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TRPP2 and TRPV4 are mechanosensitive channels in the endocardium.Oscillatory flow modulates mechanosensitive klf2a expression through trpv4 and trpp2 during heart valve development.
TRPP2 utilizes TRPV4 to form a mechano- and thermosensitive molecular sensor in the cilium.
Age-dependence of heat-activated seizure susceptibility mimicks the mRNA expression of TRPV4 and glutamate (zeige GRIN2A ELISA Kits) receptors.
TRPV4 present in all sensory organs of adult zebrafish.
Study reports cloning of a zebrafish trpv4 cDNA and assaying its expression during embryogenesis; trpv4 is expressed as maternal mRNA in 4-cell embryos and later zygotic expression is first observed in the forming notochord at the one somite stage.
OS-9 (zeige OS9 ELISA Kits) regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation.
TRPV4 involvement in RVD depends on the type of stimuli and/or degree of channel activation, leading to a maximum RVD response when Ca(2 (zeige CA2 ELISA Kits)+) influx overcomes a threshold and activates further signaling pathways in cell volume regulation.
Studies demonstrate that TRPV4 play a leading function in many fibrotic disease. Increasing evidence shows that TRPV4 modulated fibroblasts proliferation and differentiation to myofibroblasts. While in cystic fibrosis (zeige S100A8 ELISA Kits), the defective regulatory volume decrease might be caused by the absence TRPV4 and in pancreatic fibrosis, TRPV4 serves as a sensor responsive to inflammation, hypotonic saline and pain. [review]
Arg594His substitution in TRPV4 causes SMD Kozlowski type.
Data show that transient receptor potential vanilloid 4 (TRPV4)expression is enhanced in a subset of basal breast cancers.
studies identified TRPV4 as a channel that contributes to both histamine- and chloroquine-induced itch and indicated that the function of TRPV4 in itch signaling involves TRPV1 (zeige TRPV1 ELISA Kits)-mediated facilitation.
the results of this study suggest that clinical evaluation of patients with musculoskeletal disorders similar to the peripheral neuropathies or skeletal dysplasias with scoliosis that have been ascribed to the TRPV4 spectrum could consider whether the phenotypes might result from somatic mosaicism in the target tissues affected in these phenotypes.
A novel causative variant in the TRPV4 identified in a fetus with metatropic dysplasia in third trimester of pregnancy.
reduced tissue osmolarity, likely following proteoglycan (zeige Vcan ELISA Kits) degradation, can increase TRPV4 signalling and enhance pro-inflammatory cytokine production.
A novel TRPV4 mutation implicating TRPV4 and altered calcium homeostasis in the pathogenesis of osteonecrosis was identified while reinforcing the importance of TRPV4 in bone diseases and vascular endothelium.
both TRPV2 (zeige TRPV2 ELISA Kits) and TRPV4 are involved in migration of human cardiac c-kit (zeige KIT ELISA Kits)(+) progenitor cells.
These results suggest that TRPV4, TRPV3 and TRPM8 proteins, but not their ion channel activities are necessary for the induction of CIPs at 32 degrees C. Identification of proteins that differentially interact with these TRP channels at 37 degrees C and 32 degrees C would help elucidate the underlying mechanisms of CIP induction by hypothermia.
we show that TRPV4 is activated both by damage associated molecular pattern HMGB1 (zeige HMGB1 ELISA Kits) and collagen in diseased Kupffer cells that in turn activate the endothelial NOS (NOS3 (zeige NOS3 ELISA Kits)) to release nitric oxide (NO). The diffusible NO acts in a paracrine fashion in neighboring hepatocytes to deactivate the redox toxicity induced by CYP2E1 (zeige CYP2E1 ELISA Kits)
these data suggest that TRPV4 regulates angiogenesis endogenously via modulation of endothelial cells mechanosensitivity
Our observations thus suggest that the TRPV4 ion channel is involved in mechanotransduction in juxtaglomerular cells.
TRPV4-knockout mice were protected from D. farinae-induced airway remodeling. TRPV4 modulated matrix remodeling in the lung via 2 distinct but dependent pathways: one enhances matrix deposition by fibrotic gene activation, whereas the other slows down matrix degradation by increased plasminogen activator inhibitor 1 (zeige SERPINE1 ELISA Kits).
Study found that hypotonicity in the portal circulation, probably sensed by TRPV4 channels, triggers the osmopressor response and intact renal nerves are needed for the full response.
Altogether, these data identify a novel reciprocal functional link between TRPV4 activation and TGFbeta1 (zeige TGFB1 ELISA Kits) signals regulating dermal myofibroblast differentiation. These findings suggest that therapeutic inhibition of TRPV4 activity may provide a targeted approach to the treatment of scleroderma.
Dynamic coupling between TRPV4 and Ca(2 (zeige CA2 ELISA Kits)+)-activated SK1 (zeige SPHK1 ELISA Kits)/3 and IK1 (zeige KCNN4 ELISA Kits) K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 (zeige KCNMA1 ELISA Kits) in kidney collecting duct cells.
TRPV4 channels are important for bladder afferent signaling. TRPV4 -/- mice bladders generate more noxious sensory output, which is predominantly mediated through TRPV1 (zeige TRPV1 ELISA Kits) expressing high threshold nerve fibers.
findings also indicate that TRPV4 channels are mechanosensors in neonatal pig preglomerular vascular SMCs and contribute to renal myogenic autoregulation
Data indicate a physiologic function of transient receptor potential vanilloid 4 (TRPV4) in the regulation of blood-cerebrospinal fluid barrier (BCSFB) permeability.
Hyposmotic shock-induced TRPV4 channel activation regulates hemichannel-mediated ATP release and Na-K-ATPase (zeige ATP1A1 ELISA Kits) activity in lens epithelium.
The large amounts of transported calcium and the short signaling ways suggest a potentially important role of TRPV4 in many physiological processes.
TRPV4 is present in articular chondrocytes in swine, and chondrocyte response to hypo-osmotic stress is mediated by this channel, which involves both an extracellular Ca(2 (zeige CA2 ELISA Kits)+) and intracellular Ca(2 (zeige CA2 ELISA Kits)+) release.
TRPV4 channels activity in bovine articular chondrocytes are regulated by obesity-associated mediators.
TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene.
transient receptor potential cation channel subfamily V member 4
, transient receptor potential cation channel, subfamily V, member 4
, transient receptor potential cation channel subfamily V member 4-like
, OSM9-like transient receptor potential channel 4
, osm-9-like TRP channel 4
, osmosensitive transient receptor potential channel 4
, transient receptor potential protein 12
, vanilloid receptor-like channel 2
, vanilloid receptor-related osmotically activated channel
, vanilloid receptor-like protein 2
, vanilloid receptor-related osmotically-activated channel
, transient receptor potential cation channel, subfamily 5, member 4
, vanilloid receptor-related osmotically activated channel (Vroac)
, vanilloid receptor-related osmotically activated channel protein