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Human SDC1 ELISA Kit für Sandwich ELISA - ABIN1446014
Andersen, Kristensen, Preiss, Christensen, Abildgaard: Upregulation of Syndecan-1 in the bone marrow microenvironment in multiple myeloma is associated with angiogenesis. in European journal of haematology 2015
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Rat (Rattus) SDC1 ELISA Kit für Sandwich ELISA - ABIN416453
Lei, Xue, Wu, Zhou, Zhang, Yuan, Wang: Increased level of soluble syndecan-1 in serum correlates with myocardial expression in a rat model of myocardial infarction. in Molecular and cellular biochemistry 2011
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Human SDC1 ELISA Kit für Sandwich ELISA - ABIN417419
Jung, Fuernau, Muench, Desch, Eitel, Schuler, Adams, Figulla, Thiele: Impairment of the endothelial glycocalyx in cardiogenic shock and its prognostic relevance. in Shock (Augusta, Ga.) 2015
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Rat (Rattus) SDC1 ELISA Kit für Sandwich ELISA - ABIN858389
Darweish, Abbas, Ebrahim, Al-Gayyar: Chemopreventive and hepatoprotective effects of Epigallocatechin-gallate against hepatocellular carcinoma: role of heparan sulfate proteoglycans pathway. in The Journal of pharmacy and pharmacology 2014
all detectable Sdc found at the NMJ is provided by the muscle, strongly suggesting a post-synaptic role for Sdc. both the cytoplasmic and extracellular domains of Sdc are required to promote synapse growth or to rescue Sdc loss of function.
We conclude that Sdc cell autonomously regulates Slit/Robo2 signalling in tracheal cells to guarantee ordered directional migration and branch fusion.
In this study, we provide evidence that Dlp (zeige DMD ELISA Kits) and Sdc have both overlapping and distinct functions in axon guidance and in defining accurate patterns of axonal fasciculation within the lateral CNS neuropil
Syndecan acting as a co-receptor for Slit in the Drosophila heart.
Syndecan (Sdc) is critical for the fidelity of Slit repellent signaling at the midline of the Drosophila CNS.
The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR (zeige PTPRF ELISA Kits) receptor tyrosine phosphatase (zeige PTPRU ELISA Kits).
Dlp (zeige DMD ELISA Kits), which lacks chondroitin sulfate (CS)modifications, participates in the transfer of Slit from its site of expression to the target cells, where CS-modified Sdc concentrates and presents the ligand.
the present study showed that serum Syndecan-1 might be a reliable marker for monitoring disease activity and renal activity in children with JSLE and lupus nephritis.
The above suggest that radiation-mediated premature senescence and invasive tumor cells, alone or in combination, enhance SDC1 expression in breast stromal fibroblasts, a poor prognostic factor for cancer growth, and that TGF-beta (zeige TGFB1 ELISA Kits) plays a crucial role in this process.
A syndecan-1 level >/=40 ng/mL identified trauma patients with significantly worse outcomes, despite admission physiology similar to those without the condition.
overexpression of syndecan-1 confers to B-LCs an increased capacity to migrate in response to Tat, owing to a switch from a CXCR4/G-protein/Rac to a syndecan-1/alphavbeta3/pp60src/pp125FAK signal transduction pathway that depends on the formation of a complex in which syndecan-1 interacts with Tat via its HS-chains, with alphavbeta3 via its core protein ectodomain and with pp60src via its intracellular tail
MiR (zeige MLXIP ELISA Kits)-331-3p-mediated miRNA maturation and enhanced epithelial-to-mesenchymal transition via effects on TGF-beta (zeige TGFB1 ELISA Kits)/Smad 4 (zeige SMAD4 ELISA Kits) and Dicer (zeige DICER1 ELISA Kits) are essential for the development of prostate cancer mediated by syndecan-1.
The heparanase (zeige HPSE ELISA Kits)/syndecan1 axis in gallbladder carcinoma cells plays an important role in the invasion and metastasis, thus providing a new therapeutic target.
Syndecan-1 acts as a novel tissue biomarker and a modulator of CSC phenotype of triple negative IBC via the IL-6 (zeige IL6 ELISA Kits)/STAT3 (zeige STAT3 ELISA Kits), Notch (zeige NOTCH1 ELISA Kits) and EGFR (zeige EGFR ELISA Kits) signaling pathways, thus emerging as a promising therapeutic target for IBC.
Hepatitis C virus infection downregulates Synd-1 and upregulates Xylt 2 (zeige XYLT2 ELISA Kits) expression, likely contributing to a major glycocalyx reshuffle within days of infection.
Soluble Sdc1 is significantly lower before the clinical onset of preeclampsia, with reduced expression of Sdc1 in the delivered placenta, suggesting a role for glycocalyx disturbance in preeclampsia pathophysiology.
Heparanase (zeige HPSE ELISA Kits) has emerged as a major regulator of cancer by degrading heparan sulfate thereby influencing multiple signaling pathways that control gene expression, syndecan shedding and cell behavior. (Review)
Syntaxin-4 (zeige STX4 ELISA Kits) not only bound to laminin but also latched onto the glycosaminoglycan side chains of syndecan-1, a laminin receptor that mediates epithelial morphogenesis. Thus, temporal extracellular extrusion of syntaxin-4 (zeige STX4 ELISA Kits) emerged as a novel regulatory element for laminin-induced mammary epithelial cell behaviors.
2-O-sulfated (zeige SULF1 ELISA Kits) domains in syndecan-1 heparan sulfate halt disease progression and promote liver repair by enhancing hepatocyte survival in acetaminophen-induced liver injury
CD138 expression on fully mature Antibody secreting cells (ASCs) provides a selective survival advantage over less mature, newly minted ASCs, by enhancing pro-survival cytokine signaling.
Sdc1 deficiency results in increased susceptibility to colitis-associated tumorigenesis.
MMP7 (zeige MMP7 ELISA Kits) shedding of syndecan-1/CXCL1 (zeige CXCL1 ELISA Kits) complexes functions as a checkpoint that restricts neutrophil activation at sites of epithelial injury.
Data show that heparanase-1 (HPA-1 (zeige HPSE ELISA Kits)) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1) facilitated the release of vascular endothelial growth factor C (VEGF-C (zeige VEGFC ELISA Kits)) from SDC-1/VEGF-C (zeige VEGFC ELISA Kits) complex into the medium of hepatocarcinoma cell.
This study indicates that, while syndecan-1 is important for providing a barrier to acute S. aureus infection in PD, it does not affect peritoneal fibrosis and angiogenesis.
Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1) and -beta-D-glucuronidase (zeige GUSB ELISA Kits) heparanase (HPSE (zeige HPSE ELISA Kits)).
Study showed the expression, distribution and function of syndecan-1 in primary sensory neurons after nerve injury
A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 (zeige ADAM17 ELISA Kits) and promotes lung epithelial tumor cell migration and lung metastasis formation.
Heparan sulfate is involved in both centralized and decentralized glycocalyx-mediated mechanotransduction, with GPC1 (zeige GPC1 ELISA Kits) acting as a centralized agent and SDC1 functioning in decentralized mechanotransmission. GPC1 (zeige GPC1 ELISA Kits) mediates NOS3 (zeige NOS3 ELISA Kits) activation.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
, syndecan 1
, CD138 antigen
, heparan sulfate proteoglycan fibroblast growth factor receptor
, syndecan proteoglycan 1