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anti-Human CNR1 Antikörper:
anti-Mouse (Murine) CNR1 Antikörper:
anti-Rat (Rattus) CNR1 Antikörper:
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Human Polyclonal CNR1 Primary Antibody für WB - ABIN1881140
Van Laere, Casteels, Dhollander, Goffin, Grachev, Bormans, Vandenberghe: Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivo. in Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010
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Human Polyclonal CNR1 Primary Antibody für ELISA, WB - ABIN250833
Porcella, Maxia, Gessa, Pani: The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. in The European journal of neuroscience 2000
Show all 3 Pubmed References
Human Polyclonal CNR1 Primary Antibody für ICC, IHC (fro) - ABIN152711
Mulhern, Madson, Danford, Ikesugi, Kador, Shinohara: The unfolded protein response in lens epithelial cells from galactosemic rat lenses. in Investigative ophthalmology & visual science 2006
phenotypes associated with rare CNR1 variants are reminiscent of those implicated in the theory of clinical endocannabinoid deficiency syndrome. The severe phenotypes associated with rare DAGLA (zeige DAGLA Antikörper) variants underscore the critical role of rapid 2-AG synthesis and the endocannabinoid system in regulating neurological function and development
two agonist-bound crystal structures of human CB1 in complex with a tetrahydrocannabinol (AM11542) and a hexahydrocannabinol (AM841) at 2.80 A and 2.95 A resolution, respectively
that a genetically modulated balancing of signaling within the CB1-COX-2 (zeige COX2 Antikörper) pathway may reflect on more or less efficient patterns of prefrontal activity during working memory
In cotransfected HEK (zeige EPHA3 Antikörper)-293 cells, SSTR5 (zeige SSTR5 Antikörper) and CB1R existed in a constitutive heteromeric complex under basal condition, which was disrupted upon agonist treatments. Furthermore, concurrent receptor activation led to preferential formation of SSTR5 (zeige SSTR5 Antikörper) homodimer and dissociation of CB1R homodimer.
CB1R availability was inversely associated with BMI in homeostatic brain regions such as the hypothalamus and brainstem areas in both patients with food intake disorders(FID) and healthy subjects. However, in FID patients, CB1R availability was also negatively correlated with BMI throughout the mesolimbic reward system.
hepatic expression of CB1 and CB2 (zeige CNR2 Antikörper) plays an important role during the progression of fibrosis induced by chronic hepatitis B
propose here a possible unifying theory of CB1 receptor functions.
Patients with schizophrenia showed increased CB1A expression in cells of the innate immune system and simpler correlation network between cytokines and CBRs expression when compared with controls.
our systematic review on potential associations of CNR1 polymorphisms with schizophrenia and its subphenotypes revealed conflicting data, with results tending towards a negative association.
Our study disclosed an increased risk of CVS among individuals with AG and GG genotypes of CNR1 rs806380 ( P <0.01), whereas the CC genotype of CNR1 rs806368 was associated with a decreased risk of CVS ( P <0.05). In addition CT and CC genotypes of CNR1 rs806368 were associated with a family history of migraines.
renal proximal tubule cell CB1R contributes to the pathogenesis of obesity-induced renal lipotoxicity and nephropathy by regulating the liver kinase B1 (zeige STK11 Antikörper)/AMP-activated protein kinase (zeige PRKAA2 Antikörper) signaling pathway
a protein involved in macroautophagy/autophagy (a conserved lysosomal degradation pathway), BECN2 (beclin 2), mediates cannabinoid tolerance by preventing CNR1 recycling and resensitization after prolonged agonist exposure, and deletion of Becn2 rescues CNR1 activity in mouse brain and conveys resistance to analgesic tolerance to chronic cannabinoids
N-arachidonoyl ethanolamine and 2-arachidonoyl glycerol hydrolyzing enzymes, FAAH (zeige FAAH Antikörper) and MAGL (zeige MGLL Antikörper), and the CB1 receptor link the endocannabinoid system to broader lipid signaling networks in contrasting ways, potentially altering neurotransmission and behavior independently of cannabinoid receptor signaling.
Given overlapping and complementary functions of CB1 and CB2 (zeige CNR2 Antikörper) receptors, we queried whether double-knockout mice would show an exacerbated neurological phenotype
this study shows that the expression of CB1 receptor in B-lymphocytes is differentially regulated during pregnancy
Loss of adipocyte CB1 affects energy balance by promoting a profound remodeling in depot-specific adipocyte functions.
mGluR5 (zeige GRM5 Antikörper) and CB1 act in concert to activate neuroprotective cell signaling pathways and promote neuronal survival.
Salicylate-induced tinnitus may be associated with increased mRNA expression of the DR1A gene - but with decreased mRNA expression of the CR1 (zeige TDGF1 Antikörper) gene - in the cochlea and in many tinnitus-related brain areas.
analysis of the composition and differences of CB1 protein complexes in glutamatergic neurons and in GABAergic interneurons in hippocampal mouse tissue by proteomics
Identification of mouse CB1 receptor splice variants may help to explain differences found between human and mouse endocannabinoid systems and improve the understanding of CB1 receptor signaling and trafficking in different species
genetic or chemical inhibition of cannabinoid receptor (Cnr (zeige PCDHA1 Antikörper)) activity disrupts liver development and metabolic function in zebrafish.
CB1 function is required in the early embryo for axonal growth and fasciculation.
The endocannabinoid system in renal cells: regulation of sodium transport by CB1 receptors through distinct cell signaling pathways
Anandamide, through CB1 and TRPV1 (zeige TRPV1 Antikörper) activation, is involved in sperm release from the oviductal reservoir.
A novel mechanism has been identified underlying a CB1R-mediated increase in retinal ganglion cell intrinsic excitability acting through AMPK (zeige PRKAA2 Antikörper)-dependent inhibition of NKCC1 (zeige SLC12A2 Antikörper) activity.
CB1 functionality increased with development at both central and peripheral level.
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
cannabinoid receptor 1
, central cannabinoid receptor
, brain-type cannabinoid receptor
, striatal cannabinoid receptor type 1 protein
, CB1 cannabinoid receptor
, cannabinoid receptor CB-1
, cannabinoid receptor 1 (brain)
, cannabinoid receptor 1-like
, cannabinoid 1 receptor
, cannabinoid receptor 1/CB1