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Human FRS2 Protein expressed in Wheat germ - ABIN1354441
Krejci, Masri, Salazar, Farrington-Rock, Prats, Thompson, Wilcox: Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins. in The Journal of biological chemistry 2007
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They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies.
Results identify FRS2 as an oncogene (zeige RAB1A Proteine) in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications.
Increased expression of FRS2alpha (and FGFR1 (zeige FGFR1 Proteine)) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma (zeige MOK Proteine) treated with sorafenib.
The signaling complex appears to integrate the input from FGFR (zeige FGFR2 Proteine) and EphA4 (zeige EPHA4 Proteine), and release the output signal through FRS2alpha.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development.
The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling.
Patient with pigmentation disorders and vitiligo (zeige MITF Proteine) show decreased expression of mRNA.
Data indicate that the FGFR (zeige FGFR2 Proteine)/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas.
a novel signaling network containing FRS2, CAP and flotillin-1 (zeige FLOT1 Proteine)
Validated FRS2 amplification in both Well-differentiated liposarcoma and dedifferentiated liposarcoma.
Fgfr (zeige FGFR2 Proteine) signaling in nephron progenitors appears to be mediated predominantly by Frs2alpha.
Analysis of a mutant Fgfr1 (zeige FGFR1 Proteine) allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 (zeige SOX2 Proteine) maintenance can be regulated by MAP kinase (zeige MAPK1 Proteine).
data from two models showed that FRS2 played different roles in the regulation of two activity levels of the ERK (zeige EPHB2 Proteine) pathway components in the epididymis.
Genetic evidence further supports that the formation of an Frs2alpha-Shp2 (zeige PTPN11 Proteine) complex and its recruitment to FGF receptors are crucial for downstream ERK (zeige EPHB2 Proteine) signaling in this process.
Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development.
FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.
The FGF signaling axis activates mTOR (zeige FRAP1 Proteine) via the FGF receptor (zeige FGFR2 Proteine) substrate 2alpha (FRS2alpha)-mediated PI3K/Akt (zeige AKT1 Proteine) pathway, and suppresses autophagy activity in MEFs.
although Fgfr2 (zeige FGFR2 Proteine) and Frs2alpha have crucial roles in the ureteric lineage, they appear to act separately and additively.
Msx2 and Runx2 (zeige RUNX2 Proteine) likely function together to induce PC-1 (zeige PCSK1 Proteine) gene expression in osteoblastic cells and FGF signaling stimulates Msx2 transcriptional activity through the Frs2 mediated MAPK (zeige MAPK1 Proteine) signaling pathway
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
fibroblast growth factor receptor substrate 2
, FGFR signalling adaptor
, FGFR substrate 2
, FGFR-signaling adaptor SNT
, suc1-associated neurotrophic factor target 1