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TRPP2 and TRPV4 are mechanosensitive channels in the endocardium.Oscillatory flow modulates mechanosensitive klf2a expression through trpv4 and trpp2 during heart valve development.
TRPP2 utilizes TRPV4 to form a mechano- and thermosensitive molecular sensor in the cilium.
Age-dependence of heat-activated seizure susceptibility mimicks the mRNA expression of TRPV4 and glutamate (zeige GRIN2A ELISA Kits) receptors.
TRPV4 present in all sensory organs of adult zebrafish.
Study reports cloning of a zebrafish trpv4 cDNA and assaying its expression during embryogenesis; trpv4 is expressed as maternal mRNA in 4-cell embryos and later zygotic expression is first observed in the forming notochord at the one somite stage.
OS-9 (zeige OS9 ELISA Kits) regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation.
the results of this study suggest that clinical evaluation of patients with musculoskeletal disorders similar to the peripheral neuropathies or skeletal dysplasias with scoliosis that have been ascribed to the TRPV4 spectrum could consider whether the phenotypes might result from somatic mosaicism in the target tissues affected in these phenotypes.
A novel causative variant in the TRPV4 identified in a fetus with metatropic dysplasia in third trimester of pregnancy.
reduced tissue osmolarity, likely following proteoglycan (zeige Vcan ELISA Kits) degradation, can increase TRPV4 signalling and enhance pro-inflammatory cytokine production.
A novel TRPV4 mutation implicating TRPV4 and altered calcium homeostasis in the pathogenesis of osteonecrosis was identified while reinforcing the importance of TRPV4 in bone diseases and vascular endothelium.
both TRPV2 (zeige TRPV2 ELISA Kits) and TRPV4 are involved in migration of human cardiac c-kit (zeige KIT ELISA Kits)(+) progenitor cells.
Data show that arylalkymine N-acetyltransferase (AANAT (zeige AANAT ELISA Kits)) levels and melatonin synthesis change after transient receptor potential channel 4 (zeige TRPC4 ELISA Kits) (TRPV4 channel) stimulation in ciliary body epithelial cells .
TRPV4-induced calcium mobilization and inflammatory responses were enhanced in cystic fibrosis transmembrane conductance regulator (zeige CFTR ELISA Kits)-deficient cellular models.
direct electrophysiological and pharmacological evidence for both TRPV4 and L-type Ca2 (zeige CA2 ELISA Kits)+ conductances, as well as a tetraethylammonium (TEA)- and paxilline-sensitive K+ conductance in human pulmonary fibroblasts.
We demonstrate that pharmacological activation or inhibition of TRPV4 regulates Ca(2 (zeige CA2 ELISA Kits)+)-wave propagation from head to tail. Such findings may have wide application in male fertility-infertility, contraception and conservation of endangered species as well.
These results confirm the function of TRPV4 in human cultured adipocytes and its regulation by insulin (zeige INS ELISA Kits).
Our observations thus suggest that the TRPV4 ion channel is involved in mechanotransduction in juxtaglomerular cells.
TRPV4-knockout mice were protected from D. farinae-induced airway remodeling. TRPV4 modulated matrix remodeling in the lung via 2 distinct but dependent pathways: one enhances matrix deposition by fibrotic gene activation, whereas the other slows down matrix degradation by increased plasminogen activator inhibitor 1 (zeige SERPINE1 ELISA Kits).
Study found that hypotonicity in the portal circulation, probably sensed by TRPV4 channels, triggers the osmopressor response and intact renal nerves are needed for the full response.
Altogether, these data identify a novel reciprocal functional link between TRPV4 activation and TGFbeta1 (zeige TGFB1 ELISA Kits) signals regulating dermal myofibroblast differentiation. These findings suggest that therapeutic inhibition of TRPV4 activity may provide a targeted approach to the treatment of scleroderma.
Dynamic coupling between TRPV4 and Ca(2 (zeige CA2 ELISA Kits)+)-activated SK1 (zeige SPHK1 ELISA Kits)/3 and IK1 (zeige KCNN4 ELISA Kits) K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 (zeige KCNMA1 ELISA Kits) in kidney collecting duct cells.
TRPV4 channels are important for bladder afferent signaling. TRPV4 -/- mice bladders generate more noxious sensory output, which is predominantly mediated through TRPV1 (zeige TRPV1 ELISA Kits) expressing high threshold nerve fibers.
TRPV4 does not play a major role in the kidney or is efficiently compensated when deleted. TRPV4 is critical for the release of vasopressin (zeige AVP ELISA Kits), the sensation of thirst, and the central osmoregulation.
These results suggest that the Na(+) signal generated in Nax (zeige SCN7A ELISA Kits)-positive glial cells leads to the activation of TRPV4-positive neurons in sCVOs to stimulate water intake by using EETs as gliotransmitters.
TRPV4 plays a critical role in the transduction of mechanical forces and gets activated by cell swelling and surface expansion.
The absence of TRPV4-ATP-mediated effects on C-fibers indicates a distinct neurobiology for this ion channel and implicates TRPV4 as a novel therapeutic target for neuronal hyperresponsiveness in the airways and symptoms, such as cough.
Data indicate a physiologic function of transient receptor potential vanilloid 4 (TRPV4) in the regulation of blood-cerebrospinal fluid barrier (BCSFB) permeability.
Hyposmotic shock-induced TRPV4 channel activation regulates hemichannel-mediated ATP release and Na-K-ATPase (zeige ATP1A1 ELISA Kits) activity in lens epithelium.
The large amounts of transported calcium and the short signaling ways suggest a potentially important role of TRPV4 in many physiological processes.
TRPV4 is present in articular chondrocytes in swine, and chondrocyte response to hypo-osmotic stress is mediated by this channel, which involves both an extracellular Ca(2 (zeige CA2 ELISA Kits)+) and intracellular Ca(2 (zeige CA2 ELISA Kits)+) release.
TRPV4 channels activity in bovine articular chondrocytes are regulated by obesity-associated mediators.
TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene.
transient receptor potential cation channel subfamily V member 4
, transient receptor potential cation channel, subfamily V, member 4
, transient receptor potential cation channel subfamily V member 4-like
, OSM9-like transient receptor potential channel 4
, osm-9-like TRP channel 4
, osmosensitive transient receptor potential channel 4
, transient receptor potential protein 12
, vanilloid receptor-like channel 2
, vanilloid receptor-related osmotically activated channel
, vanilloid receptor-like protein 2
, vanilloid receptor-related osmotically-activated channel
, transient receptor potential cation channel, subfamily 5, member 4
, vanilloid receptor-related osmotically activated channel (Vroac)
, vanilloid receptor-related osmotically activated channel protein