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Expression of SYK and its splice variants was significantly lower in tumors with MSI, and in KRAS wild type, BRAF mutant and PTEN mutant tumors
combined use of butyrate and highly specific Syk inhibitor BAY61-3606 does not enhance differentiation and apoptosis of colonocytes. Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk- and ERK1/2 (zeige MAPK1/3 ELISA Kits)-dependent manner.
Study demonstrates that redundant complexes formed by the mutant SYK(Y3F) protein allow it to maintain signaling to receptor-proximal interaction partners, resulting in proper initiation of BCR (zeige BCR ELISA Kits)-proximal signals.
The study identified the criteria for the design of binders that specifically address either the Syk or the Zap-70 (zeige ZAP70 ELISA Kits) Tandem Src (zeige SRC ELISA Kits) Homology 2 Domains, tSH2 (zeige tshz2 ELISA Kits). While Syk tSH2 (zeige tshz2 ELISA Kits) has a rather broad substrate scope, ZAP-70 (zeige ZAP70 ELISA Kits) tSH2 (zeige tshz2 ELISA Kits) required a proximal arrangement of the phosphotyrosine ligands in defined strand orientation.
SYK mediates the actions of EPO (zeige EPO ELISA Kits) and GM-CSF (zeige CSF2 ELISA Kits) and coordinates with TGF-beta (zeige TGFB1 ELISA Kits) in erythropoiesis.
study demonstrates that high SYK expression is a common feature of CD21 (zeige CR2 ELISA Kits)(low) B cells independent of the underlying disorder, and that this high expression is sufficient to drive constitutive phosphorylation of SYK and its immediate targets Bruton's tyrosine kinase (zeige BTK ELISA Kits) and phospholipase Cgamma2
IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta (zeige IL1B ELISA Kits) responses in a TLR2 (zeige TLR2 ELISA Kits)- and FcgammaR-dependent fashion. FcgammaR-mediated Syk activation leads to NLRP3 (zeige NLRP3 ELISA Kits) inflammasome-dependent IL-1beta (zeige IL1B ELISA Kits) production in macrophages.
High SYK expression is associated with lymphangioleiomyomatosis.
NKp65 utilizes a hemi-immunoreceptor tyrosine-based activation motif -like motif for cellular activation that requires Syk, although Syk appears not to be recruited to NKp65.
Syk is a key regulator of Hoxa9 (zeige HOXA9 ELISA Kits)/Meis1 (zeige MEIS1 ELISA Kits)-driven acute myeloid leukemia (zeige BCL11A ELISA Kits).
SYK could induce HO-1 (zeige HMOX1 ELISA Kits) expression by regulating the Akt (zeige AKT1 ELISA Kits) phosphorylation level in H9c2 with A/H injury, protecting H9c2 from the injury induced by A/H treatment.
identified both Syk and Src (zeige SRC ELISA Kits) signaling pathways as ones that participate in Borrelia burgdorferi phagocytosis and the resulting cytokine activation.
These results identify Syk as a critical component of skin inflammation in a mouse model of epidermolysis bullosa acquisita
Syk was identified as the target enzyme most strongly inhibited by water extract of Cordyceps bassiana.
The downmodulation of Syk expression and phosphorylation in intestinal DCs could be important mechanisms through which helminths induce regulatory DCs that limit colitis.
ephrin B3 (zeige EFNB3 ELISA Kits)/EphB2 (zeige EPHB2 ELISA Kits) are obvious candidates for driving the Syk-dependent repulsive response.
The effect of Smad4 (zeige SMAD4 ELISA Kits) was at least partially mediated by the downstream effectors Syk and ROCK2 (zeige ROCK2 ELISA Kits) transcription in megakaryocytes.
Gene expression analysis of lung tissues revealed that HDM (zeige HDAC3 ELISA Kits)-induced expression of IL-17 (zeige IL17A ELISA Kits) and CXCL-1 (zeige CXCL1 ELISA Kits) was significantly attenuated in both Sykdel/del and GSK143-treated mice. CONCLUSION: Syk inhibitors may play a role in the management of neutrophilic asthma
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase