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This report is the first to indicate lowered concentrations of calcitonin gene-related peptide (CGRP) as part of the metabolic changes during milk fever in cows.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
The reciprocal changes in SST (zeige SST Proteine) and histamine secretion in gastric Helicobacter infection were due to release of CGRP from sensory neurons.
Substance P (zeige TAC1 Proteine) and CGRP correlate with the occurrence and development of allergic rhinitis.
These results establish that calcitonin gene-related peptide (CGRP) regulates HIV-1 degradation in Langerhans cells (LCs). As CGRP (zeige S100A12 Proteine) contributes to the sexual response and present within mucosal epithelia, HIV-1 proteasomal degradation in LCs might predominate in vivo and should be enhanced clinically.
Diagnostic value of sTREM-1, IL-8 (zeige IL8 Proteine), PCT (zeige UROD Proteine), and CRP (zeige CRP Proteine) in febrile neutropenia after autologous stem cell transplantation
PCT (zeige UROD Proteine) and CRP (zeige CRP Proteine) are reliable markers of infection and correlate with infection severity in children with liver disease.
The intrapatellar fat pad (zeige PADI4 Proteine) of knee osteoarthritis patients produces relatively high levels of CGRP (zeige S100A12 Proteine).
CGRP (zeige S100A12 Proteine) and IL-4 (zeige IL4 Proteine) positively regulated APN/CD13 (zeige ANPEP Proteine) expression and activity in psoriatic fibroblasts.
Preoperative calcitonin levels were correlated with the presence of tumor, whereas alkaline phosphatase (ALP) levels were not. There were no significant associations between tumor volume and ALP (zeige ALP Proteine) or calcitonin levels in the preoperative or postoperative periods. During long-term follow-up, serum ALP (zeige ALP Proteine) was significantly associated with tumor recurrence, but serum calcitonin was not.
PCT (zeige UROD Proteine) median values were significantly higher in patients with sepsis than without during the first 10 postoperative days after cardiac surgery.
Point-of-care procalcitonin test can be used to substantially reduce antibiotic exposure in patients hospitalized with acute exacerbation of COPD (zeige ARCN1 Proteine).
Data suggest CGRP (zeige S100A12 Proteine) receptor (CGRPR (zeige CALCRL Proteine)) ECL2 (extracellular loop 2 domain) enables interaction with N-terminal residues of CGRP (zeige S100A12 Proteine); this provides evidence for dual involvement of ECL2 in two-domain binding model of CGRP (zeige S100A12 Proteine)/CGRPR (zeige CALCRL Proteine) interaction; CGRPR (zeige CALCRL Proteine) is obligate heterodimer of CLR (zeige DCLK3 Proteine)/RAMP1 (zeige RAMP1 Proteine). (CGRP (zeige S100A12 Proteine) = calcitonin gene-related peptide; CLR (zeige DCLK3 Proteine) = calcitonin receptor-like receptor (zeige CALCRL Proteine); RAMP1 (zeige RAMP1 Proteine) = receptor [calcitonin] activity modifying protein 1)
Elevated Expression of PCT (zeige UROD Proteine) is associated with Sepsis.
High level of co-expression of PACAP (zeige ADCYAP1 Proteine) with VIP (zeige Vip Proteine), SP and CGRP in the distal ganglia of the vagus sensory perikarya directly implicates studied peptides in their functional interaction during nociceptive vagal transduction.
This study demonstrated for the first time a strong expression of NGF, TrkA, CGRP, nNOS and neuronal specific enolase in the majority of esophageal enteric nervous system components.
Localization of calcitonin gene related peptide in the nerve fibers of porcine cystic ovaries
Calcitonin is a regulator of the 25-hydroxyvitamin D3 1alpha-hydroxylase (zeige CYP27B1 Proteine) gene.
CGRP-antibodies can be used as markers for type II neurons in the pig small intestinal myenteric plexus in quantitative studies but it should be kept in mind that up to one-tenth of CGRP-reactive neurons may be non-type II neurons.
The data provide morphological evidence confirming expression of CGRP in the porcine spinal nuclei while its coexpression in cholinergic neurons suggests that CGRP may play a role in modulation of the spinal cholinergic transmission.
results indicate that CGRP regulates macrophage polarization and inhibits inflammation in murine macrophages.
In addition to its actions in the cardiovascular system, endogenous CGRP is a key regulator of metabolism and energy homeostasis in vivo.
findings establish CGRP neurons in the parabrachial nucleus as key mediators of cancer-induced appetite suppression and associated behavioral changes.
These results identify an important, possibly dual role of CGRP in Amyotrophic lateral sclerosis pathogenesis.
functional inactivation of CGRP neurons markedly increases meal size, with meal frequency being reduced in a compensatory manner, and renders mice insensitive to the anorexic effects of meal-related satiety peptides.
Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (zeige ADM Proteine) (AM), adrenomedullin-2 (AM-2 (zeige ADM2 Proteine)) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
The abundance of mRNA of CGRP and bone matrix markers (Col (zeige HDAC1 Proteine) I, Col (zeige HDAC1 Proteine) II, and OPN (zeige SPP1 Proteine)) was low at P5 in the tibia. These differences in CGRP and other mRNAs may induce a different manner of ossification between the mandible and tibia. Therefore, a time lag (zeige STMN1 Proteine) of ossification occurs between the mandible and tibia during foetal development.
Suggest that cochlear function is enhanced by maturation of CGRP receptor complexes.
the generation of Tregs may be promoted by naive CD4 (zeige CD4 Proteine)+ T cell: neuron interaction through the release of neuropeptide CGRP.
The observations of this study imply that Adelta afferents expressing CGRP-IR transduce information from different sites within the skin.
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
calcitonin gene-related peptide 2
, calcitonin-related polypeptide 3
, calcitonin-related polypeptide alpha
, calcitonin/calcitonin-related polypeptide, alpha
, Calcitonin gene-related peptide
, calcitonin gene-related peptide
, alpha-type CGRP
, calcitonin 1
, calcitonin gene-related peptide I
, calcitonin gene-related peptide 1
, calcitonin gene related peptide I
, calcitonin-related polypeptide, beta
, alpha CGRP
, calcitonin/alpha CGRP