C646, p300/CBP Inhibitor

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Applikation
Blocking Reagent (BR), Inhibition Assay (InhA)
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Verwendungszweck A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor
Produktmerkmale A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor (Ki = 400 nM). Specific inhibition to p300 (86 %) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (< 10 %). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.
Reinheit ≥ 98 % by NMR
Chemical Name (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Formel C₂₄H₁₉N₃O₆
Permeabilität Cell-permeable
Löslichkeit DMSO (25 mM)
Molekulargewicht 445.42 g/mol
CAS-Nummer 328968-36-1
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Solid
Handhabung Protect from light and air
Lagerung -20 °C
Haltbarkeit 36 months
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 image for C646, p300/CBP Inhibitor (ABIN809530) C646, p300/CBP Inhibitor
Produkt verwendet in: Chen, Wang, Uttarwar, vanKrieken, Li, Chen, Gao, Ghayur, Margetts, Krepinsky: "SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells." in: Journal of molecular cell biology, Vol. 6, Issue 6, pp. 516-30, 2015 (PubMed).