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anti-Human NR4A1 Antikörper:
anti-Mouse (Murine) NR4A1 Antikörper:
anti-Rat (Rattus) NR4A1 Antikörper:
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Human Polyclonal NR4A1 Primary Antibody für ChIP, ICC - ABIN252681
Nakai, Kartha, Sakurai, Toback, DeGroot: A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. in Molecular endocrinology (Baltimore, Md.) 1991
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Mouse (Murine) Monoclonal NR4A1 Primary Antibody für WB - ABIN967395
Davis, Hazel, Chen, Blenis, Lau: Functional domains and phosphorylation of the orphan receptor Nur77. in Molecular endocrinology (Baltimore, Md.) 1993
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Human Polyclonal NR4A1 Primary Antibody für ELISA, IHC (p) - ABIN188670
Kiss, Oskolás, Tóth, Bouillet, Tóth, Fülöp, Scholtz, Ledent, Fésüs, Szondy: Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77. in European journal of immunology 2006
Cow (Bovine) Polyclonal NR4A1 Primary Antibody für IHC, WB - ABIN2777511
Lu, Suzuki, Yoshikawa, Murakami, Miki, Moriya, Bassett, Rainey, Hayashi, Sasano: Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders. in The Journal of clinical endocrinology and metabolism 2004
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Cow (Bovine) Polyclonal NR4A1 Primary Antibody für IHC, WB - ABIN2782269
Smith, Luk, Newton, Roberts, Sturm, Muscat: Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells. in The Journal of biological chemistry 2008
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beta1-integrin expression is regulated in pancreatic and colon cancer cells by the pro-oncogenic orphan nuclear receptor 4A1
Inhibition of NR4A1-mediated transcriptional activity was involved in the anticancer effects of fangchinoline; fangchinoline represents a novel class of mechanism-based anticancer agents targeting NR4A1 that is overexpressed in pancreatic cancer.
Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 (zeige NR4A3 Antikörper) or NR4A1 revealed that apoptosis was driven similarly by induction of BAK (zeige BAK1 Antikörper), Puma (zeige BBC3 Antikörper), BIK (zeige BIK Antikörper), BIM (zeige BCL2L11 Antikörper), BID (zeige BID Antikörper), and Trail. Overall, our results showed that NR4A3 (zeige NR4A3 Antikörper) possesses robust tumor suppressor functions of similar impact to NR4A1 in aggressive lymphomas
NR4A1 expression is specific to a quiescent subset of T-cells.
we demonstrate that endogenous Nur77 protein expression can serve as a reporter of T-cell receptor and B-cell receptor specific signaling in human peripheral blood mononuclear cells.
we report overexpression of the nuclear receptor NR4A1 in rhabdomyosarcomas that is sufficient to drive high expression of PAX3 (zeige PAX3 Antikörper)-FOXO1A (zeige FOXO1 Antikörper)
Study found a marked down-regulated gene expression of the NR4A subfamily (NR4A1, NR4A2 (zeige NR4A2 Antikörper), and NR4A3 (zeige NR4A3 Antikörper)) obtained from Parkinson's disease patients, but only a NR4A1 decrease in Alzheimer's disease patients compared to healthy controls. This study reports that the entire NR4A subfamily and not only NR4A2 (zeige NR4A2 Antikörper) could be systemically involved in Parkinson's disease.
Nur77 overexpression prevented pulmonary artery smooth muscle cells from proliferation and migration; Nur77 is an important mediator of hypoxia-induced pulmonary vascular remodeling in pulmonary hypertension
Data show Kruppel-like factor 12 (KLF12 (zeige KLF12 Antikörper)) impairs endometrial decidualization by transcriptionally repressing Nur77 protein, and Nur77 overexpression reverses the poor decidual response of endometrial stromal cells (hESCs) in recurrent implantation failure (RIF) patients.
Nur77 decreases ET-1 (zeige EDN1 Antikörper) expression by suppressing NF-kappaB (zeige NFKB1 Antikörper) and p38 MAPK (zeige MAPK14 Antikörper).
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis.
Celastrol promotes Nur77 migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2 (zeige TRAF2 Antikörper). Ubiquitinated Nur77 then interacts with p62/SQSTM1 (zeige SQSTM1 Antikörper), leading to autophagy of dysfunctional mitochondria and alleviation of inflammation.
New transcript variants encode for NUR77 protein isoforms which are significantly smaller in size due to lack of transactivation domain and a part of DNA binding domain. Western blot analysis using NUR77 specific antibody confirmed the existence of these smaller variants in mouse.
Nur77 deficiency compromises myofiber growth, but not the regenerative capacity of myogenic progenitor cells.
Using Nr4a1 transgenic mice, electrically evoked dopamine release was shown to differ between the striosome and matrix compartments of the corpus striatum in a regionally-distinct manner.
Nur77 was found to be an important modulator in microglia function and attenuated pro-inflammatory mediator production.
this study shows that in NR4A1-/- mice, inflammatory Ly6Chigh monocytes contribute to rapid development of arthritis in a serum transfer-induced arthritis model
Nur77 downregulation triggers pulmonary artery smooth muscle cell proliferation and migration in mice with hypoxic pulmonary hypertension
Our findings may throw light on the function of ApoA4 (zeige APOA4 Antikörper) in inflammatory responses and acute-phase reactions, as well as the development of SERPINA3 (zeige SERPINA3 Antikörper) relative diseases.
This study demonstrated that NGFI-B plays a role in controlling correct cerebellar development.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B