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GNAI1 Proteine (GNAI1)

Bezeichnung:
Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 Proteine (GNAI1)
Auf www.antikoerper-online.de finden Sie aktuell 12 Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen GNAI1 Antikörper (67) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 83 GNAI1 Produkte verfügbar.
Synonyme:
AU046200, BPGTPB, Gi, Gialpha1, Gnai-1, gnai1, zgc:63957
alle Proteine anzeigen Gen GeneID UniProt
GNAI1 14677 B2RSH2
GNAI1 2770 P63096
GNAI1 25686 P10824

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Am meisten referenzierte GNAI1 Proteine

  1. Human GNAI1 Protein expressed in Escherichia coli (E. coli) - ABIN667567 : Simon, Strathmann, Gautam: Diversity of G proteins in signal transduction. in Science (New York, N.Y.) 1991 (PubMed)
    Zeige alle 2 Referenzen für ABIN667567

Weitere Proteine zu GNAI1 Interaktionspartnern

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1) Interaktionspartner

  1. stimulation of GPR17 (zeige GPR17 Proteine) by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (zeige MBP Proteine) expression levels mainly by triggering the Galphai/o signaling pathway.

  2. Gnai1 missense mutation is responsible of hyperpigmentation in mouse model.

  3. acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.

  4. Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.

  5. By using mice deficient in individual Galphai/o G-protein subunits, authors demonstrate that Galphai1 and Galphai3 are the critical in vivo targets of ADP-ribosylation underlying vasoactive amine sensitization elicited by pertussis toxin exposure.

  6. leucine can directly facilitate insulin (zeige INS Proteine) signaling through a Galphai protein-dependent intracellular signaling pathway

  7. Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors.

  8. Mice with mutations of Gnai1 or Gnai2 (zeige GNAI2 Proteine) have neither fusions of ribs nor lumbar vertebrae, but loss of both Gnai3 (zeige GNAI3 Proteine) and one of the other two genes increases the number and severity of rib fusions without affecting the lumbar fusions.

  9. Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o (zeige GNAO1 Proteine)) upon activation of mGluR6 (zeige GRM6 Proteine) closes the TRPM1 (zeige TRPM1 Proteine) channel, perhaps via a direct interaction.

  10. RGS14 (zeige RGS16 Proteine) can form complexes with GPCRs in cells that are dependent on Galpha (zeige SUCLG1 Proteine)(i/o) and these RGS14 (zeige RGS16 Proteine).Galpha (zeige SUCLG1 Proteine)(i1).GPCR (zeige GPBAR1 Proteine) complexes may be substrates for other signaling partners such as Ric-8A (zeige RIC8A Proteine)

Human Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1) Interaktionspartner

  1. These findings suggest that Gi1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs.

  2. CGRP (zeige S100A12 Proteine) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (zeige GNAS Proteine), Galphai, and Galphaq (zeige GNAQ Proteine)/11 pathways.

  3. biochemical and computational data indicate that the interactions between alpha5, alpha1, and beta2-beta3 are not only vital for GDP release during G protein activation, but they are also necessary for proper GTP binding (zeige RND2 Proteine) (or GDP rebinding).

  4. Data indicate that hydroxyurea (HU) induces SAR1 protein expression, which in turn activates gamma-globin (zeige HBG1 Proteine) expression, predominantly through the Gialpha/JNK (zeige MAPK8 Proteine)/Jun (zeige JUN Proteine) pathway.

  5. Gi alpha subunit (zeige POLG Proteine) was found to be a key modulator of GABAB-receptors signaling in analgesia.

  6. AC5, by binding active Galphai1, interferes with G-protein deactivation and reassembly and thereby might sensitize its own regulation.

  7. Data indicate that focal adhesion kinase (FAK) activation and cell migration require Src, Gi/Go, COX-2 and LOXs activities.

  8. resistin (zeige RETN Proteine) contributes to the pro-inflammatory state of SMC (zeige DYM Proteine) by the up-regulation of CX3CL1 (zeige CX3CL1 Proteine) and CX3CR1 (zeige CX3CR1 Proteine) expression via a mechanism involving NF-kB, AP-1 (zeige FOSB Proteine), and STAT1 (zeige STAT1 Proteine)/3 transcription factors, (2) resistin (zeige RETN Proteine) employs TLR4 (zeige TLR4 Proteine) and Gi-protein signaling.

  9. leucine can directly facilitate insulin (zeige INS Proteine) signaling through a Galphai protein-dependent intracellular signaling pathway

  10. Data suggest that chemokine (zeige CCL1 Proteine) binding to CCX-CKR (zeige CCRL1 Proteine) (a) recruits Gi proteins and beta-arrestin (beta-arr (zeige SAG Proteine)) with high affinity.

GNAI1 Protein Überblick

Protein Überblick

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GNAI1

  • guanine nucleotide binding protein (G protein), alpha inhibiting 1 (Gnai1)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (gnai1-b)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (GNAI1)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (Gnai1)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (gnai1)
  • AU046200 Protein
  • BPGTPB Protein
  • Gi Protein
  • Gialpha1 Protein
  • Gnai-1 Protein
  • gnai1 Protein
  • zgc:63957 Protein

Bezeichner auf Proteinebene für GNAI1

adenylate cyclase-inhibiting G alpha protein , guanine nucleotide binding protein, alpha inhibiting 1 , guanine nucleotide-binding protein G(i) subunit alpha-1 , Gi1 protein alpha-subunit , alpha-subunit of G-protein, type G-alpha-i-1 , guanine nucleotide-binding protein G(i), alpha-1 subunit , Gi1 protein alpha subunit , Gi-alpha-1 protein , guanine nucleotide binding protein (G protein), alpha inhibiting 1 , Galpha i1a

GENE ID SPEZIES
14677 Mus musculus
100135528 Cavia porcellus
399463 Xenopus laevis
396368 Gallus gallus
2770 Homo sapiens
397505 Sus scrofa
281790 Bos taurus
25686 Rattus norvegicus
393946 Danio rerio
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