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Suggest that CTMP may therefore play a critical role in mitochondrial-mediated apoptosis in lung cancer cells.
Data show low or moderate methylation was found in seven selected genes BAD, BBC3 (zeige BBC3 Proteine), CAV1 (zeige CAV1 Proteine), CDK2AP1 (zeige CDK2AP1 Proteine), NPM1 (zeige NPM1 Proteine), PRKCDBP (zeige PRKCDBP Proteine) and THEM4.
CTMP induces translocation of Akt (zeige AKT1 Proteine) to the membrane and thereby increases the level of Akt (zeige AKT1 Proteine) phosphorylation. As a result, CTMP enhances various cellular activities that are principally mediated by the PI3-kinase (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) pathway.
Proper maturation of CTMP is essential for its pro-apoptotic function. CTMP delays PKB (zeige AKT1 Proteine) phosphorylation following cell death induction, suggesting that CTMP regulates apoptosis via inhibition of PKB (zeige AKT1 Proteine).
Phosphorylation on Ser37/Ser38 of CTMP is important for the prevention of mitochondrial localization of CTMP, eventually leading to cell death by binding to heat shock protein 70 (zeige HSP70 Proteine).
Results suggest that Akt (zeige AKT1 Proteine) is phosphorylated and translocated to nucleus after traumatic brain injury (TBI (zeige TBPL1 Proteine)) to exert neuroprotective effects; however, CTMP is simultaneously triggered to inhibit the phosphorylation of Akt (zeige AKT1 Proteine)
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas.
thioesterase superfamily member 4
, acyl-coenzyme A thioesterase THEM4
, C-terminal modulator protein
, acyl-CoA thioesterase THEM4
, carboxyl-terminal modulator protein