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anti-Rat (Rattus) MYO5A Antikörper:
anti-Mouse (Murine) MYO5A Antikörper:
anti-Human MYO5A Antikörper:
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Human Polyclonal MYO5A Primary Antibody für ELISA, ICC - ABIN4337383
Röder, Choi, Reischl, Petersen, Diefenbacher, Zaccolo, Pozzan, Rudolf: Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 2 Pubmed References
Rab11 (zeige RAB11A Antikörper) and the associated motor protein (zeige MYO7A Antikörper) Myosin V play essential roles in both endogenous and ectopic apical constriction, and might be involved in Vangl2 trafficking to the cell surface.
function of two coupled myosin va motors on actin filaments and bundles
MyoVa-Ca(2 (zeige CA2 Antikörper)+) channel interactions are required for proper long-range axon growth in developing spinal cord in vivo.
Myo5c-globular tail domain and Myo5a-globular tail domain are not interchangeable in terms of inhibiting the motor function.
This study showed that spontaneous Myo5a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
These results visualize many of the critical unknown aspects of the stepping mechanism of myosin 5 including head-head coordination, the origin of lever-arm motion and the spatiotemporal dynamics of the translocating head during individual steps.
Motor coupling through lipid membranes enhances transport velocities for ensembles of myosin Va.
Microtubules retard a centrifugal transport process that is dependent on myosin-Va and a population of dynamic F-actin. Functional analysis of mutant proteins indicates that myosin-Va works as a transporter dispersing melanosomes along actin tracks.
Normal physiological processes of relaxation of gastric and cavernosal smooth muscles that facilitate food accommodation and penile erection, respectively, may be disrupted under conditions of myosin Va deficiency.
Data demonstrate that myosin-Va is a component of a heterogeneous population of ribonucleoprotein particles of different sizes and composition, both in brain and peripheral nervous system
Myosin Va associates with FMRP (zeige FMR1 Antikörper) and is required for its correct intracellular localisation.
ETV6-NTRK3, MYO5A-NTRK3 and MYH9-NTRK3 fusions are identified in Spitz tumours and demonstrated that NTRK3 fusions constitutively activate the mitogen-activated protein kinase, phosphoinositide 3-kinase and phospholipase Cgamma1 pathways in melanocytes.
the inhibited Myo5a is equilibrated between the folded state, in which the Mlph (zeige MLPH Antikörper)-binding site is buried, and the preactivated state, in which the Mlph (zeige MLPH Antikörper)-binding site is exposed, and that Mlph (zeige MLPH Antikörper) is able to bind to the Myo5a in preactivated state and activates its motor function.
These findings reveal a new fast-acting energy conservation strategy halting growth by immobilizing myosin V in a newly described state on selectively stabilized actin cables.
Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c.
Data indicate that myosin Va interacted with multiple new Rab (zeige HRB Antikörper) subfamilies including Rab6 (zeige RAB6A Antikörper), Rab14 (zeige RAB14 Antikörper) and Rab39B (zeige RAB39B Antikörper).
several crystal structures of the myosin Va or the myosin Vb globular tail domain that gives insights into how the motor is linked to the recycling membrane compartments via Rab11 (zeige RAB11A Antikörper) or the melanophilin (zeige MLPH Antikörper) adaptor that binds to Rab27a (zeige RAB27A Antikörper).
the cargo-binding domain (CBD (zeige OPN1MW Antikörper)) structures of the three human MyoV paralogs (Va, Vb, and Vc), revealing subtle structural changes that drive functional differentiation and a novel redox mechanism controlling the CBD (zeige OPN1MW Antikörper) dimerization process
myosin-Va promotes adhesion dynamics, anchorage-independent survival, migration, and invasion in vitro
Myosin Va plays a role in the transport and turnover of mRNA. [Review]
Calmodulin (zeige CALM1 Antikörper) bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a.
Calmodulin (zeige KRIT1 Antikörper) bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a.
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.
, heavy polypeptide 12
, myosin VA (heavy polypeptide 12, myoxin)
, myosin Va
, myosin va
, dilute myosin heavy chain, non-muscle
, myosin 5a
, unconventional myosin-Va
, dilute lethal-20J protein
, myosin 5A
, myosin I heavy chain isoform
, myosin VA (heavy chain 12, myoxin)
, myosin heavy chain P190
, myosin V
, myosin, heavy polypeptide kinase