Dexamethasone (10 mM)

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Applikation
Functional Studies (Func), Enzyme Activity Assay (EAA), Inhibition Assay (InhA)
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Produktmerkmale PubChem CID: 5743
Reinheit > 99 % by TLC
Chemical Name 9α-Fluoro-16α-methylprednisolone, Prednisolone F, (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
Formel C₂₂H₂₉FO₅
Permeabilität Cell-permeable
Löslichkeit Solubility: Soluble in ethanol (25 mg/mL)
Molekulargewicht 392.46 g/mol
CAS-Nummer 50-02-2
Kommentare

An anti-inflammatory glucocorticoid. Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC50 = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37 °C

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Handhabung Protect from light and moisture
Lagerung -20 °C
Haltbarkeit 6 months
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 image for Dexamethasone (10 mM) (ABIN412363) Dexamethasone (10 mM)
Produkt verwendet in: Kudrin, Scott, Martin, Chung, Donn, McMaster, Ellison, Ray, Ray, Binks: "Human macrophage migration inhibitory factor: a proven immunomodulatory cytokine?" in: The Journal of biological chemistry, Vol. 281, Issue 40, pp. 29641-51, 2006 (PubMed).