Caspase-6 Inhibitor Z-VEID-FMK

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Applikation
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Verwendungszweck A caspase-4 inhibitor
Sequenz Z-Val-E(OMe)-Ile-Asp(OMe)-FMK
Produktmerkmale PubChem CID: 44135214
VEID is the specific recognition sequence for caspase-6/Mch2. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Reinheit > 98 % by HPLC
Chemical Name Z-VEID-FMK, Caspase-6 Inhibitor, VEID-FMK, VEID fluoromethylketone
Formel C₃₁H₄₅FN₄O₁₀
Permeabilität Cell-permeable
Löslichkeit DMSO
Molekulargewicht 652.9 g/mol
Applikationshinweise We recommend using 1000-5000X dilutions for inhibiting caspase-6 activity in Jurkat cell culture (e.g., Add 1 µL to 1-5 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 10 mM
Handhabung Protect from light and moisture
Lagerung -20 °C
Haltbarkeit 6-12 months
Produkt verwendet in: Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Pelizon, dAdda di Fagagna, Farrace, Laskey: "Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis." in: EMBO reports, Vol. 3, Issue 8, pp. 780-4, 2002 (PubMed).

Yen, Mar, Craciunescu, Edwards, Zeisel: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).