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Sonic Hedgehog Proteine (SHH)

Sonic Hedgehog Proteine (SHH)
Auf finden Sie aktuell 87 Sonic Hedgehog (SHH) Proteine von 17 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Sonic Hedgehog Antikörper (138) und Sonic Hedgehog Kits (25) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 259 Sonic Hedgehog Produkte verfügbar.
9530036O11Rik, Dsh, fc83d08, hedgehog, HHG1, HLP3, HPE3, Hx, Hxl3, M100081, MCOPCB5, SHH, SMMCI, syu, TPT, TPTPS, vhh-1, vhh1, wu:fc83d08, Xhh, xshh
alle Proteine anzeigen Gen GeneID UniProt
SHH 20423 Q62226
SHH 6469 Q15465
SHH 29499 Q63673

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Am meisten referenzierte Sonic Hedgehog Proteine

  1. Human Sonic Hedgehog Protein expressed in Escherichia coli (E. coli) - ABIN2666482 : Ingham, McMahon: Hedgehog signaling in animal development: paradigms and principles. in Genes & development 2001 (PubMed)
    Zeige alle 5 Referenzen für ABIN2666482

  2. Human Sonic Hedgehog Protein expressed in HEK-293 Cells - ABIN2181760 : Pepinsky, Zeng, Wen, Rayhorn, Baker, Williams, Bixler, Ambrose, Garber, Miatkowski, Taylor, Wang, Galdes: Identification of a palmitic acid-modified form of human Sonic hedgehog. in The Journal of biological chemistry 1998 (PubMed)
    Zeige alle 2 Referenzen für ABIN2181760

  3. Human Sonic Hedgehog Protein expressed in Human Cells - ABIN2002696 : Stone, Hynes, Armanini, Swanson, Gu, Johnson, Scott, Pennica, Goddard, Phillips, Noll, Hooper, de Sauvage, Rosenthal: The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. in Nature 1996 (PubMed)
    Zeige alle 2 Referenzen für ABIN2002696

  4. Human Sonic Hedgehog Protein expressed in Human Cells - ABIN2002699 : Ericson, Briscoe, Rashbass, van Heyningen, Jessell: Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube. in Cold Spring Harbor symposia on quantitative biology 1998 (PubMed)
    Zeige alle 2 Referenzen für ABIN2002699

Weitere Proteine zu Sonic Hedgehog Interaktionspartnern

Mouse (Murine) Sonic Hedgehog (SHH) Interaktionspartner

  1. Sufu (zeige SUFUH Proteine) is upregulated in active Shh responding tissues and accompanies Gli (zeige GLI1 Proteine) activators translocating into and Gli (zeige GLI1 Proteine) repressors out of the nucleus.

  2. Tbx2 (zeige TBX2 Proteine) and Tbx3 (zeige TBX3 Proteine) function downstream of Shh to maintain pro-proliferative mesenchymal Wnt (zeige WNT2 Proteine) signaling.

  3. cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH signaling through regulation of GLI3 (zeige GLI3 Proteine) processing.

  4. Activated microglia are major cell type for SHH expression in vivo and in vitro.

  5. these results reveal a novel role for E177-Zn(2+) in regulating SHH signaling that may involve critical, cilia basal-body localized changes in cross-linking and/or conformation.

  6. hair follicle transit-amplifying cells (HF-TACs) play an essential role in orchestrating dermal adipogenesis through secreting Sonic Hedgehog

  7. Shh acts as an endogenous mediator of mechanical stimuli on bone marrow stromal cells. Shh expression is regulated by DNA methylation (zeige HELLS Proteine).

  8. These data reveal an interaction between the cytoplasmic domains of Ptch1 (zeige PTCH1 Proteine) and that these domains modulate Ptch1 (zeige PTCH1 Proteine) activity but are not essential for regulation of the Hh pathway.

  9. These results indicate that the modulatory effects of SHH on BALB/c mouse metanephric explant cultures may involve the regulation of Fgf8 (zeige FGF8 Proteine) expression but not Fgf10 (zeige FGF10 Proteine) expression, which provides evidence for the functional role of Fgf proteins in renal morphogenesis.

  10. Wnt (zeige WNT2 Proteine), Eda (zeige EDA Proteine), and Shh have roles in touch dome Merkel cell development

Human Sonic Hedgehog (SHH) Interaktionspartner

  1. Data indicate that agedunin induces its anti-metastatic effect through inhibition of sonic hedgehog protein [SHH] signaling.

  2. findings suggest that Usp7 (zeige USP7 Proteine) is important for MB cell proliferation and metastasis by activating Shh pathway, and is a putative therapeutic target for MBs (zeige PPP1R12A Proteine)

  3. importance of MAOA (zeige MAOA Proteine) for initiating the pre-metastatic niche in stromal cells and promoting PCa (zeige FLVCR1 Proteine) metastasis to bone and visceral organs, mediated by activation of paracrine Shh-IL6 (zeige IL6 Proteine)-RANKL (zeige TNFSF11 Proteine) signaling underlying tumor-stromal interactions.

  4. Studies indicate that sonic hedgehog protein (Shh) is upregulated specifically in renal tubular epithelium.

  5. these results reveal a novel role for E177-Zn(2+) in regulating SHH signaling that may involve critical, cilia basal-body localized changes in cross-linking and/or conformation.

