anti-Maus ITPR1 Antikörper für Enzyme Immunoassay

Recommended ITPR1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) Antikörper
  • D6Pas2
  • ENSMUSG00000072853
  • Gm10429
  • IP3R1
  • InsP3R
  • Ip3r
  • Itpr-1
  • P400
  • Pcp-1
  • Pcp1
  • opt
  • I145TR
  • InsP3R1
  • INSP3R1
  • IP3R
  • SCA15
  • SCA16
  • SCA29
  • inositol 1,4,5-trisphosphate receptor, type 1
  • inositol 1,4,5-trisphosphate receptor 1
  • ITPR1
  • Itpr1
Epitop
C-Term
8
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
44
42
26
1
Wirt
Kaninchen
37
25
Klonalität
Polyklonal
Konjugat
Dieser ITPR1 Antikörper ist unkonjugiert
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
43
42
29
25
12
4
3
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN372880
$ 500.50
Zzgl. Versandkosten $45.00

General

Antigen Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) Antikörper
Epitop C-Term
(8), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(44), (42), (26), (1)
Wirt Kaninchen
(37), (25)
Klonalität
Polyklonal
Konjugat Dieser ITPR1 Antikörper ist unkonjugiert
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(43), (42), (29), (25), (12), (4), (3), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-ITPR1 Antikörper

Target Details ITPR1 Anwendungsinformationen Handhabung Bilder
Spezifität This antibody detects ITPR1 at C-term.
Kreuzreaktivität (Details) Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.
Reinigung Immunoaffinity Chromatography
Immunogen Synthetic peptide corresponding to C-terminal residues of human ITPR1 (Inositol 1,4,5-triphosphate receptor type 1)
Isotyp IgG

Target Details ITPR1

Produktdetails anti-ITPR1 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung IP3 Receptor 1 / ITPR1 (ITPR1 Antibody Abstract)
Hintergrund Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neurotransmitters. Upon binding to the IP3 receptor (IP3R), IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits, that is structurally reminiscent of members of the voltage-gated ion channel superfamily. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Cytosolic calcium levels appear to be regulated by a feedback loop that starts with calcium activation of protein kinase C (PKC) and calcineurin, a protein phosphatase. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations. Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. IP3R type I (IP3R-I) has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II is found predominantly in the brain. IP3R-III is known to be expressed in pancreatic islets, kidney, and the gastrointestinal tract.Synonyms: 4, 5-trisphosphate receptor, 5-trisphosphate receptor type 1, INSP3R1, IP3R1, Inositol 1, InsP3R1, Type 1 InsP3 receptor, Type 1 inositol 1
Gen-ID 3708
NCBI Accession NP_001093422
UniProt Q14643
Pathways Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma

Anwendungsinformationen

Produktdetails anti-ITPR1 Antikörper Target Details ITPR1 Handhabung Bilder zurück nach oben
Applikationshinweise Immunohistochemistry on paraffin sections: 10 μg/mL. Western blot: 1 μg/mL. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-ITPR1 Antikörper Target Details ITPR1 Anwendungsinformationen Bilder zurück nach oben
Konzentration 0.5 mg/mL
Buffer PBS, 0.01 % Sodium Azide, 50 % Glycerol
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Bilder

Produktdetails anti-ITPR1 Antikörper Target Details ITPR1 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
 image for anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (C-Term) antibody (ABIN372880) anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (C-Term) antibody