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High RAB11B expression is associated with pancreatic cancer.
Rab11A (zeige RAB11A Proteine) and Rab11B differentially regulate intracellular trafficking of PAR1 (zeige MARK2 Proteine) through distinct endosomal sorting mechanisms
we determined a crystal structure of the PKG (zeige PRKG1 Proteine) II LZ-Rab11b complex. The PKG (zeige PRKG1 Proteine) II LZ domain presents a mostly nonpolar surface onto which Rab11b docks, through van (zeige TNIP1 Proteine) der (zeige GDF3 Proteine) Waals interactions
Upon Rab11b depletion, FGFR4 (zeige FGFR4 Proteine) is trapped in the pericentriolar recycling compartment.
the predominant mechanism of melanin transfer is keratinocyte-induced exocytosis, mediated by Rab11b through remodeling of the melanosome membrane, followed by subsequent endocytosis by keratinocytes
Data show that the cAMP/PKA/CREB (zeige CREB1 Proteine) signaling pathway initiates acidosis-induced V-ATPase (zeige ATP6V1H Proteine) trafficking in salivary ducts via regulation of Rab11b expression.
These findings reveal a novel role for Rab11b in limiting, rather than promoting, the plasma membrane expression of Cav1.2 (zeige CACNA1C Proteine) L-type Ca2 (zeige CA2 Proteine)+ channels.
These data introduce Rab11b as a crucial regulator and Rip11 (zeige RAB11FIP5 Proteine) as mediator of acidosis-induced V-ATPase (zeige ATP6V1H Proteine) traffic in duct cells of submandibular gland.
propose a model where Rab11B specifically transports vesicles derived from the Golgi to the immature Inner Membrane Complex of the growing daughter parasites.
structural analysis shows Rab11 (zeige RAB11A Proteine) isoforms may possess different GTP (zeige AK3 Proteine) hydrolysis rates
these data show an interaction between the smallGTPase Rab11b and the BK channel (zeige KCNMA1 Proteine), which suggests that BK is shuttledthrough a slow recycling endocytic pathway.
These data indicate that Rab11b, and to a lesser extent Rab11a (zeige RAB11A Proteine), is involved in establishing the constitutive and cAMP-stimulated Na(+) transport in mpkCCD cells.
These data indicate that Rab11b is necessary for the trafficking of cGK-II and that the cGMP/cGK-II signaling pathway is closely related to Rab11b recycling pathway.
Data show that in huntingtin-null embryonic stem cells, the levels of Rab11 on membranes and nucleotide exchange activity on Rab11 are significantly reduced compared with normal embryonic stem cells.
Study shows that both Rab11 (zeige RAB11A Proteine) and its effector Rip11 (zeige RAB11FIP5 Proteine) participate in insulin (zeige INS Proteine) granule exocytosis and that Rip11 (zeige RAB11FIP5 Proteine), as a substrate of PKA, regulates the potentiation of exocytosis by cAMP in pancreatic beta-cells.
The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994
ras-related protein Rab-11B
, GTP-binding protein YPT3
, RAB11B, member of RAS oncogene family