  6. first report of the assessment of the frequency of GLI3 (zeige GLI3 Proteine)/SHH/preZRS/ZRS in Chinese polydactyly patients to show any higher possibility of mutations or variants for the 4 genes or sequences in China

  7. These data reveal an interaction between the cytoplasmic domains of Ptch1 (zeige PTCH1 Proteine) and that these domains modulate Ptch1 (zeige PTCH1 Proteine) activity but are not essential for regulation of the Hh pathway.

  8. SHH acted exclusively in a paracrine fashion on pancreatic stellate cells and influenced the growth of Pancreatic Cancer cells only indirectly, ADM (zeige ADM Proteine) could directly impact the growth of both Pancreatic Cancer cells and pancreatic stellate cells .

  9. data implicate perturbation of the Shh pathway in at least 37% of individuals with the hypothalamic hamartoma epilepsy syndrome, consistent with the concept of a developmental pathway brain disease

  10. The results suggested that, when the rs61730970, rs200798148 and rs146535482 alleles of the Hedgehog gene lacked particular single nucleotide polymorphisms, the patients were associated with a greater risk of Hirschsprung's disease and/or anorectal malformations [HSCR (zeige EDNRB Proteine): odds ratio (OR)=1.543, P=0.004; OR=1.494, P=0.007; rs146535482: OR=1.556, P=0.003, respectively.

Xenopus laevis Sonic Hedgehog (SHH) Interaktionspartner

  1. Data indicate that sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of the regenerate.

  2. Dzip1 (zeige DZIP1 Proteine)-dependent stabilization of Spop (zeige SPOP Proteine)/HIB is evolutionarily conserved and essential for proper regulation of Gli (zeige GLI1 Proteine)/Ci proteins in the Hh pathway.

  3. Notch (zeige NOTCH1 Proteine) signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline.

  4. These results indicate that electrical activity and second-messenger signaling mediate Shh action in embryonic spinal neurons.

  5. Connective tissue-specific expression of BMP-4 (zeige BMP4 Proteine) mRNA is up-regulated by sonic hedgehog.

  6. In an examination of signaling pathways in developing Xenopus lung, shh but not ihh (zeige IHH Proteine) was expressed in the very anterior part of early lung epithelium.

  7. Data propose that Shh serves as a ventral optic tract repellent that helps to define the caudal boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.

  8. The forebrain of Xenopus revealed a largely conserved pattern of Shh expression among tetrapods.

  9. Hedgehog regulates superficial slow muscle fibres in Xenopus and tetrapod trunk myogenesis

  10. Results suggest that 7-dehydrocholesterol reductase (zeige DHCR7 Proteine) and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos

Cow (Bovine) Sonic Hedgehog (SHH) Interaktionspartner

  1. study shows evolutionary alteration of a Ptch1 (zeige PTCH1 Proteine) cis (zeige CISH Proteine)-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development

Zebrafish Sonic Hedgehog (SHH) Interaktionspartner

  1. Shh is not essential for the early activation of has2 (zeige HAS2 Proteine), but supports proper chondrogenic differentiation.

  2. Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.

  3. Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis

  4. Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity.

  5. We further demonstrate that the elevated Hedgehog signaling in Sox11 (zeige SOX11 Proteine)-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 (zeige SOX11 Proteine) morphants.

  6. Pax6 (zeige PAX6 Proteine) has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates.

  7. Sulf1 (zeige SULF1 Proteine) triggers Shh signaling activity to establish and, later on, modify the spatial arrangement of gene expression in ventral neural progenitors

  8. These studies provide evidence that a signaling pathway involving agrin (zeige AGRN Proteine), Fgfs and Shh may be a critical target of ethanol exposure during zebrafish embryogenesis.

  9. heterozygote mutations in fgf8 (zeige FGF8 Proteine), shh or oep (zeige TDGF1 Proteine) lead to a reduced number of ascending dopaminergic neurons in zebrafish and may confer increased susceptibility to the Parkinson disease

  10. Hh is able to bypass VEGF to induce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surprising complexity in the interplay between Hh and VEGF signaling during arteriovenous specification.

Sonic Hedgehog (SHH) Protein Überblick

Protein Überblick

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

Alternative names and synonyms associated with Sonic Hedgehog (SHH)

  • sonic hedgehog (shh)
  • sonic hedgehog (SHH)
  • sonic hedgehog (LOC100352774)
  • sonic hedgehog (Shh)
  • sonic hedgehog a (shha)
  • 9530036O11Rik Protein
  • Dsh Protein
  • fc83d08 Protein
  • hedgehog Protein
  • HHG1 Protein
  • HLP3 Protein
  • HPE3 Protein
  • Hx Protein
  • Hxl3 Protein
  • M100081 Protein
  • MCOPCB5 Protein
  • SHH Protein
  • SMMCI Protein
  • syu Protein
  • TPT Protein
  • TPTPS Protein
  • vhh-1 Protein
  • vhh1 Protein
  • wu:fc83d08 Protein
  • Xhh Protein
  • xshh Protein

Bezeichner auf Proteinebene für Sonic Hedgehog Proteine (SHH)

sonic hedgehog protein , sonic hedgehog , HHG-1 , hemimelic extra toes , short digits , sonic hedgehog homolog , VHH-1 , X-SHH , morphogen , sonic hedgehog protein A , sonic-you

446055 Takifugu rubripes
100049186 Oryzias latipes
100136227 Oncorhynchus mykiss
100169727 Felis catus
100352774 Oryctolagus cuniculus
100505407 Sus scrofa
20423 Mus musculus
6469 Homo sapiens
398047 Xenopus laevis
395615 Gallus gallus
608860 Canis lupus familiaris
29499 Rattus norvegicus
286821 Bos taurus
30269 Danio rerio
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