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Thus, GPC6 and TMEM132D may serve as predictors of CD8 (zeige CD8A Antikörper)+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis.
GPC6 promotes invasive migration by inhibition of canonical beta-catenin (zeige CTNNB1 Antikörper) and Wnt (zeige WNT2 Antikörper) signalling, and up-regulation of non-canonical Wnt5A (zeige WNT5A Antikörper) signalling leading to the activation of JNK (zeige MAPK8 Antikörper) and p38 MAPK (zeige MAPK14 Antikörper).
a reduction in GPC6 mRNA in retinoblastoma is associated with the non-random allelic loss at 13q31 that could contribute to RB development.
Mutations in the heparan-sulfate proteoglycan glypican 6 impair endochondral ossification and cause recessive omodysplasia
Adult female Gpc6-/- mice were compared with wild-type control mice of identical C57BL/6 background. Consistent with the phenotype of omodysplasia 1, Gpc6-/-mice had femurs and vertebrae that were shorter than those of wild-type mice. They also had increased femoral bone mineral content and increased cortical thickness.
GPC6 stimulates Hh signaling by binding to Hh and Ptc1 (zeige PTCH1 Antikörper) at the cilium and increasing the interaction of the receptor and ligand to promote the growth of developing long bones.
data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate (zeige GRIN1 Antikörper) receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.
, glypican proteoglycan 6