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Loss of function of either PTHR1 (zeige PTH1R Antikörper) or PTHrP in zebrafish leads to a localized aortic defect that is Notch (zeige NOTCH1 Antikörper) dependent.
In normal cartilage development, sox9 (zeige SOX9 Antikörper) upregulates pthlh, which downregulates runx2 (zeige RUNX2 Antikörper), and that the duplicated nature of all three of these genes in zebrafish creates a network of regulation by different co-orthologs in different tissues.
this is the first time that mutation recurrence has been detected in PTHLH associated with brachydactyly type E and we have observed that, as remarked before, this syndrome has high intrafamilial as well as interfamilial variability
Antagonistic antibodies against the death receptors demonstrated that Apo2L (zeige TNFSF10 Antikörper)/TRAIL mediated its apoptotic signals through activation of the TRAIL-R2 (zeige TNFRSF10B Antikörper) in PTHrP expressing breast cancer cells
Amino PTHrP and carboxyl PTHrP can vary independently in different lung carcinomas. Carboxyl PTHrP may temper the stimulatory effect of amino PTHrP on cancer progression.
PTHLH is a gastrin (zeige GAST Antikörper)-regulated growth factor that might contribute to gastric epithelial cell homeostasis.
Duplication of PTHLH co-segregates with osteochondroplasia with a combined brachydactyly type E/A1 in a three-generation pedigree.
Data shown here expand the knowledge on the phenotypic presentation of PTHLH mutations, highlighting significant clinical variability and incomplete penetrance of the PTHLH-related symptoms.
We showed that the supplementation of the osteogenic differentiation medium with PTHrP inhibited the alkaline phosphatase activity and the expression of the transcription factor DLX3 (zeige DLX3 Antikörper), but the depletion of PTHrP did not support the differentiation of DFCs.We showed that SUFU (Suppressor Of Fused Homolog (zeige SUFUH Antikörper)) was not regulated during the osteogenic differentiation in DFCs
High expression of PTHRP is associated with Tongue squamous cell carcinoma.
No relationship between plasma PTHrP levels and failure of tooth eruption, dental manifestations of pseudohypoparathyroidism or brachydactyly was found.
we report three patients affected with brachydactyly type E, caused by PTHLH mutations expected to result in haploinsufficiency, and discuss our data compared to published reports.
PTHLH and PTHR1 (zeige PTH1R Antikörper) were evaluated as functional candidate genes for their effects on number and shape of teats in pigs
To investigate the roles of mammary PTHrP in calcium uptake and/or release in the mammary gland of cows, plasma PTHrP and Ca levels, and their arterial-venous differences were examined in a Jersey cow during the periparturient period.
ECM1 (zeige ECM1 Antikörper) seems to be critical for PTHrP action in chondrogenesis, as blockage of ECM1 (zeige ECM1 Antikörper) nearly abolishes PTHrP regulation of chondrocyte hypertrophy, and overexpression of ECM1 (zeige ECM1 Antikörper) rescues disorganized growth plates of PTHrP-null mice; ECM1 (zeige ECM1 Antikörper) and progranulin (zeige GRN Antikörper) chondrogenic growth factor constitute an interaction network.
The truncated PTHrP (1-84) led to abnormal subpopulations, impaired proliferation and increased apoptosis in the thymus, indicating that PTHrP is involved in the development of T cells, and the NLS (zeige ALDH1A2 Antikörper) and C-terminus part is necessary for the normal role of PTHrP in T-cell development.
PTHrP(1-36) significantly enhances beta cell regeneration through increased beta cell proliferation and beta cell mass after Partial Pancreatectomy
An accelerated hypertrophic differentiation caused by a disturbed Ihh (zeige IHH Antikörper)-PTHrP signaling pathway may lead to a higher bone mineral density in the vertebral bodies of newborn Col (zeige HDAC1 Antikörper) IX -/- mice and, as a result, to the early onset of disc degeneration.
Data show that parathyroid hormone-related protein (PTHrP) regulates gremlin (zeige GREM1 Antikörper) levels in pancreatic acinar and stellate cells.
nuclear localization sequence and C-terminus play a critical role in preventing skin from premature ageing partially mediated by p27 (zeige CDKN1B Antikörper)
the p27 (zeige CDKN1B Antikörper) pathway may function downstream in the action of PTHrP to regulate skeletal growth and development.
Data demonstrate that the deletion of cyclin-dependent kinase inhibitor p27 (p27 (zeige CDKN1B Antikörper)) in parathyroid hormone like hormone (Pthrp) knock-in(KI/KI (zeige AXIN1 Antikörper)) mice can partially rescue defects in dental and mandibular development.
The ventral signal observed from E12.5 on colocalized with motor neuron markers Isl1 (zeige ISL1 Antikörper)/2 and FoxP1 (zeige FOXP1 Antikörper) and The strong ventral signal colocalizing wtth Isl1 (zeige ISL1 Antikörper)/2 was observed in all rostrocaudal segments of the spinal cord.
the pro-survival role of PTHrP in goat mammary epithelial cells may be regulated by DeltaFosB.
PTHrP overexpression protects goat mammary gland epithelial cells from CaSR (zeige CASR Antikörper) activation-induced apoptosis.
Data show that signal transducer and activator of transcription 5a (Stat5a (zeige STAT5A Antikörper)) reduces the mRNA expression of parathyroid hormone-related protein (PTHrP) in mammary gland epithelial cells (GMECs).
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.
parathyroid hormone-like hormone
, parathyroid hormone-related protein
, PTH-related protein
, parathyroid hormone-like related protein
, parathyroid hormone related protein
, parathyroid hormone-like peptide
, parathyroid hormone-like protein
, parathyroid-like peptide
, parathyroid hormone-related peptide
, PTH-related peptide
, Parathyroid hormone-related protein
, antioxidant enzyme B166
, liver tissue 2D-page spot 2D-0014IV
, peroxiredoxin 6
, peroxiredoxin V
, peroxiredoxin-5, mitochondrial
, peroxisomal antioxidant enzyme
, peroxisomal membrane protein 20
, thioredoxin peroxidase PMP20
, thioredoxin reductase