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anti-Human GLI2 Antikörper:
anti-Rat (Rattus) GLI2 Antikörper:
anti-Mouse (Murine) GLI2 Antikörper:
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Human Polyclonal GLI2 Primary Antibody für IHC, WB - ABIN2777474
Ikram, Neill, Regl, Eichberger, Frischauf, Aberger, Quinn, Philpott: GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. in The Journal of investigative dermatology 2004
Show all 24 Pubmed References
Human Polyclonal GLI2 Primary Antibody für ChIP, ELISA - ABIN269891
Won, Kim, Lim, Sung, Kim, Park, Lee, Choi: Autophagy is related to the hedgehog signaling pathway in human gastric adenocarcinoma: prognostic significance of Beclin-1 and Gli2 expression in human gastric adenocarcinoma. in Pathology, research and practice 2015
Show all 3 Pubmed References
Human Polyclonal GLI2 Primary Antibody für ICC, IF - ABIN4314278
Martinez, Kobayashi, Krishnan, Webber, Christie, Guo, Singh, Zochodne: Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen. in Experimental neurology 2015
Human Polyclonal GLI2 Primary Antibody für ELISA - ABIN547626
Haycraft, Banizs, Aydin-Son, Zhang, Michaud, Yoder: Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. in PLoS genetics 2005
Human Polyclonal GLI2 Primary Antibody für IHC, ELISA - ABIN1043881
Roessler, Ermilov, Grange, Wang, Grachtchouk, Dlugosz, Muenke: A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. in Human molecular genetics 2005
Human Polyclonal GLI2 Primary Antibody für IHC, WB - ABIN5516755
Enzenhofer, Parzefall, Haymerle, Schneider, Kadletz, Heiduschka, Pammer, Oberndorfer, Wrba, Loader, Grasl, Perisanidis, Erovic: Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy. in PLoS ONE 2016
GLI2 is a dosage-sensitive gene that may be responsible for the agenesis of corpus callosum observed in the proband.
This inhibitory effect on cell growth was partially rescued by exogenous KRT17 (zeige KRT17 Antikörper) expression. In the KRT17 (zeige KRT17 Antikörper)-positive regions in OSCCs, GLI-1 (zeige GLI1 Antikörper) or GLI-2 was frequently detected, and the number of cells with cleaved caspase-3 (zeige CASP3 Antikörper) positive was decreased. CONCLUSIONS: KRT17 (zeige KRT17 Antikörper) promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 (zeige KRT17 Antikörper) overexpression by GLIs in OSCC
Data suggest that Nrp1 (neuropilin-1 (zeige NRP1 Antikörper)) regulates Hedgehog (zeige SHH Antikörper) signaling specifically at the level of activation of GLI2 transcriptional activator function; Nrp1 (zeige NELL1 Antikörper) localization to primary cilium does not correlate with Hedgehog (zeige SHH Antikörper) signal promotion. These studies were conducted in various cell types.
studies identify a novel molecular mechanism of regulation of CD40L (zeige CD40LG Antikörper) by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 (zeige CCR3 Antikörper) signaling
the data suggest that CCRK (zeige CDK20 Antikörper) positively regulates the kinetics by which ciliary proteins such as Smoothened (zeige SMO Antikörper) and Gli2 are imported into the cilium, and that the efficiency of ciliary recruitment allows for potent responses to Hedgehog (zeige SHH Antikörper) signaling over long time periods.
GLI2 is a regulator of beta-catenin (zeige CTNNB1 Antikörper) and provides insights into its role in tumorigenesis.
bioinformatics analysis and luciferase reporter assay predicted the direct binding to miR (zeige MLXIP Antikörper)-125b-5p, which has been reported to function as a tumor suppressor in osteosarcoma. Furthermore, functional experiments validated that cir (zeige KCNJ5 Antikörper)-GLI2 exerted the tumor-promoting effects on osteosarcoma cells via negatively targeting miR (zeige MLXIP Antikörper)-125b-5p.
