UCHL1 Proteine (UCHL1)

Auf www.antikoerper-online.de finden Sie aktuell 41 Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) Proteine von 17 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen UCHL1 Antikörper (623) und UCHL1 Kits (26) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 706 UCHL1 Produkte verfügbar.
Synonyme:
AW822034, C88048, cb358, gad, MGC132191, PARK5, PGP9.5, PGP 9.5, PGP95, R75593, Uch-L1, UCHL-1, uchl1, wu:fc55h08
alle Proteine anzeigen Gen GeneID UniProt
UCHL1 22223 Q9R0P9
UCHL1 7345 P09936
UCHL1 29545 Q00981

UCHL1 Proteine (UCHL1) nach Spezies

Weitere Proteine zu UCHL1 Interaktionspartnern

Mouse (Murine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) Interaktionspartner

  1. The UCHL1 may play a role in myogenesis by promoting myoblast proliferation and inhibiting differentiation.

  2. our study provides novel insights into the mechanisms of UCH-L1-mediated neurobiological functions and suggests that ubiquitination is an important regulatory signal for TrkB (zeige NTRK2 Proteine)

  3. Effects of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) inhibition on sperm incorporation and cortical tension in mouse eggs.

  4. The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene (zeige RAB1A Proteine)-induced transformation of, germinal center B cells.

  5. Pharmacological inhibition of UCHL1 exacerbates rather than ameliorates disease symptoms in a mouse model of SMA (zeige SMN1 Proteine). Thus, pharmacological inhibition of UCHL1 is not a viable therapeutic target for SMA (zeige SMN1 Proteine).

  6. Parkin (zeige PARK2 Proteine) mediates K63-linked polyubiquitination of UCH-L1 in cooperation with the Ubc13 (zeige UBE2N Proteine)/Uev1a E2 ubiquitin-conjugating enzyme (zeige UBE2L6 Proteine) complex and promotes UCH-L1 degradation by the autophagy-lysosome pathway.

  7. defective UCHL1 function may be an early contributor to vulnerability of pancreatic beta-cells for protein misfolding and proteotoxicity, hallmark defects in islets of T2DM

  8. UCH-L1 facilitates PDGF (zeige PDGFA Proteine)-BB-induced suppression of autophagic degradation of p21WAF1/Cip1 proteins in cardiac fibroblasts

  9. UCHL1 upregulation in ACTN4 (zeige ACTN4 Proteine)-associated FSGS (zeige ACTN4 Proteine).

  10. downregulated miR (zeige MLXIP Proteine)-181b induces neuroprotection against ischemic injury through negatively regulating HSPA5 (zeige HSPA5 Proteine) and UCHL1 protein levels

Human Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) Interaktionspartner

  1. Aberrant expression of UCHL1 in pediatric high-grade gliomas may promote cell invasion, transformation, and self-renewal properties, at least in part, by modulating Wnt (zeige WNT2 Proteine)/Beta catenin (zeige CTNNB1 Proteine) activity

  2. Suppression of MITF (zeige MITF Proteine) activity by UCHL1 via protein degradation might aid in the development of new therapeutic approaches for melanoma or dyspigmentation disorders.

  3. Overexpression of UCH-L1 in MCF7 cells up-regulated MDR1, CD147 (zeige BSG Proteine), MMP2 (zeige MMP2 Proteine), and MMP9 (zeige MMP9 Proteine), which conferred multidrug resistance and promoted migration/invasion.

  4. This study demonstrated that UCH-L1 was detectible within 1 hour of injury and rose rapidly and peaked at 8 hours after injury and declined rapidly over 48 hours.

  5. This study establishes the importance of UCHL1 in neurodegeneration, provides new mechanistic insight about ubiquitin processing, and underlines the complexity of the different roles of UCHL1

  6. TGF-beta1 (zeige TGFB1 Proteine) can promote PGP9.5 expression in Cancer associated fibroblasts to facilitate the growth of cancer cells.

  7. PGP9.5 is also expressed in benign fibroblastic lesions

  8. cytoplasmic accumulation of P53 (zeige TP53 Proteine) was strongly associated with the unmethylated UCHL1 profile (P = 0.006), supporting the relationship between these two proteins in sporadic colorectal cancer

  9. UCHL1 has a role in Alzheimer Disease [review]

  10. UCHL1 expression is highly upregulated upon hepatic stellate cell (HSC (zeige FUT1 Proteine)) activation and is involved in the regulation of HSC (zeige FUT1 Proteine) proliferation

Cow (Bovine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) Interaktionspartner

  1. These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of cortical granules.

Pig (Porcine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) Interaktionspartner

  1. The elevation in UCH-L1 concentration is consistent with the severity of neural apoptosis following DHCA.

  2. Data report that ubiquitin carboxy-terminal hydrolase 1 is expressed in spermatogonia located at the basement membrane of seminiferous tubules at high and low levels, but not in differentiated germ cells distant from the BM.

Horse (Equine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) Interaktionspartner

  1. There was no difference in enteric neuronal density and distribution in the groups of animals with intestinal disease compared with those without, apart from two (out of 28) horses with intestinal disease that showed reduction in PGP 9.5 immunoreactivity.

UCHL1 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.

Alternative names and synonyms associated with UCHL1

  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (uchl1)
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1)
  • Ubiquitin carboxyl-terminal hydrolase isozyme L1 (uchl1)
  • ubiquitin carboxyl-terminal esterase L1 (LOC100304750)
  • ubiquitin carboxyl-terminal esterase L1 (LOC100348287)
  • ubiquitin carboxyl-terminal esterase L1 (LOC100357806)
  • ubiquitin carboxy-terminal hydrolase L1 (Uchl1)
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (Uchl1)
  • AW822034 Protein
  • C88048 Protein
  • cb358 Protein
  • gad Protein
  • MGC132191 Protein
  • PARK5 Protein
  • PGP9.5 Protein
  • PGP 9.5 Protein
  • PGP95 Protein
  • R75593 Protein
  • Uch-L1 Protein
  • UCHL-1 Protein
  • uchl1 Protein
  • wu:fc55h08 Protein

Bezeichner auf Proteinebene für UCHL1

ubiquitin carboxyl-terminal hydrolase isozyme L1 , ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) , ubiquitin carboxyl-terminal esterase L1 , gracile axonal dystrophy , neuron cytoplasmic protein 9.5 , protein gene product 9.5 , ubiquitin thioesterase L1 , ubiquitin C-terminal hydrolase , PGP 9.5 , PGP9.5 , UCH-L1 , ubiquitin carboxy-terminal hydrolase L1 , ubiquitin C-terminal hydrolase-L1 , ubiquitin carboxyl-terminal hydrolase L1 , ubiquitin thiolesterase L1

GENE ID SPEZIES
325119 Danio rerio
461185 Pan troglodytes
479098 Canis lupus familiaris
751589 Taeniopygia guttata
770302 Gallus gallus
496780 Xenopus (Silurana) tropicalis
735204 Xenopus laevis
100196868 Salmo salar
100304750 Ictalurus punctatus
100348287 Oryctolagus cuniculus
100357806 Oryctolagus cuniculus
22223 Mus musculus
7345 Homo sapiens
29545 Rattus norvegicus
514394 Bos taurus
100714582 Cavia porcellus
396637 Sus scrofa
100033838 Equus caballus
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