Caspase-5 Inhibitor Z-WEHD-FMK

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Applikation
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Verwendungszweck A caspase-4 inhibitor
Sequenz Z-Trp-Glu(OMe)-His-Asp(OMe)-FMK
Produktmerkmale PubChem CID: 44134610
A synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Reinheit > 99 % by HPLC
Chemical Name Z-WEHD-FMK, Caspase-5 Inhibitor (fluoromethylketone)
Formel C₃₇H₄₂FN₇O₁₁
Permeabilität Cell-permeable
Löslichkeit DMSO
Molekulargewicht 763.78 g/mol
Applikationshinweise We recommend using 1000-5000X dilutions for inhibiting caspase-5 activity in Jurkat cell culture (e.g., Add 1 µL to 1-5 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 10 mM
Handhabung Protect from light and moisture
Lagerung -20 °C
Haltbarkeit 12 months
Produkt verwendet in: Burm, Zuiderwijk-Sick, t Jong, van der Putten, Veth, Kondova, Bajramovic: "Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 2, pp. 678-87, 2015 (PubMed).

Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Coletti, Yang, Marazzi, Sassoon: "TNFalpha inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways." in: The EMBO journal, Vol. 21, Issue 4, pp. 631-42, 2002 (PubMed).