GANT61, which is a targeted inhibitor of Gli1 (zeige GLI1 Antikörper) and Gli2, decreased cell viability and promoted cell apoptosis. Thus, TGF-b1 induced EMT (zeige ITK Antikörper) in neuroblastoma (zeige ARHGEF16 Antikörper) cells to increase their migration. Specifically, EMT (zeige ITK Antikörper) induced by TGF-b1 in neuroblastoma (zeige ARHGEF16 Antikörper) cells did not depend on the Smad (zeige SMAD1 Antikörper) signaling pathway, and the transcription factor Gli (zeige GLI1 Antikörper) participated in TGF-b1-induced EMT (zeige ITK Antikörper) independent of Smad (zeige SMAD1 Antikörper) signaling.
These results demonstrate that miR (zeige MLXIP Antikörper)-124 is an important downstream target gene of Hh signaling, and the Gli2/miR (zeige MLXIP Antikörper)-124/AURKA (zeige AURKA Antikörper) axis is essential for the proliferation and growth of human glioma cells.
in trophoblasts, GLI2 not only directly bound to the promoter region of gene hsd11b2 (zeige HSD11B2 Antikörper) to transactivate hsd11b2 (zeige HSD11B2 Antikörper) but also formed a heterodimer with RNA polymerase II, resulting in up-regulation of hsd11b2 (zeige HSD11B2 Antikörper) gene transcription
Data indicate that the expression levels of transcription factors Gli1 (zeige GLI1 Antikörper) and Gli2 in muscle were the lowest of the 13 tissues.
The 12 SNPs of GLI2 encompassing exon 4 to exon 8 showed strong association with in the anorectal atresia in pigs.
Gli2 and Gli3 (zeige GLI3 Antikörper) are dephosphorylated and activated in cilia and that impaired Gli2 and Gli3 (zeige GLI3 Antikörper) processing in Ta3 (zeige HSP90B1 Antikörper) mutant is at least in part due to a decrease in Gli2 and Gli3 (zeige GLI3 Antikörper) phosphorylation.
Sufu (zeige SUFUH Antikörper) is upregulated in active Shh (zeige SHH Antikörper) responding tissues and accompanies Gli (zeige GLI1 Antikörper) activators translocating into and Gli (zeige GLI1 Antikörper) repressors out of the nucleus.
Gli2+/-;Gli3Delta699/+ mice can serve as a genetic mouse model for common DSD (zeige FADS1 Antikörper).
Despite increased production of full-length GLI2 and GLI3 (zeige GLI3 Antikörper) isoforms, previously identified GLI (zeige GLI1 Antikörper) targets important for mandibular and glossal development (Foxf1 (zeige FOXF1 Antikörper), Foxf2 (zeige FOXF2 Antikörper), Foxd1 (zeige FOXD1 Antikörper) and Foxd2 (zeige FOXD2 Antikörper)) were transcriptionally downregulated in Kif3a (zeige KIF3A Antikörper)(f/f);Wnt1 (zeige WNT1 Antikörper)-Cre embryos.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
the GLI2 protein level could serve as a feasible marker of ligand-dependent hedgehog (zeige SHH Antikörper) activation in pancreatic neoplasms.
Study suggested that loss of Gli2 mRNA mediated the anterior-restricted defect in conditional Dicer (zeige DICER1 Antikörper) knockdown mice and showed that miR (zeige MLXIP Antikörper)-106b positively regulated Gli2 mRNA expression
Sufu (zeige SUFUH Antikörper) deletion early in embryogenesis resulted in unstable Gli2 and Gli3 (zeige GLI3 Antikörper) activity, leading to the ectopic activation of Shh (zeige SHH Antikörper) signaling.
the three GLI (zeige GLI1 Antikörper) factors(GLI1 (zeige GLI1 Antikörper), GLI2, and GLI3 (zeige GLI3 Antikörper)) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
GLI-Kruppel family member GLI2
, glioma-associated oncogene family zinc finger 2
, oncogene GLI2
, tax helper protein 1
, tax helper protein 2
, tax-responsive element-2 holding protein
, tax-responsive element-25-bp sequence binding protein
, zinc finger protein GLI2
, Zn finger transcription factor
, zinc finger protein GLI3
, Tax helper protein