Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
The pregnane X receptor (zeige NR1I2 ELISA Kits) down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 (zeige SRC ELISA Kits) coactivator.
Variants of SLC22A1 gene are associated with serum acylcarnitines and metabolic diseases.
Results indicate that the interaction between OCT1 (zeige POU2F1 ELISA Kits) and SERT (zeige SLC6A4 ELISA Kits) genes might play an important role in metformin gastrointestinal intolerance.
summarize current understanding of human OCT1 (zeige POU2F1 ELISA Kits) transporter hepatic gene regulation and propose potential post-transcriptional regulation by predicted miRNAs.
The response to 6 months of metformin treatment (HbA1c , homeostasis model assessment for insulin (zeige INS ELISA Kits) resistance, fasting insulin (zeige INS ELISA Kits), and glucose changes) did not differ between SLC22A1 wild-type subjects and carriers of presumably low-activity SLC22A1 alleles
we assessed the role of miR (zeige MLXIP ELISA Kits)-21 in mediating renal cell carcinoma chemoresistance and further showed that miR (zeige MLXIP ELISA Kits)-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2 (zeige SLC22A2 ELISA Kits), and SLC31A1/CTR1 (zeige SLC31A1 ELISA Kits) platinum influx transporter expression
This condensed chromatin structure is associated with binding of DNMT3B and decreased occupancy of OCT1 transcription factor at MAML2 enhancer, suggesting a role of DNMT3B in increasing methylation of MAML2 after stilbenoid treatment.
genetic association studies in population of patients newly diagnosed type 2 diabetes in Bosnia and Herzegovina: Data suggest that genetic variations in OCT1 (zeige POU2F1 ELISA Kits) [R61C (rs12208357); M420del (rs72552763)] are associated with severe intolerance/gastrointestinal side effects due to metformin use in patients with type 2 diabetes.
This study indicates a promising role for intratumoral OCT1 (zeige POU2F1 ELISA Kits) mRNA expression as a prognostic biomarker in therapeutic algorithms in HCC (zeige FAM126A ELISA Kits)
Data show that bisindolylmaleimides (BIMs) Ro 31-8220 also blocks activity of the solute carrier organic cation transporter 1 (OCT1), involved in uptake of marketed drugs in the liver, in a protein kinase C (PKC (zeige PKC ELISA Kits))-independent manner.
Dopamine transport across the olfactory and respiratory mucosae is partially mediated by organic cation transporters, including OCT-1 (zeige POU2F1 ELISA Kits) and OCT-2 (zeige SLC22A2 ELISA Kits).
Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 (zeige SLC22A2 ELISA Kits) and Slc22a3 (zeige OCT3 ELISA Kits) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (zeige TSC1 ELISA Kits)+/-renal tumours.
Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.
The influence of organic cation transporters 1, 2, and 3 (OCT1 (zeige POU2F1 ELISA Kits), OCT2 (zeige SLC22A2 ELISA Kits), and OCT3 (zeige POU5F1 ELISA Kits)) and their genetic variants on cellular uptake of picoplatin and on the individual components of the ensuing cytotoxicity such as DNA adduct formation, was determined.
Oct1 (zeige POU2F1 ELISA Kits) forms repeating, cyclosporin-sensitive regulatory modules within the CD21 (zeige CR2 ELISA Kits) intronic control region.
a comparison of the transport properties of Oct2 (zeige SLC22A2 ELISA Kits) and Oct1 (zeige POU2F1 ELISA Kits)
oct1 (zeige POU2F1 ELISA Kits) has a role in controlling fgl2 (zeige FGL2 ELISA Kits) expression in endothelial cells
This study shows that Oct1 (zeige POU2F1 ELISA Kits) and Oct2 (zeige SLC22A2 ELISA Kits) together are essential for renal secretion of (small) organic cations.
nuclear factor Y and Oct-1 bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated expression of the mGnRH receptor gene
The purpose of this study was to examine the effects of peroxisome proliferator agonist receptor agonists on the hepatic regulation and function of Slc22a1.
a multiprotein complex containing GATA-1, Oct-1, and other protein factors may contribute to the formation of a repressive chromatin structure that silences gamma-globin gene expression
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.
solute carrier family 22 member 1
, solute carrier family 22 (organic cation transporter), member 1
, solute carrier family 22 member 1-like
, organic cation transporter 1
, solute carrier family 22, member 1
, solute carrier family 22 (organic cation transporter), member 2