Z-VDVAD-FMK

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Applikation
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Verwendungszweck A caspase-4 inhibitor
Sequenz Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK
Produktmerkmale A synthetic peptide that irreversibly inhibits activity of caspase-2. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Reinheit Single spot by TLC
Chemical Name Z-VDVAD-FMK, Z-VDVAD-fluoromethylketone, Caspase-2 Inhibitor (fluoromethylketone)
Formel C₃₂H₄₆FN₅O₁₁
Permeabilität Cell-permeable
Löslichkeit DMSO (20 mM)
Molekulargewicht 695.7 g/mol
Applikationshinweise We recommend using 2-10 µM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Solid, Lyophilized
Handhabung Protect from light and moisture
Lagerung -20 °C
Haltbarkeit 12 months
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 image for Z-VDVAD-FMK (ABIN412074) Z-VDVAD-FMK
Produkt verwendet in: Pianu, Lefort, Thuiliere, Tabourier, Bartolini: "The Aβ₁₋₄₂ peptide regulates microtubule stability independently of tau." in: Journal of cell science, Vol. 127, Issue Pt 5, pp. 1117-27, 2014 (PubMed).

Chang, Lin, Wu, Kuo, Wu, Shieh, Gean, Chen, Chen, Wu, Tai, Tseng: "Mechanisms underlying benzyl alcohol cytotoxicity (triamcinolone acetonide preservative) in human retinal pigment epithelial cells." in: Investigative ophthalmology & visual science, Vol. 52, Issue 7, pp. 4214-22, 2011 (PubMed).

Ariazi, Cunliffe, Lewis-Wambi, Slifker, Willis, Ramos, Tapia, Kim, Yerrum, Sharma, Nicolas, Balagurunathan, Ross, Jordan: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011 (PubMed).

Höglund, Nilsson, Forshell, Maclean, Nilsson: "Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine." in: Blood, Vol. 113, Issue 18, pp. 4281-8, 2009 (PubMed).

Nakajima, Nishimura, Nakaima, Oh, Noguchi, Taniguchi, Tamura: "Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 30, pp. 12448-52, 2009 (PubMed).

Upton, Austgen, Nishino, Coakley, Hagen, Han, Papa, Oakes: "Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress." in: Molecular and cellular biology, Vol. 28, Issue 12, pp. 3943-51, 2008 (PubMed).