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Human Biglycan ELISA Kit für Sandwich ELISA - ABIN423825
Maishi, Ohba, Akiyama, Ohga, Hamada, Nagao-Kitamoto, Alam, Yamamoto, Kawamoto, Inoue, Taketomi, Shindoh, Hida, Hida: Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan. in Scientific reports 2016
study reports a temporal relationship between altered placental biglycan expression and subsequent development of fetal growth restriction/small for gestational age.
Quantitative polymerase chain reaction for messenger RNA expression from tissue specimens revealed significantly higher expression of Biglycan (p = 0.0008) and Lumican (zeige LUM ELISA Kits) (p = 0.01) and lower expression of Decorin (zeige DCN ELISA Kits) (p < 0.0001) in urothelial carcinoma of bladder
Mutation in BGN gene is associated with X-Linked Spondyloepimetaphyseal Dysplasia.
biglycan exerts an important role in cell proliferation, migration, invasion and apoptosis in colon cancer.
BGN might play an important role on metastasis in human endometrial cancer and it might be a target marker for the molecular therapy of advanced and recurrence endometrial cancer.
This study demonstrated that the small leucine-rich proteoglycan (zeige Vcan ELISA Kits) BGN accumulates in CADASIL (zeige NOTCH3 ELISA Kits) and binds to NOTCH3 (zeige NOTCH3 ELISA Kits).
Biglycan may have a role in development of vascular damage in smokers
BGN is a factor secreted by peritubular cells to modulate FGFR3c signaling and thus contributes to the regulation of spermatogonial maintenance
The results suggest that regions within BGN is associated with ACL (zeige ACLY ELISA Kits) injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties.
immunolocalization of decorin (zeige DCN ELISA Kits) and biglycan in samples of first-trimester and term placentas, placenta accreta, invasive mole, and choriocarcinoma
Biglycan plays a protective role during the progression of atherosclerosis in ApoE (zeige APOE ELISA Kits)-deficient mice by inhibiting thrombin (zeige F2 ELISA Kits) generation.
These genes were concordantly induced by TAC (zeige IL2RA ELISA Kits) in WT but not in biglycan KO mice. CONCLUSIONS: Left ventricular pressure overload induces biglycan expression in cardiac fibroblasts. Ablation of biglycan improves cardiac function and attenuates left ventricular hypertrophy and fibrosis after long-term pressure overload.
Importance of biglycan and decorin (zeige DCN ELISA Kits) as targets for the manipulation of fetal membrane extracellular matrix stability in the context of inflammation.
Biglycan deficiency leads to loosely packed aortic collagen fibers, increased susceptibility of aortic elastin (zeige ELN ELISA Kits) fibers to angII-induced stress, and up-regulation of vascular perlecan (zeige HSPG2 ELISA Kits) content.
Biglycan signaling supported fetal membrane remodeling during early gestation in the absence of concomitant changes in TGFbeta (zeige TGFB1 ELISA Kits) levels.
Lumican (zeige LUM ELISA Kits) and biglycan influence corneal keratocyte lamellipodia organization and are critical in the regulation of stromal collagen fibrillogenesis.
Biglycan-triggered TLR-2 (zeige TLR2 ELISA Kits)- and TLR-4 (zeige TLR4 ELISA Kits)-signaling exacerbates the pathophysiology of ischemic acute kidney injury.
De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88 (zeige MYD88 ELISA Kits)/TRIF (zeige RNF138 ELISA Kits) pathways.
Early stage patellar tendon healing was inferior in biglycan-null and decorin (zeige DCN ELISA Kits)-null mice as compared to wild type.
This suggests that biglycan and decorin (zeige DCN ELISA Kits) may have sequential roles in the tendon response to injury.
Bgn regulates BMP4 (zeige BMP4 ELISA Kits) signaling through modulation of Chordin (zeige CHRD ELISA Kits) anti-BMP4 (zeige BMP4 ELISA Kits) activity.
LDL electrostatic interactions with decorin (zeige DCN ELISA Kits) and biglycan in the aortic valve leaflets and vascular wall is a major source of LDL retention.
Data show that biglycan, collagen type I, collagen type II, decorin (zeige DCN ELISA Kits), and versican (zeige Vcan ELISA Kits) were significantly affected by vibration duration, frequency, and amplitude.
biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a few minutes
biglycan-induced fibroblast cytoskeletal and signalling changes result in an increased cell migration; potential role in the remodelling process
The results indicate that CTGF (zeige CTGF ELISA Kits) suppresses the synthesis of biglycan but newly induced that of decorin (zeige DCN ELISA Kits) in the cells when the cell density is low.
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex.
, biglycan proteoglycan
, bone/cartilage proteoglycan I
, bone/cartilage proteoglycan-I
, dermatan sulphate proteoglycan I
, small leucine-rich protein 1A
, Small proteoglycan I (biglycan), bone (BSPG1) (bone/cartilage proteclycan 1 precursor)
, bone/cartilage proteclycan 1
, leucine-rich PG I