Caspase-2 Inhibitor Z-VDVAD-FMK

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Applikation
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Verwendungszweck A caspase-4 inhibitor
Sequenz Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK
Produktmerkmale PubChem CID: 44135215
A synthetic peptide that irreversibly inhibits activity of caspase-2. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Reinheit > 98 % by HPLC
Chemical Name Z-VDVAD-FMK, Caspase-2 Inhibitor, Z-VDVAD-fluoromethylketone
Formel C₃₂H₄₆FN₅O₁₁
Permeabilität Cell-permeable
Löslichkeit DMSO
Molekulargewicht 695.7 g/mol
Applikationshinweise We recommend using 1000-5000X dilutions for inhibiting caspase-2 activity in Jurkat cell culture (e.g., Add 0.2-1 µL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 10 mM
Handhabung Protect from light and moisture
Lagerung -20 °C
Haltbarkeit 12 months
Bilder des Herstellers
 image for Caspase-2 Inhibitor Z-VDVAD-FMK (ABIN412390) Caspase-2 Inhibitor Z-VDVAD-FMK
Produkt verwendet in: Chen, Liou, Chen, Chen, Hu, Wang, Lin: "Coenzyme Q10 rescues ethanol-induced corneal fibroblast apoptosis through the inhibition of caspase-2 activation." in: The Journal of biological chemistry, Vol. 288, Issue 17, pp. 11689-704, 2013 (PubMed).

Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Yen, Mar, Craciunescu, Edwards, Zeisel: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).