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A novel pancancer mechanism of Lyn-dependent control of epithelial-mesenchymal transition and role of this kinase in tumor progression.
Authors demonstrate that LYN kinase is essential for CLL progression. Lyn deficiency results in a significantly reduced CLL burden in vivo.
Our studies indicate not only a concept of mucus hypersecretion in asthma that involves Lyn kinase but also an important therapeutic candidate for asthma.
LPS (zeige IRF6 Proteine) tolerance interferes with TLR4 (zeige TLR4 Proteine) signaling by inhibiting Lyn and c-Src (zeige SRC Proteine) phosphorylation and their recruitment to TLR4 (zeige TLR4 Proteine), while increasing the phosphatase activity and expression of PP2A (zeige PPP2R4 Proteine), PTPN22 (zeige PTPN22 Proteine), PTP1B (zeige PTPN1 Proteine) and MKP1 (zeige DUSP1 Proteine).
SYK (zeige SYK Proteine), LYN and PTPN6 (zeige PTPN6 Proteine) were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients.
Our data suggests that nuclear Lyn is a potential therapeutic target for clear cell renal cell carcinoma (zeige MOK Proteine) and dasatinib affects cellular functions associated with cancer progression via a Src kinase (zeige CSK Proteine) independent mechanism.
Authors discovered in this study that LYN was a critical gene. It was found to be the key nodule of several significant biological networks.
Inhibition of Lyn activity using dasatinib in mantle cell lymphoma overcomes bortezomib resistance.
positively regulates NF-kappaB (zeige NFKB1 Proteine) transactivation through the phosphorylation of the p110 subunit of PI 3 (zeige PI3 Proteine)-kinase
This study showed an interdependence between ROS (zeige ROS1 Proteine) generation and lipid rafts and Lyn relocation leading the cells to undergo the successive acrosome reaction.
these results reveal a role for Lyn as a specific suppressor of the TLR-MyD88 (zeige MYD88 Proteine)-IRF5 (zeige IRF5 Proteine) pathway and illustrate the importance of fine-tuning IRF5 (zeige IRF5 Proteine) activity for the maintenance of immune homeostasis
These findings reveal that the function and regulation of Lyn during B1 cell B cell receptor signaling is distinct from other B cell subsets.
A mutation in LYN, an inhibitory protein tyrosine kinase (zeige YES1 Proteine) that is implicated in systemic autoimmunity, combines with an Aire (zeige AIRE Proteine) mutation to provoke organ-specific autoimmunity.
the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake.
the Lyn mutation in NOD neutrophils is likely responsible for dysregulation of neutrophil adhesion and directed migration.
Oxidized LDL-bound CD36 (zeige CD36 Proteine) recruits an Na/K-ATPase (zeige ATP1A1 Proteine)-Lyn complex in macrophages that promotes atherosclerosis.
Lyn kinase modulates inhibitory signaling to suppress endotoxin-induced lung inflammation.
A complex functional interplay between FcgammaRIIa, Lyn, and alphaIIbbeta3 in immune complex-induced platelet activation.
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
tyrosine-protein kinase Lyn
, v-yes-1 Yamaguchi sarcoma viral related oncogene protein-like protein
, lyn protein tyrosine kinase
, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
, Tyrosine-protein kinase Lyn
, lck/Yes-related novel protein tyrosine kinase
, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
, lyn protein non-receptor kinase
, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog