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VTN (zeige VTN ELISA Kits) levels were increased in cell supernatants from vascular smooth muscle cells that overexpress NOR-1
NR4A2 (zeige NR4A2 ELISA Kits) and NR4A3 are components of a downstream transcriptional response to PKA activation in the neutrophil, and that they positively regulate neutrophil survival and homeostasis.
NOR1 suppresses cancer stem-like cell properties in nasopharyngeal carcinoma cells by inhibiting the AKT (zeige AKT1 ELISA Kits)-GSK-3beta (zeige GSK3b ELISA Kits)-Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits)-ALDH1A1 (zeige ALDH1A1 ELISA Kits) signaling circuit.
Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 or NR4A1 (zeige NR4A1 ELISA Kits) revealed that apoptosis was driven similarly by induction of BAK (zeige BAK1 ELISA Kits), Puma (zeige BBC3 ELISA Kits), BIK (zeige BIK ELISA Kits), BIM (zeige BCL2L11 ELISA Kits), BID (zeige BID ELISA Kits), and Trail. Overall, our results showed that NR4A3 possesses robust tumor suppressor functions of similar impact to NR4A1 (zeige NR4A1 ELISA Kits) in aggressive lymphomas
Study found a marked down-regulated gene expression of the NR4A subfamily (NR4A1 (zeige NR4A1 ELISA Kits), NR4A2 (zeige NR4A2 ELISA Kits), and NR4A3) obtained from Parkinson's disease patients, but only a NR4A1 (zeige NR4A1 ELISA Kits) decrease in Alzheimer's disease patients compared to healthy controls. This study reports that the entire NR4A subfamily and not only NR4A2 (zeige NR4A2 ELISA Kits) could be systemically involved in Parkinson's disease.
the role of intragenic DNA hypermethylation in reducing the expression of NR4A3 in AML (zeige RUNX1 ELISA Kits)
Overexpression of NR4A3 in adipocytes produces a complex phenotype characterized by impaired glucose metabolism and low serum catecholamines due to enhanced degradation by adipose tissue.
NOR1 promotes the progression of hepatocellular carcinoma cells by activating Notch (zeige NOTCH1 ELISA Kits) pathway.
using RNA interference, the identified compounds corroborate the role of Tec kinase in unconventional secretion of FGF2 (zeige FGF2 ELISA Kits).
accumulation of NR4A3 is specific to alpha-synucleinopathy.
these data indicate that in mature B cells, Tec and Btk (zeige BTK ELISA Kits) may compete for activation of the Akt (zeige AKT1 ELISA Kits) signaling pathway, whereby the activating capacity of Btk (zeige BTK ELISA Kits) is limited by the presence of Tec kinase.
NR4A3 plays an important role in the regulation of CD103 (zeige ITGAE ELISA Kits)+ mDCs by regulating CCR7 (zeige CCR7 ELISA Kits)-dependent cell migration.
PLSCR1 (zeige PLSCR1 ELISA Kits) aggravates anaphylactic reactions by increasing Fc epsion RI-dependent mast cell degranulation.
Genetic knockdown of PLSCR1 (zeige PLSCR1 ELISA Kits) activity reduces intracellular calcium dysregulation, prevents phosphatidylserine externalization, and enables months-long protection of vector-transduced, transgene-expressing cells from microglial phagocytosis.
Study shows that NOR-1 can transduce survival signals in neuronal cells responsible for hypoxiainduced apoptotic insults through activation of a CREB (zeige CREB1 ELISA Kits)/cIAP2 (zeige BIRC3 ELISA Kits)-dependent mechanism
Promoting Liver X receptor-alpha (zeige NR1H3 ELISA Kits) expression inhibits lipopolysaccharide induced inflammation in Kupffer cells through elevating NOR-1 expression.
Identified Nur77 (zeige NR4A1 ELISA Kits)/Nor1 as novel regulators of thrombomodulin (zeige THBD ELISA Kits) expression and function in vascular endothelial cells.
Nr4a3 factor plays crucial role regulatory T cells, mediating the two defining characteristics of regulatory T cells: stability of cell lineage and immunosuppressive functions.
Tec enhances c-Maf (zeige MAF ELISA Kits)-dependent IL-4 (zeige IL4 ELISA Kits) promoter activity. This effect of Tec is counteracted by Ptpn22 (zeige PTPN22 ELISA Kits), which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf (zeige MAF ELISA Kits) thereby attenuating its transcriptional activity.
Phospholipid scramblase 1 regulates phosphatidylserine exposure in response to oxygen stress, leading to beta2-glycoprotein I and IgM binding and lipid-mediated, inflammatory responses.
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.
nuclear receptor subfamily 4, group A, member 3
, chondrosarcoma, extraskeletal myxoid, fused to EWS
, mitogen-induced nuclear orphan receptor
, neuron-derived orphan receptor 1
, nuclear hormone receptor NOR-1
, nuclear receptor subfamily 4 group A member 3
, translocated in extraskeletal chondrosarcoma
, neural orphan nuclear receptor NOR1
, neural orphan receptor 1
, orphan nuclear receptor TEC
, neuron-derived orphan receptor 1/2
, nuclear hormone receptor NOR-1/NOR-2
, PL scramblase 1
, ca(2+)-dependent phospholipid scramblase 1
, transplantability-associated protein 1
, tyrosine-protein kinase Tec
, cytoplasmic tyrosine kinase, Dscr28C related