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Micrarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2/ (zeige MEOX2 ELISA Kits)Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium.
The data demonstrate that PARAXIS initiates and stabilizes somite epithelialization by integrating signals from multiple pathways to control the reorganization of the ECM (zeige MMRN1 ELISA Kits), cytoskeleton, and adhesion junctions during MET.
Tcf15 contributes toward steering pluripotent cells in the direction of somatic lineages and that it will serve as a valuable tool for monitoring and interrogating early developmental transitions.
The molecular characterization of paraxis is reported inh the paraxialmesoderm and somites.
analysis of developmental expression of Xenopus paraxis
Genetic variation in MEOX2 (zeige MEOX2 ELISA Kits), but not TCF15, is a strong predictor of CHD (zeige CHDH ELISA Kits). Further experimental studies should elucidate the underlying molecular mechanisms.
Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2 (zeige MEOX2 ELISA Kits)/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium.
Activation of TGFbeta (zeige TGFB1 ELISA Kits) recruits p300 (zeige EP300 ELISA Kits) to the KLF5 (zeige KLF5 ELISA Kits)-Smad (zeige SMAD1 ELISA Kits) complex to acetylate KLF5 (zeige KLF5 ELISA Kits), and the complex with acetylated KLF5 (zeige KLF5 ELISA Kits) binds to the Smad (zeige SMAD1 ELISA Kits) binding element and alters the binding of other factors to p15 (zeige CDKN2B ELISA Kits) promoter to induce its transcription
The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding.
, bHLH transcription factor scleraxis
, basic helix-loop-helix transcription factor scleraxis
, protein bHLH-EC2
, paraxis-like protein
, bHLH-EC2 protein
, transcription factor 15
, basic helix-loop-helix transcription factor 15
, class A basic helix-loop-helix protein 40
, Protein bHLH-EC2
, basic helix-loop-helix transcription factor