Z-DEVD-FMK

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Applikation
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Verwendungszweck A caspase-3 inhibitor
Sequenz Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK
Produktmerkmale A synthetic peptide that irreversibly inhibits activity of DEVD-dependent caspases (e.g., caspase-3 and caspase-7) and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Reinheit Single spot by TLC
Chemical Name Z-DEVD-FMK, Z-DEVD-fluoromethylketone, Caspase-3 inhibitor (fluoromethylketone)
Formel C₃₀H₄₁FN₄O₁₂
Permeabilität Cell-permeable
Löslichkeit DMSO (20 mM)
Molekulargewicht 668.7 g/mol
Applikationshinweise We recommend using 2-10 µM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Solid, Lyophilized
Handhabung Protect from light and moisture
Lagerung -20 °C
Haltbarkeit 12 months
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 image for Z-DEVD-FMK (ABIN412076) Z-DEVD-FMK
Produkt verwendet in: Moon, Kim, Gao, Quan, Qin, Osorio, Rosas, Wu, Tesfaigzi, Jin: "CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 307, Issue 4, pp. L326-37, 2014 (PubMed).

Kim, Amarnani, Gnanaguru, Tseng, Vavvas, DAmore: "Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms." in: Investigative ophthalmology & visual science, Vol. 55, Issue 8, pp. 4747-58, 2014 (PubMed).

Pianu, Lefort, Thuiliere, Tabourier, Bartolini: "The Aβ₁₋₄₂ peptide regulates microtubule stability independently of tau." in: Journal of cell science, Vol. 127, Issue Pt 5, pp. 1117-27, 2014 (PubMed).

Heinhuis, Koenders, van den Berg, Netea, Dinarello, Joosten: "Interleukin 32 (IL-32) contains a typical ?-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5733-43, 2012 (PubMed).

Du, Yamamoto, Ueda, Suzuki, Tano, Kamei: "Activated protein C rescues the retina from ischemia-induced cell death." in: Investigative ophthalmology & visual science, Vol. 52, Issue 2, pp. 987-93, 2011 (PubMed).

Ariazi, Cunliffe, Lewis-Wambi, Slifker, Willis, Ramos, Tapia, Kim, Yerrum, Sharma, Nicolas, Balagurunathan, Ross, Jordan: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011 (PubMed).

Hara, Senga, Biswas, Hasegawa, Ito, Hyodo, Hirooka, Niwa, Goto, Hamaguchi: "Recovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP α1/SHP-2 signaling system." in: Cancer research, Vol. 71, Issue 4, pp. 1229-34, 2011 (PubMed).

Verma, Jain, Caseltine, Rennels, Bhattacharya, Markiewski, Rawat, Neethling, Bickel, Weidanz: "TCR mimic monoclonal antibodies induce apoptosis of tumor cells via immune effector-independent mechanisms." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 5, pp. 3265-76, 2011 (PubMed).

Vogt, Harmata, Coulombe, Bross, Blackstone: "Causes and consequences of stolon regression in a colonial hydroid." in: The Journal of experimental biology, Vol. 214, Issue Pt 19, pp. 3197-205, 2011 (PubMed).

Abdul-Ghani, Dufort, Stiles, De Repentigny, Kothary, Megeney: "Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals." in: Molecular and cellular biology, Vol. 31, Issue 1, pp. 163-78, 2010 (PubMed).

Zhong, Carney, Boyan, Schwartz: "17β-Estradiol regulates rat growth plate chondrocyte apoptosis through a mitochondrial pathway not involving nitric oxide or MAPKs." in: Endocrinology, Vol. 152, Issue 1, pp. 82-92, 2010 (PubMed).

Hirata, Osuga, Takamura, Kodama, Hirota, Koga, Yoshino, Harada, Takemura, Yano, Taketani: "Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells." in: Endocrinology, Vol. 151, Issue 11, pp. 5468-76, 2010 (PubMed).

Cunningham, Giuffrida, Roberts: "Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta." in: Endocrinology, Vol. 150, Issue 12, pp. 5539-48, 2009 (PubMed).