Heparan-Sulfate 6-O-Sulfotransferase 1 Proteine (HS6ST1)

Heparan-Sulfate 6-O-Sulfotransferase 1 Proteine (HS6ST1)
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6OST1, CHS6ST-1, HH15, HS6ST, HS6ST-1
alle Proteine anzeigen Gen GeneID UniProt
HS6ST1 50785 Q9QYK5
Ratte HS6ST1 HS6ST1 316325  
HS6ST1 9394 O60243

Weitere Synonyme anzeigen

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Mouse (Murine) Heparan-Sulfate 6-O-Sulfotransferase 1 (HS6ST1) Interaktionspartner

  1. Distinct expression patterns of Sulf1 (zeige SULF1 Proteine) and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.

  2. both HS6ST-1 and HS6ST-2 (zeige HS6ST2 Proteine) are involved in 6-O-sulfation of heparin and that the proper packaging and storage of tryptase (zeige TPSAB1 Proteine)

  3. 6OST1 is predominantly transcribed in epithelial and neural-derived tissues during development

  4. Data show that high expression of 6-O-sulfotransferase (6-OST)-1, 2, or 3 resulted in increased 6-O-sulfation of N-sulfated (zeige SULF1 Proteine) and N-acetylated glucosamine units, and in altered heparan sulfate domain structure.

  5. Hs2st and/or Hs6st1 expression coincides with Slit expression domains at locations where retinal ganglion cell(RGC) axons make navigation errors in Hs2st-/- and Hs6st1-/- mutants, and Hs6st1-/-RGC axons are less sensitive to Slit2 repulsion.

  6. there is a critical role for HS 6-O sulfation by Hs6st1 in postnatal processes

Human Heparan-Sulfate 6-O-Sulfotransferase 1 (HS6ST1) Interaktionspartner

  1. HS6ST-1 and HS6ST-2 (zeige HS6ST2 Proteine) have roles in regulating the angiogenic program in ovarian cancer cells affecting HB-EGF (zeige HBEGF Proteine) signaling and subsequent expression of angiogenic cytokines by cancer cells

  2. Hs6st1 and Hs2st (zeige HS2ST1 Proteine) generate conditions conducive to corpus callosum development.

  3. idiopathic hypogonadotrophic hypogonadism--associated HS6ST1 mutations display reduced activity in vitro and in vivo, suggesting that HS6ST1 and the complex modifications of extracellular sugars are critical for normal development

  4. we have characterized HS6ST-2 (zeige HS6ST2 Proteine) and HS6ST-1 human isologues, including their chromosomal localizations,HS6STs could also transfer sulphate to N -sulphoglucosamine residues located at the non-reducing terminal of HS with high affinity.

Heparan-Sulfate 6-O-Sulfotransferase 1 (HS6ST1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene.

Alternative names and synonyms associated with Heparan-Sulfate 6-O-Sulfotransferase 1 (HS6ST1)

  • heparan sulfate 6-O-sulfotransferase 1 (Hs6st1)
  • heparan sulfate 6-O-sulfotransferase 1 (HS6ST1)
  • 6OST1 Protein
  • CHS6ST-1 Protein
  • HH15 Protein
  • HS6ST Protein
  • HS6ST-1 Protein

Bezeichner auf Proteinebene für HS6ST1

HS6ST-1 , heparan-sulfate 6-O-sulfotransferase 1 , mHS6ST-1 , heparan-sulfate 6-sulfotransferase , Heparan-sulfate 6-O-sulfotransferase 1 , heparan sulfate 6-sulfotransferase

50785 Mus musculus
316325 Rattus norvegicus
9394 Homo sapiens
395141 Gallus gallus
100688113 Canis lupus familiaris
100689173 Cricetulus griseus
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