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GNAO1 Proteine (GNAO1)

Bezeichnung:
Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O Proteine (GNAO1)
Auf www.antikoerper-online.de finden Sie aktuell 19 Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O (GNAO1) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen GNAO1 Antikörper (69) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 94 GNAO1 Produkte verfügbar.
Synonyme:
alphaO, AW050213, G-ALPHA-o, Galphao, Gnao, gnao1, gnao1-A, RATBPGTPC, wu:fq26h05, XGalpha01, zgc:73315
alle Proteine anzeigen Gen GeneID UniProt
GNAO1 2775 P09471
GNAO1 50664 P59215
GNAO1 14681 P18872

Weitere Synonyme anzeigen

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Weitere Proteine zu GNAO1 Interaktionspartnern

Human Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O (GNAO1) Interaktionspartner

  1. authors report 2 cases of brothers with a severe movement disorder and hypotonia without epilepsy who have been confirmed by whole exome sequencing to have a novel mutation in GNAO1

  2. Phenotypic spectrum of novel GNAO1 variants in four unrelated female patients included epileptic encephalopathy and involuntary movements with severe developmental delay.

  3. GNAO1 is a disease-causing gene for the autosomal dominant form of early infantile epileptic encephalopathy. The novel pathogenic variant identified in should contribute to our understanding of the expanding spectrum of infantile-onset epilepsy.

  4. Endothelial cells in capillary malformations are enriched for GNAQ mutations and are likely responsible for the pathophysiology underlying capillary malformation.

  5. Galphao-R243H has a mild decrease in nucleotide affinity that causes rapid nucleotide turnover and subsequent hyperactivity in cancer

  6. Genetic variants of BCL2, GNAO1, and CHD2 are associated with non-obstructive azoospermia risk.

  7. the present study is the first to demonstrate that GNAO1 is overexpressed in GC and that its overexpression correlates with poor prognosis, as it promotes gastric cancer cell viability.

  8. Down-regulation of GNAO1 increases cell proliferation, while suppressing the senescence of hepatocellular carcinoma cells.

  9. These data suggest that aberrant Galphao signaling can cause multiple neurodevelopmental phenotypes, including epileptic encephalopathy and involuntary movements.

  10. Data show that HEK293T cells transfected with estrogen receptor alpha (ERalpha (zeige ESR1 Proteine))+/-Galpha(o) revealed that Galpha(o) stimulated phosphorylation of ERK (zeige EPHB2 Proteine) MAP kinases ERK 1 (zeige MAPK3 Proteine)/2 and subsequently increased the phosphorylation of ERalpha (zeige ESR1 Proteine) on serine 118.

Cow (Bovine) Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O (GNAO1) Interaktionspartner

  1. These results indicated the interaction of GAP-43 (zeige GAP43 Proteine) and Galpha(o) could accelerate conversion of depalmitoylated Galpha(o) but not palmitoylated Galpha(o) from oligomers to monomers, so as to increase the GTPgammaS binding activity of Galpha(o).

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O (GNAO1) Interaktionspartner

  1. Data obtained support the hypothesis that GalphaO-mediated signaling within the presympathetic circuits of the rostral ventral lateral medulla contributes to the autonomic control of the heart.

  2. stimulation of GPR17 (zeige GPR17 Proteine) by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (zeige MBP Proteine) expression levels mainly by triggering the Galphai/o signaling pathway.

  3. Necdin (zeige NDN Proteine) is a candidate downstream effector for Galphao.

  4. This heterozygous Gnao1 +/G184S mutation produces early neonatal and adult lethality accompanied by epileptiform discharges.

  5. These results highlight that sensory neurons of the Galphao-expressing vomeronasal subsystem, together with the receptors they express and the molecular cues they detect, control a wide range of fundamental mating and reproductive behaviors in female mice.

  6. Data indicate that rectifying potassium channel (zeige KCNAB2 Proteine) Kir2.4 (zeige KCNJ14 Proteine) interacts with G-protein subunit Galphao.

  7. Data show that Galphao is an essential requirement for the display of male-male territorial aggression as well as maternal aggression.

  8. Data suggest that the novel R234H mutation imparts oncogenic properties to Galphao by accelerating nucleotide exchange and rendering it constitutively active.

  9. The 2.9 A crystal structure of the enigmatic, neuronal G protein Galpha(o) in the GTP (zeige AK3 Proteine) hydrolytic transition state, complexed with RGS16 (zeige RGS16 Proteine).

  10. Go alpha subunit (zeige POLG Proteine) mainly appears to be bound to the cell membrane and concentrated in the thin finger-like dendrites of rod bipolar cells, as well as in green fluorescent protein-positive cone bipolar cells.

Caenorhabditis elegans (C. elegans) Guanine Nucleotide Binding Protein (G Protein), alpha Activating Activity Polypeptide O (GNAO1) Interaktionspartner

  1. Following food deprivation G protein alpha(o) is activated via RIC-8 (zeige RIC8A Proteine) activation.

  2. findings show that the GoLoco-containing proteins GPR-1 and GPR-2, as well as the Galpha subunits GOA-1 and GPA-16, were essential for generation of proper pulling forces in asymmetric spindle positioning

  3. Data show that the asymmetry of GPR-1/2 (which act with GOA-1 and GPA-16) localization depends on PAR-3 and its downstream intermediate LET-99, as well as on the MES (zeige MKS1 Proteine)-1/SRC-1 (zeige NCOA1 Proteine) signaling pathway.

  4. Our results suggest that EGL-47 regulates egg laying by activating Galpha(o) in the hermaphrodite-specific motor neurons to inhibit their activity.

  5. down-regulation of EGL-30-DAG signaling by GOA-1 underlies olfactory adaptation and plasticity of chemotaxis

  6. The stravation response is fully dependent on the subsequent activation of the G alpha(q) ortholog EGL-30.

  7. These results suggest that Galpha signaling and LET-99 control centration by regulating polarized actomyosin contraction.

  8. Serotonin signaling is regulated by modulating serotonin biosynthesis and Galphao and Galphaq (zeige GNAQ Proteine) act in the same neurons to have opposing effects on behavior, in part, by antagonistically regulating transcription of specific genes.

  9. Goa-1 Goalpha and let-60 Ras act in parallel to gpc-1 in olfactory pathways.

GNAO1 Protein Überblick

Protein Überblick

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.

Alternative names and synonyms associated with GNAO1

  • G protein alpha subunit (gna0)
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (GNAO1)
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (Gnao1)
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O (gnao1)
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a (gnao1a)
  • guanine nucleotide binding protein, alpha O (Gnao1)
  • Protein GOA-1 (goa-1)
  • alphaO Protein
  • AW050213 Protein
  • G-ALPHA-o Protein
  • Galphao Protein
  • Gnao Protein
  • gnao1 Protein
  • gnao1-A Protein
  • RATBPGTPC Protein
  • wu:fq26h05 Protein
  • XGalpha01 Protein
  • zgc:73315 Protein

Bezeichner auf Proteinebene für GNAO1

guanine nucleotide-binding protein G(o) subunit alpha , GTP-binding protein alpha o , guanine nucleotide binding protein, alpha O polypeptide 1 , GTP-binding protein G39 , Galpha o1 , GTP-binding protein alpha-o subunit , Go alpha

GENE ID SPEZIES
397896 Xenopus laevis
2775 Homo sapiens
50664 Rattus norvegicus
394423 Xenopus laevis
415698 Gallus gallus
609157 Canis lupus familiaris
281792 Bos taurus
100716648 Cavia porcellus
393760 Danio rerio
14681 Mus musculus
172505 Caenorhabditis elegans
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