilitated recruitment of talin by beta3 on platelet stimulation, explaining the increased alphaIIbbeta3 activation and the ensuing gain-of-platelet functions.
Mechanistic basis for the binding of fibrinogen-derived RGD- and AGDV-peptides to the platelet integrin alphaIIb-beta3 has been described.
the contribution of PAR1 (zeige MARK2 Proteine) and PAR4 (zeige PAWR Proteine) to thrombin (zeige F2 Proteine)-mediated activation of the platelet fibrin receptor (GPIIbIIIa), is reported.
The most common HPA (zeige HPSE Proteine) genotypes among Saudis were HPA-1 (zeige HPSE Proteine) a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA (zeige HPSE Proteine)-4 a + b- (99%), HPA-5 (zeige ITGA2 Proteine) a + b- (76.5%), HPA (zeige HPSE Proteine)-6 a + b- (100%) and HPA (zeige HPSE Proteine)-15 a + b + (50%). The prevalent allele among the HPA (zeige HPSE Proteine) systems was (a), except in the HPA (zeige HPSE Proteine)-15 system where the (b) allele was found in 52% of the subjects.
Integrin alpha-IIb beta-3 dependent ERK (zeige EPHB2 Proteine) signaling is regulated by Src (zeige SRC Proteine) and Rho kinases in both Leu33 and Pro33 polymorphic isoforms.
Data suggest that CD41 and CD45 (zeige PTPRC Proteine) expression marked the onset of haemangioblastoma (HB) neovascularisation and the stepwise development of the angioformative period, and also the underlying therapeutic targets of anti-vascular treatment.
ITGA2B and ITGA8 have roles in prognosis in clear cell renal cell carcinoma (zeige MOK Proteine) patients
Thirteen variants in the ITGA2B locus and 29 variants in the ITGB3 (zeige ITGB3 Proteine) locus were identified.
This study shows correlation of blood clot stiffness with platelet integrin alpha-IIb beta3 activity, aspirin usage, and transfusion risk in cardiopulmonary bypass patients.
Data show that immune thrombocytopenia (ITP (zeige ITPA Proteine)) is an autoimmune bleeding disorder characterized by low platelet count and presence of IgG autoantibodies to platelet surface glycoproteins, such as alpha IIbbeta3 integrins.
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
, GPalpha IIb
, alpha IIb
, integrin alpha-IIb
, platelet glycoprotein IIb of IIb/II Ia complex
, platelet membrane glycoprotein IIb
, platelet fibrinogen receptor, alpha subunit
, platelet-specific antigen BAK